Switching from Humira to Remicade

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Doc2007
Regular Member


Date Joined Oct 2007
Total Posts : 294
   Posted 7/29/2009 12:45 PM (GMT -6)   
Has anyone switched from Humira to Remicade and found better results?
Im thinking of asking the Doctor if he is willing to do that. I dont want to waste anymore of my time waiting for the Humira to do the trick it obviously isnt working like it should, and thats okay...How long do you have to wait between your last Humira injection and your first Remicade infusion?

crohnielass
Veteran Member


Date Joined Mar 2009
Total Posts : 1117
   Posted 7/29/2009 1:14 PM (GMT -6)   
Hi i was on remi and got a reaction on 2nd infusion the doc wanted me to go on to Humira but i had to have a 4 week washout period before starting it. it must be the same to switch from hum to remi i would of thought. Good luck hope the remi works for you Bev x

Diagnosed with crohn's at 13 now 42
resection, right hemi 1993 In remmision from 93 till last sept with no meds or docs
2 resections small bowel  and fistula jan 09 and given temp stoma. B12 shots,iron syrup,loperimide, Back on citalopram 40mg (for Anxiety)No maintainance drugs.


Sunaddict
Regular Member


Date Joined Jun 2009
Total Posts : 354
   Posted 7/29/2009 1:54 PM (GMT -6)   

How long have you been on humira for? I am the other way around, started with Remicade did for 1 year 4 months. I lost the effectness, and it caused remicade induced RA. I went crippled. Because remicade hows mouse dna, where as humira is fully human. it could take up to 3 months to 1 year to feel full effectness of the humira. Are you sure you don't want to wait it out a little longer? as there aren't allot of different anti-TFN blockers so you really have to feel this isn't working and your willing to go on your last chance. there is I think only 3, humira,remicade,cizmiza(I think I spelled it correctly)

I wish you the best of luck, keep us posted!


25 year old woman. Crohn's all my life but diagnosed at age 18.Been on prednisone 8 times. which they will not give me anymore(doesn't work for me)I am on Prevacide for the ulcers I get in the stomach,pantesa. I've been on and off imuran,entocort,number of others I can think of. I have cronh's in the small bowel,colon,stomach. Since Nov 08 I've been suffering from RA which is just as bad as CD. haven't been able to work for the last 2 years. Awaiting to start Humira since being on Remicade for 1 year 4 months that no longer works.Now on Humira and back on Imuran as well.RA pains all gone!


Doc2007
Regular Member


Date Joined Oct 2007
Total Posts : 294
   Posted 7/29/2009 1:58 PM (GMT -6)   
I've been on it since April

Sunaddict
Regular Member


Date Joined Jun 2009
Total Posts : 354
   Posted 7/29/2009 2:23 PM (GMT -6)   
I would suggest waiting a little longer. But you know how you feel the best. do a little more research on remicade, and see if it's something your interested in. If you are I'd suggest talking to you doctor about taking another med with remicade, like mtx (I wouldn't suggest) or imuran, to avoid whats called antibodies you can get from remicade (that you can't get with humira)
But again like the nurse of humira and my GI said I need to have lost of patience with humira, it wont work right away it'll take a mim of 3 months up to a year. most people on humira on this form, works for them. I'm hoping for the both of us it'll work and fast.
Good luck! xoxo
keep us posted when you've finaly made a decision.
25 year old woman. Crohn's all my life but diagnosed at age 18.Been on prednisone 8 times. which they will not give me anymore(doesn't work for me)I am on Prevacide for the ulcers I get in the stomach,pantesa. I've been on and off imuran,entocort,number of others I can think of. I have cronh's in the small bowel,colon,stomach. Since Nov 08 I've been suffering from RA which is just as bad as CD. haven't been able to work for the last 2 years. Awaiting to start Humira since being on Remicade for 1 year 4 months that no longer works.Now on Humira and back on Imuran as well.RA pains all gone!


xraygrrl
Regular Member


Date Joined Aug 2004
Total Posts : 102
   Posted 7/29/2009 2:28 PM (GMT -6)   
I was on Humira for a year & started to get lupus symptoms. I switched to Remicaid in January after a 2 month period of not taking either. My gut got really bad during those 2 months but the rest of me felt soooo much better! Sadly, I think it's starting to happen with the Remicaid now. I've started trying to work out again as I've gained over 30 pounds since starting Humira & my joints are not happy. I walked on the treadmill for 20 minutes the other day & spent the rest of that evening barely able to walk at all because my feet hurt so bad. It's all so frustrating. I'm thinking about just going with the old medications I used before all of these fancy biologicals came along. I didn't feel as good but at least I could get by & didn't have to work out. :)

Sunaddict
Regular Member


Date Joined Jun 2009
Total Posts : 354
   Posted 7/29/2009 2:34 PM (GMT -6)   

omg!

I didn't hear of anyone have humira induced side effects like remicade. you are the first I hear of. I am so sorry to hear that. I am taking Imuran with Humira.Do you take any other med like imuran to avoid antibodies? in a week of this all my RA pains and criplness has gone I can walk again, and live a normal life (RA wise) my crohn's is off the wall, was in the hospital sunday and Monday (my bday) because of the CD so I am still awaiting for humira to start working for my CD.

I was just talking to my fiance and parents about thinking of stoping all these new meds (remicade, humira) and go back to my normal meds like before. But I was in the hospital weekly before remicade. But atleast I wouldn't have to worry about remi/humira induced ra and lumpus. I agree with you. But scarry at the same time, I have high hopes humira will work with only a little doubt 

I wish all of us the best of luck with these meds.


25 year old woman. Crohn's all my life but diagnosed at age 18.Been on prednisone 8 times. which they will not give me anymore(doesn't work for me)I am on Prevacide for the ulcers I get in the stomach,pantesa. I've been on and off imuran,entocort,number of others I can think of. I have cronh's in the small bowel,colon,stomach. Since Nov 08 I've been suffering from RA which is just as bad as CD. haven't been able to work for the last 2 years. Awaiting to start Humira since being on Remicade for 1 year 4 months that no longer works.Now on Humira and back on Imuran as well.RA pains all gone!


ivy6
Elite Member


Date Joined Sep 2005
Total Posts : 10404
   Posted 7/29/2009 5:15 PM (GMT -6)   
There's a discussion on this in the medications thread, which you can find in my sig.
Co-Moderator Crohn's Forum.

Medications for Crohn's ~~ Diet and Nutritional Therapy for Crohn's


Doc2007
Regular Member


Date Joined Oct 2007
Total Posts : 294
   Posted 7/29/2009 6:33 PM (GMT -6)   
I was not aware that it might take a year to feel the effects, I thought it would be by three months we would know. I will discuss this with my dr on Friday as well.

yankeespg23
Regular Member


Date Joined Dec 2007
Total Posts : 63
   Posted 7/30/2009 10:03 AM (GMT -6)   
Hello
I'm in the same situation now. I have been on humira for almost 2 years, (this oct would have been 2 yr). It started to lose effectiveness for me. It took 6 months for it to work .
I never have been on Remicade, went to humira first.
So, next thurs Aug 6th will be my 1st Remicade infusion. I'm anemic again and start up on iron IV tomorrow.
I would say give humira up to 1 year to work before you give up. I was on weekly humira which was much better than bi-weekly. You can ask your DR. to try weekly 1st then if that fails go to Remicade.
I have been off Humira for 2 months.
My DR also just added Entocort.
Good luck
33 yr old Male from NYC, DX with Crohn's in oct of 1987, at age 12.
Resection in 1990 at age of 15.
Currently on Humira pen shots, 40mg weekly. Cipro 2x a day.
Multi vitamin daily
Anemic again, started iron IV infusions.


rovin1959
Regular Member


Date Joined May 2009
Total Posts : 159
   Posted 7/30/2009 10:59 AM (GMT -6)   
Please keep the  info comming. Humira is out of pocket. Going to remicaid when feeling stronger. Home right now. I allowed an abscess to go too long. Temp.101.2 with aleve. Cipro and flagyl on board. Round and round we go.... Please pay attention to all these smart folks when it comes to almost anything. Do NOT do as I did. nono

Mary Lynn


Sarah_B
Regular Member


Date Joined Feb 2009
Total Posts : 82
   Posted 8/17/2009 9:49 AM (GMT -6)   
Hey Doc,

I was considering asking you about your Humira experience (since your posts seem to depict almost exactly what I'm going through) when I came across this post. Humira seems to be losing it's effectiveness with me as well. I've also been on it since April. I will be seeing my doctor in a couple of weeks to talk to him about it. Since April, I have gotten steadily worse (though it's still bearable). My pain and bowel movements have increased and I am not digesting food very fully anymore (something I have not had problems with until now). I am going to talk to my doctor about switching to weekly injections and when he thinks I should start considering Remicade.

I was wondering if you had spoken to your doctor about the decreased effectiveness yet and what they suggested.
22 years old, Female.
Diagnosed with Crohn's Ileocolitis November 2008.
Currently taking Humira.


Doc2007
Regular Member


Date Joined Oct 2007
Total Posts : 294
   Posted 8/17/2009 12:05 PM (GMT -6)   
Hey Sarah,
 
Whe I saw my doctor and told him about my symptoms...he ran a battery of test that all came back negative...no infection or anything...so with the loose stool and diharea that was getting worse he recomended Metamucil...IT was the best thing any GI has ever done for me! I  have been on Metamucil 3 times a day for three weeks and I feel like a MILLION BUCKS! my stools and BMs became normal...I go aprox 2 to c times a day and I feel fine...cramps subsided to almost nothing...I am picking up weight again and I can eat without pain and running to the rest room. I dont know exactly how it is helping but it in conjuntion with the Humira has been a winning combination. I havent felt this good in years...Since starting Metamucil I dont have diharea, or wet farts, No mucus, no cramping...My appetite is amazing as well...

Sarah_B
Regular Member


Date Joined Feb 2009
Total Posts : 82
   Posted 8/17/2009 12:54 PM (GMT -6)   
That sounds great, except for the weight gain lol (I'm still trying to drop my prednisone weight). I will give it a shot and bring it up with my GI when I see him.

Thanks for the help; glad you're feeling better!
22 years old, Female.
Diagnosed with Crohn's Ileocolitis November 2008.
Currently taking Humira.


metoo50
Regular Member


Date Joined Aug 2007
Total Posts : 46
   Posted 8/26/2009 3:07 PM (GMT -6)   
I also was on Humira from Oct. 2007-June 09. , and found out that after a while it does not work !!! the last shot gave me fever, and I had night sweats during the time of the therapy. I called the support number for Humira, and discuss my case with a professional. I was told that 5% of the people taking Humira have the side effects that I was having. She advised to discuss the late side effect with my GI, I am now off Humira, and taking Entocort. Waiting for the thyroid biopsy result, to see if I can go on Remicade. 

mirowpl
Regular Member


Date Joined Nov 2009
Total Posts : 318
   Posted 11/12/2009 9:59 PM (GMT -6)   
i was on cimzia first. then after 14 months had a blockage. spend 6 days inhospital. now on Pred, Flayg,. Dr wants me to go to remicade. says 50/50 chance it will help so take the chance. i am not so sure. meetng with surgeon next week to understand all surgery options. BTW, had crohn's for 15 yrs, only symptom has been bad anemia. Took asaco, pentasa, iron pills ect. about 18mths ago, latest colocoscopy showed marked deteriatio Dr said i would need surgery in the next 3 to 5 years and to try the newest thing. Well it did not work. I really am concered about remicade and it side effects

j_web
Regular Member


Date Joined Nov 2009
Total Posts : 204
   Posted 11/13/2009 12:05 AM (GMT -6)   
I did about 8 weeks on Humira before switching to Remicade, starting week 10.  Unfortunately had a nasty allergic reaction to my second Remicade infusion and couldn't do any more after that.
 
Now I wish I had waited the full 12 weeks to see if the Humira kicked in.  I will probably have to go back on it one day.


CD since July 2007
DM T1 since January 2008


tamsprote96
Regular Member


Date Joined Apr 2009
Total Posts : 55
   Posted 11/13/2009 3:29 PM (GMT -6)   
I've been on Humira for six months and developed a fistula while on the Humira. Dr is starting my Remicade next week. I am hoping it does the trick since this fistula now has me on Prednisone, Flagyl and Cipro as well as my Pentasa, multi vit, b complex and probiotic. All the pills!
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