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Veteran Member

Date Joined Oct 2007
Total Posts : 1184
   Posted 8/6/2009 3:01 PM (GMT -6)   
Should Mesalazine be taken with food or on an empty stomach? I take it after food so it doesn't irritate my stomach - I use Pentasa.

Diagnosis Oct 07: Mild Crohn's Colitis. Also suffer from bleeding Peptic Ulcers. By the grace of God currently in remission. Current Medication: 1000mg Pentasa Tablets x 2 a day. VSL#3. Asacol Suppository at night.

New Member

Date Joined Aug 2009
Total Posts : 4
   Posted 8/6/2009 3:20 PM (GMT -6)   
check with your pharamcist for quick answer on your med, they've been helpful to me over the years - i'm a crohn's patient/37 years - also take pentasa, same dosage as you, been in remission for a few months - good luck. Does the asacal help with diarrhea?

Veteran Member

Date Joined Feb 2009
Total Posts : 529
   Posted 8/6/2009 3:26 PM (GMT -6)   
From what I remember, it didn't matter either way. I wasn't on it for long, but I think I remember asking the pharmacist and she told me that it didn't matter when I took it.

Veteran Member

Date Joined Apr 2008
Total Posts : 1753
   Posted 8/6/2009 3:34 PM (GMT -6)   
I don't really notice a difference either. I take my first dose at 8:30, and I rarely eat breakfast. There hasn't been an upset stomach yet. Well, from that anyway. Everything else really is a whole other story isn't it?
20 years old, Diagnosed with moderate to severe Crohn's and Colitis in May of 2008.
Currently taking: Prednisone 10 mg, pentasa 2 pills 4x a day, bentyl as needed, omeprazole in the morning, prenatal multivitamin, humira every other week, and Align probiotics prescribed by my GI.
Diet almost completely without refined sugars, wheat, flour, gluten, high lactose dairy, and/or junk food in general.
Learning how to live again.
"He who has a why to live for can bear with almost any how."

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 8/6/2009 3:48 PM (GMT -6)   
I take mine first thing in the morning and last thing at night (Asacol) and I don't have any problems taking it on an empty stomach. I guess whatever works best for you.
Gail*Nanners* Co-Moderator for Crohns Disease and Anxiety/Panic Forum
Been living with Crohn's Disease for 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium  w/Vit D, and Xanax as needed for my anxiety.  Resections in 2002 and 2005. Also diagnosed with Fibromyalgia, Osteoarthritis, and Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Veteran Member

Date Joined Nov 2007
Total Posts : 4055
   Posted 8/6/2009 3:52 PM (GMT -6)   
I don't have any problems either before or after eating...I don't think it matters...just find a method to remember to take it!
50 yr. old female, diagnosed with Crohn's in small intestine and terminal ileum Sept-Oct. 2007. Also have IBS, and had Salmonella Dec. '07
currently taking Pentasa- 4 500mg pills per day, Metamucil and colace for constipation, probiotics

Regular Member

Date Joined Apr 2009
Total Posts : 166
   Posted 8/6/2009 9:40 PM (GMT -6)   
I am taking Salofalk, the Canadian version of Pentasa. I take 1000mg twice a day - in the morning when I get up, and at bedtime. I have been taking it that way since 2005, but my doctor recently told me that it doesn't matter how I take it. He said that I can also take it all at once at any time of the day. The important thing is taking the same dose at the same time of the day every day. I find that if I take it late I sometimes get a headache. From what I read, it is better to skip a dose than to take a dose late. Taking it with or without food is not really important because it passes through your stomach anyway, and goes to the ileum and beyond before the casing breaks up and releases the medication.

I would check with your pharmacist. They are much better at giving you information on medications often than the doctors.
44 years old. Diagnosed with moderate to severe Crohn's in April 2005. Hiatus hernia diagnosed in 2008. Had Crohn's under control until March this year when I had a major flare up and ended up in hospital. Diagnosis is now CD and IBS. Getting it under control again.
Currently taking: Prednisone 5 mg, Salofalk 2000 mg, Nexium 40 mg, Calcium and Vitamin D, Matamucil, Yogurt for probiotics, Salofalk suppositories as needed.

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