Humira - how long did it take to work?

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Regular Member

Date Joined Apr 2007
Total Posts : 89
   Posted 8/19/2009 4:00 AM (GMT -6)   
I've been on humira for 3 months now at one injection a fortnight - for the last month i've been on one injection a week & all this time been on steroids - & any drop below 40mg of steroids symptoms of crohn's are re-occurring.for the last few doses of humira i think i feel a bit better for a few days - more energy, less pain but then a few days before i'm due a shot i'm back to square one. Is the humira working at all or are the steroids doing most of the work? I've had a scope done recently showing severe inflammation - i don't know if the humira is a bit of a lost cause at this stage or if it can still kick in - how long has it taken to see a response in other people? - i'm going to my gi about this next wk but just want to be prepared! also anyone take the one a week injection with any other meds - like imuran etc & does it work better with them?

Rider Fan
Veteran Member

Date Joined May 2008
Total Posts : 1445
   Posted 8/19/2009 10:07 AM (GMT -6)   
It often takes 3 months to work, sometimes longer. However, given that you are on weekly shots and also on 40mg of pred you should be doing better than you are. I did read a recent study done by Dr. Sandbourne of the Mayo that showed Imuran and Remicade (and presumably Humira) works better than Remicade alone. Take care.

33 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. Proferrin iron pills.

Tried SCD, didn't work, now avoiding gluten and dairy.

Go Saskatchewan Roughriders!

Regular Member

Date Joined Jul 2003
Total Posts : 145
   Posted 8/20/2009 8:51 AM (GMT -6)   
My GI refuses to use immunosuppresants with biologics, he says it could lead to higher incidence of cancer. He says, given all its side effects, he would prefer to use steroids in combination. But, I don't know about effectiveness of these biologics in teh short term, I am due to take Humira next month, will post when I start it.

Veteran Member

Date Joined Apr 2008
Total Posts : 1753
   Posted 8/20/2009 10:52 AM (GMT -6)   
Mine took over three months to work. Up until it DID work I was still losing a lot of blood and feeling generally terrible. It gradually quit after a while though.
20 years old, Diagnosed with moderate to severe Crohn's and Colitis in May of 2008.
Currently taking: Prednisone 5 mg, pentasa 2 pills 4x a day, omeprazole in the morning, and a women's multivitamin. I'm also trying a B vitamin complex, but it doesn't seem to be working so I'm considering the shots.
Diet almost completely without refined sugars, wheat, flour, gluten, high lactose dairy, and/or junk food in general.
Learning how to live again.
"He who has a why to live for can bear with almost any how."

Regular Member

Date Joined Mar 2008
Total Posts : 176
   Posted 8/23/2009 6:17 PM (GMT -6)   

Hi Wild_Swan,

From what I understand, Humira can take from 3-6 months to work.  According to the Humira people, however, if it hasn't helped by 6 months, then it most likely won't be effective.

As for myself, I really had no idea if it was working or not (I'd been on it nearly 6 months at the time) until I had a colonoscopy and lo and behold the ulcerations were healed.  Unfortunately, I had scar tissue in my terminal ileum and ileocecal valve.  Thus, I had severe stricturing and had to have a small bowel resection.  Humira can reduce inflammation and heal ulcerations, but does nothing for scar tissue.

Prior to my surgery on 7/30, I used Humira once every two weeks.  (I'll start it up again soon).  I also noticed that about 5 days or so before I was do for my next injection, I experienced more Crohn's symptoms.

Hope the Humira ends up working for you!



54 year old female;
Have had Crohn's of terminal ileum for over 9 yrs.   My first small bowel surgery was on 7-30-09.
On Humira since Dec. 2008.  Allergic/hypersensitivity to Pentasa, Entocort, and 6-MP.  

New Member

Date Joined Nov 2008
Total Posts : 3
   Posted 8/25/2009 10:32 AM (GMT -6)   

Be careful with Humira! See my posts in:

It has caused so much more devastation than it has helped! Abbott and Humira are 2 names that will live in my heart as stealing my health, my dreams and the ability to feel normal forever! I hate Abbott and wish the 8.x billion dollars they made off of mine and others suffering would be donated to research a solution that really works!

Aimee =)
Veteran Member

Date Joined Jun 2004
Total Posts : 1020
   Posted 8/25/2009 9:02 PM (GMT -6)   
I really loved Humira - it kept me from surgery and I lived 99% symptom free for a full two years on it. At the time I started it, I wasn't eating anything solid and in and out of the hospital. I was eating solid foods within a week. I'm sure that is rare; I responded the same way with Remicade.

It doesn't sound promising that you're on high levels of both drugs and not doing any better. How discouraging =( I would perhaps give it until the 6 month mark?
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