Missed Remicade Infusion and EXTREME Stiffness/Migratory Inflammatory Arthritis

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New Member

Date Joined Jan 2009
Total Posts : 18
   Posted 8/25/2009 9:47 AM (GMT -6)   
I have been having Remicade infusions every six to seven weeks this year for severe CD now in remission since surgery in Feb. 
This last time I waited nine weeks between infusions.  At about six weeks started experiencing extreme stiffness, inflamation that moves around my body and what I call migratory inflammatory arthritis.  It moves and when gone leaves no trace except it strikes a new muscle, tendon or joint.  I could see the inflamation and see pinkness.  It moved randomly.
I had my remicade infusion on Friday.  My sed rate was 75 prior to infusion.  I walked in stiff and immediately after the infusion walked out just fine.  My stiffness left immediately after the infusion and has not returned yet.  I bet my sed rate is back to the 20s which is normal for me.
I tested negative for RA and am still awaiting results of ANA blood test for LUPUS.
Anyone else develop arthritis when delaying a remicade infusion a few weeks?
I scheduled my next remicade for six weeks as I do not want to go through that torture again.
Am I becoming overly dependent on Remicade? confused

Veteran Member

Date Joined Jun 2008
Total Posts : 1058
   Posted 8/25/2009 3:13 PM (GMT -6)   
The term for your problem is enthesitis and it seems to be associated with elevated TNF levels in the joints. I would suspect that the missed remicade may have caused a rebound effect resulting in an increase in circulating TNF in the blood. There is some suggestion that the inflammation could be due to formation of new blood vessels in the inflamed joint, thus the pinkness. Not much help, but at least you have a name for it.

Forum Moderator

Date Joined Nov 2003
Total Posts : 7056
   Posted 8/25/2009 4:46 PM (GMT -6)   
I had very similar experieces to your before EVERY Remicade infusion became due. I was initially started on Remicade not because of the severity of my Crohn's but due to the severity of my spondyloarthropathy [SpA] and associated enthesitis. Since that diagnosis, it has been determined that I have Ankylosing Spondylitis [AS]. AS and SpA are cousin diseases. Approximately 20% of people with Crohn's develop SpA.

Prior to starting Remicade, I could only get around using a cane and on bad days, a wheelchair. Remicade improved my mobility and therefore, my quality of life, in a multitude of ways. I didn't feel I was dependent on Remicade, rather that Remicade was a much needed medication that improved my health and quality of life.
Moderator Crohn's Disease  & Osteoarthritis Forums
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, asthma, severe allergy and a host of other medical problems.

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