Low Dose Naltrexone

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Crohnie_Mel
Regular Member


Date Joined Jan 2009
Total Posts : 23
   Posted 8/28/2009 11:25 AM (GMT -7)   
So I have decided after speaking with my other doctor and fellow crohnies that Cimzia is not worth it because of my track record with TNF Blockers.
 
Has anyone ever heard of or been on low dose naltrexone? Research has shown Crohn's patients have seen positive results from this inexpensive drug with little to no side effects to speak of! Is this too good to be true??
 
 
 
 
 
Melissa -- New York City
Diagnosed with Crohn's in 2004


not creative
Regular Member


Date Joined Mar 2007
Total Posts : 466
   Posted 8/28/2009 12:12 PM (GMT -7)   

I would try the Cimzia if I were you. I’m allergic to Remicade and Humira did nothing but Cimzia is working amazingly well. I don’t really know what about it made it so different from the other two but there is hope.

I also tried LDN and I have to say my experience with it was horrible. I had some of the worst dreams I’ve ever had (which for me is pretty bad as I have a lot of nightmares) because it made the dreams feel so real and tactile. It woke me up every morning at 2, 3, and 4am to have ridiculous diarrhea. It would be the only time during the day that I had D, but at 3am!? Sometimes I would be on the toilet for hours because the D would not stop. So much for sleeping in, I was always exhausted.

I also believe that because I was on nothing but the LDN, my unmedicatedness caused my disease to get worse and I ended up in the hospital with three huge abscesses that needed to be surgically drained. When I told the doctors at the hospital I was on LDN, they said that there is not enough actual evidence to warrant people with our fragile immune systems to experiment and they had never seen anything to convince them to allow their patients to try it…


Laurenne, 25 Graduate from University of California, Davis. BA-Anthropology
Dx'd w/ IBS and CD in 2002. Three abscesses that are now fistulas.
On: 6MP, 20mg Prednisone, Zoloft, Cimzia (working so well, I'm on Miralax too!)
Tried: LDN- Did nothing good, Remicade- allergic, Humira- no reaction


medchrt1
Veteran Member


Date Joined Sep 2005
Total Posts : 517
   Posted 8/28/2009 12:26 PM (GMT -7)   
I don't know. I always felt that a drug like lomotil supressed the pain (from the part called Diphenoxylate,,i.e. the narcotic part),as well as the codeine in tylenol w/ codeine but in the case of "the brief blockade of opioid receptors" that is indicated by naltrexone, just need someone to explain to me the difference between a narcotic and this naltrexone to even form an opinion.

EMom
Veteran Member


Date Joined Aug 2007
Total Posts : 990
   Posted 8/28/2009 2:10 PM (GMT -7)   
We have had lots of discussions here on the forum about LDN.  Here is a link to a few of them.  Scroll down to where you see "Low Dose Naltrexone"
 
 
It's my understanding, though, that LDN is not as effective if you have an underlying issue with candida.  For this reason, the docs who use LDN often recommend you follow a diet to kill candida overgrowth. 
 
The yahoo group for LDN users is a GREAT place to speak to others who use this treatment! Some people there have been on it for quite some time with great success.  Although many people there are using it for MS, there are plenty of Crohnies there too!  Good luck!  
 
 

Mom to 17 year old son diagnosed in June, 2007.
Omega 3s, digestive enzymes, probiotics, vit. C, calcium, vit. D3, a good multivitamin and SCD legal yogurt
Started The Maker's Diet in Sept. '07. Incorporate Specific Carbohydrate Diet (SCD) recipes, too. Med-free.
http://www.healingwell.com/community/default.aspx?f=17&m=984588
http://www.healingwell.com/community/default.aspx?f=17&m=1533705
http://www.healingwell.com/community/default.aspx?f=17&p=1&m=1262312


medchrt1
Veteran Member


Date Joined Sep 2005
Total Posts : 517
   Posted 8/28/2009 2:28 PM (GMT -7)   
In my previous post I of implied that naltrexone was opposite of the opiate.
I looked a bit farther on the mechanism for the naltrexone and found it instead mentioned with /regarding the bile salt production:

"Pruritus (itching) is the primary symptom of cholestasis and is thought to be due to interactions of serum bile acids with opioidergic nerves. In fact, the mixed opioid agonist/antagonist Naltrexone is used to treat pruritus due to cholestasis."

In other words, the point at which the naltrexone would be beneficial is for the condition of cholestasis (where where bile cannot flow from the liver to the duodenum).

ivy6
Elite Member


Date Joined Sep 2005
Total Posts : 10404
   Posted 8/28/2009 4:07 PM (GMT -7)   
Check out the medications thread in my sig. The formatting has gone a bit weird, so you may need to cut and paste the LDN URLs into your browser, but the info (if I remember rightly) is still fairly informative: it comes from the days when LDN was a very popular topic here on the forum.

:-)

Ivy.
Co-Moderator Crohn's Forum.

Medications for Crohn's ~~ Diet and Nutritional Therapy for Crohn's ~~ Dealing with Abscesses and Fistulae ~~

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