Ibuprofen = bad news for Crohnies? More info please!

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Aimee =)
Veteran Member


Date Joined Jun 2004
Total Posts : 1020
   Posted 8/29/2009 8:38 AM (GMT -7)   
I read in a pain killer post that we are supposed to be avoiding Ibuprofen but I am not sure why. I take it regularly, right now I'm using it to treat joint pain and intestinal pain that is not severe enough for the Vicodin my GI prescribed me. It works well for me.
 
He knows I'm on it but has never warned me against using it or told me another type of pain medication to take.
 
Can anyone fill me in on what they were warned about? What do you take instead?
 
Thanks!

Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 8/29/2009 8:45 AM (GMT -7)   
NSAIDS can cause bleeding and flares. I was using Ibruprofen for pain and it caused me to flare really badly. We are recommended to take either Tylenol or when that doesn't work prescription pain meds
Gail*Nanners* Co-Moderator for Crohns Disease and Anxiety/Panic Forum
Crohn's Disease for over 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium  w/Vit D, and Xanax as needed. Resections in 2002 and 2005. Also diagnosed with Fibromyalgia, Osteoarthritis, and Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
It's scary when you start making the same noises As your coffee maker.
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

pimfram
Veteran Member


Date Joined May 2009
Total Posts : 506
   Posted 8/29/2009 8:46 AM (GMT -7)   
From http://www.crohns.net/Miva/education/nsaids.shtml

In healthy people, the intestinal environment maintains a healthy balance, with anti-inflammatory proteins keeping pro-inflammatory molecules in check. In people with Inflammatory Bowel Disease - Crohns Disease and Ulcerative Colitis, however, the immune system can't calm the inflammatory response occurring in the gut. The result is damage to the intestinal lining, which also causes ulcers and increases the flow of intestinal contents, leading to diarrhea and bleeding.

In addition to causing chronic inflammation of the digestive tract, the immune response also accounts for the presence of disease beyond the intestine, as inflammatory cells are found in the joints, among other parts of the body.

In fact, arthritis is the most common "extra-intestinal" complication of Inflammatory Bowel Disease, affecting approximately 25% of people with Crohn's disease or ulcerative colitis. Although NSAIDs block prostaglandins, thereby reducing fever, pain, and swelling that prostaglandins cause, it's not necessarily a good thing for the gastrointestinal (GI) tract.

Prostaglandins play a useful role in the GI tract, where they have a protective effect on the mucosal lining of the gut. They can lessen the effects of cytokines, which are proteins released by the immune system, that produce inflammation.

Although NSAIDs can ease joint pain they can also cause damage to the mucosa in healthy people or reactivate the symptoms of disease in Inflammatory Bowel Disease - Crohns Disease and Ulcerative Colitis sufferers.
Diagnosed with CD July 2007
Currently on Remicade, Imuran, probiotics, folic acid, multivitamin.


FitzyK23
Veteran Member


Date Joined May 2005
Total Posts : 4219
   Posted 8/29/2009 10:08 AM (GMT -7)   
Unfortunatly we are not supposed to take it b/c it can cause bleeding and flares.  However, I recently injured my two big toes hiking and there was tons of gross swelling specifically around the nail.  The only thing that would help it was an anti-inflamatory.  In that situation it was the lesser of the two evils.  I took ibuprofin a couple times a day for a few days and so far I haven't had any gut trouble.  But I knew I was risking it doing that.   I couldn't walk b/c of the injury and figured I needed to get that fixed first even if it did cause diarrhea.  Sometimes ice and elevation just isn't enough.

27 Year old married female.  Graduated law school this year and waiting for results of the bar exam.  Start a new job sometime in September.  Diagnosed w/ CD 4 years ago, IBS for over 10 years before that, which was probably the CD. I am sort of lactose intollerant too but can handle anything cultured and do well w/ lactose pills and lactaid. For crohns I am currently on Pentasa 4 pills/4x day and hysociamine prn. I also have bad acid reflux and have been on PPI's since age 13. I have been through prilosec, prevacid, and nexium. Currently I am on Protonix in the morning and Zantac at night.  I take xanax prn for situational anxiety (aka no easy bathroom access). 


lilcrohnieUK
Regular Member


Date Joined Dec 2007
Total Posts : 414
   Posted 8/30/2009 5:44 AM (GMT -7)   

I've had two deaths in my family from use of NSAID's causing ulcers and perforation (to be fair they had both used them for a long time) so theres a reason we're told to avoid it, we're at a higher chance than your average person of having that happen to us too. you know I'm in a hell of a lot of pain if I have to resort to taking it which if I am suffering I will do, you know when pain gets to the point where you just don't care about the risks you just want some relief, but I know I'm helluva stupid to with Crohn's AND a family of history of dying in that way.

Because I take codeine everyday for bowel control (and have done for years) I've completely stitched myself up in terms of how I can be treated when I'm in pain, when I was last really ill they had me on morphine and pethidine and I still couldn't get relief.


 
 


txmark
Regular Member


Date Joined Apr 2009
Total Posts : 33
   Posted 9/1/2009 6:25 AM (GMT -7)   
My current GI (which is a Crohn's specialist at UNC) said all my problems are NSAIDs induced.  I was taking them for back pain and abdominal issues started shortly after.  The first GI said crohn's this GI says NSAIDs induced IBD/IBS.  He expects it to completly go away.....Through all my research of crohn's, IBS, and colitis I had never heard of NSAIDs induced IBD. 
 
I'm on my second flare in 18 months and this one has lasted 7 months so far.......I guess time will tell.

tsitodawg
Veteran Member


Date Joined Sep 2006
Total Posts : 845
   Posted 9/1/2009 6:41 AM (GMT -7)   
I have never heard of IBD going away and would find a new G.I. if one ever told me that. Did he possibly tell you that you do not have crohn's disease and your problems were caused by NSAIDs instead? NSAIDs do not cause Crohn's disease but can trigger a flare or cause bleeding which leads to other issues. Maybe I understood your post wrong, but was he possibly saying that you have crohn's disease and your flare should subside now that your are not using NSAIDS? IBD and IBS never go completely away but can be put into remission or controlled. IBD in particular is crohn's disease or ulcerative colitis and there are no known cures. I am not trying to be condescending or rude so please do not take it that way. Have you been given an actual diagnosis yet or are you still in the process? Sometimes it can take a while and a few different opinions to get a solid diagnosis. It took over a year and 2 surgeries to get a solid diagnosis for me. It started out as appendicitis, gallbladder, IBS and then finally confirmed Crohn's disease. Many here can probably share stories similar to mine about their diagnosis. If you have a doctor telling you that he is a specialist and your crohn's is going to go completely away and was caused by NSAIDS, then I really mean it that you need to change doctors. You also need to report them.

txmark
Regular Member


Date Joined Apr 2009
Total Posts : 33
   Posted 9/1/2009 12:30 PM (GMT -7)   

Sorry for the confusion.....the first GI I saw said I had crohns.  I was then referred to a crohn's specialist at UNC after 3 months of no "perceived" improvement.  The specialist doubted I had crohns based on the negative lab work and the biopsies from my colonoscopy were not conclusive.  So he repeated the colonoscopy and had me do a camera endoscopy.....both came back clear.

 

At that point he doubted that I had crohns and felt like it was more likely NSAIDs induced IBS or IBD (a condition that mirrors IBD but eventually goes away once the NSAIDs are removed).  So right now all I am being treated for is IBS and I don't feel like it is getting any better.

 

To note:  I only took 4 prescription strength NSAID (naproxen) in late December......flare started in 2 February, diagnosed with CD 10 Feb.

 

I probably should start a new post with my story and see if anyone has heard of anything similar. 


trishx
Regular Member


Date Joined Jul 2009
Total Posts : 25
   Posted 9/2/2009 3:35 PM (GMT -7)   
None of my surgeons over the years will allow NSAID s, not only do they cause the irrtation to the lining of the bowel, they change the flora. Patrick Holford's website in UK has some interesting facts on it. He actually believes that even for non CD patients it is a very harmful family of drugs

MoobyDoo
Regular Member


Date Joined Sep 2009
Total Posts : 212
   Posted 9/3/2009 7:29 AM (GMT -7)   
Wow. Thanks for that info everyone. I have given my Crohn's affected daughter Motrin this morning for pain because, well, it does help her tremendously. I guess I'll have to switch her to strictly Tylenol. Has anyone found that Tylenol helps with flare ups of painful stomach aches? I will stop the Motrin for sure, but hate to have to do that because it does work for her.

Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 9/3/2009 8:02 AM (GMT -7)   
MoobyDoo, yes do give her Tylenol instead of Motrin. For some the Tylenol does not work as well. If she is having the spasmy cramps, maybe you can ask her doctor for something like Bentyl or Levsin to help with the cramping. Good luck!
Gail*Nanners* Co-Moderator for Crohns Disease and Anxiety/Panic Forum
Crohn's Disease for over 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium  w/Vit D, and Xanax as needed. Resections in 2002 and 2005. Also diagnosed with Fibromyalgia, Osteoarthritis, and Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
It's scary when you start making the same noises As your coffee maker.
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*
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