New Member Ellice has a pg question

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Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 9/1/2009 10:48 AM (GMT -7)   
Hi everyone,

Brand new member and 2.5 year PG sufferer. Thrilled that I found this site and hope to learn from everyone. I live in Thailand and was basically abused by incompetent doctors for over 2 years. Three months ago I moved to a new town in the south of Thailand and am finally getting GREAT treatment. It looks like the nurses have finally cleaned my wound sufficiently that I am no longer infected. There is still pain, but it is mostly tolerable. My new doctor has me back on Prenidsolone even though it has never worked for me. She just wanted to start me from the beginning, so what can you do? It's been just over 2 months on this steroid and there has been a bit of skin growth, but it now has pretty much disappeared. I think it is time to go back on the dreaded Ciclosporone. I had success with this in the past, but the last attempt didn't work and I think that was because the wound was infected.

Today I went to see a skin graft doctor and he got me all depressed. He told me that my wound will likely never heal and if it does it will likely come back quickly and that I should just accept the fact that for the rest of my life (I'm 53) I will be in pain and will be changing bandages ever day. Anyway after reading some of the posts on this site, I've basically dismissed this and am starting to feel positive again. And that's a good thing.

So that is my first posting. Good luck to everyone out there.

Ellice
 
**Ellice I started a new post for you.  The one you posted on should have been locked because it is too long*

Keeper
Veteran Member


Date Joined Jun 2008
Total Posts : 1058
   Posted 9/1/2009 2:27 PM (GMT -7)   
Cleaning PG wounds can cause more problems, especially if they do "wound debridement" (scraping the necrotic tissue clear of the wound). Any injury to the wound results in worsening of the PG.

For a summary of common PG therapy, here is an extract from a paper:

Topical treatment is generally insufficient as monotherapy and used as supportive treatment for systemic treatment[12]. Topical treatment includes topical or intralesional corticosteroids, tacrolimus ointment, intralesional cyclosporine, topical 5 aminosalicylic acid, nitrogen mustard or 0,5% nicotine cream[2,13].

Systemic treatment is started in most of the cases with corticosteroids (e.g., methylprednisolone 0.5–1 mg/kg/d) or cyclosporine (e.g., 5 mg/kg/d) alone and considered as first-line therapy. Stabilization of the disease is usually achieved within 24 hours. For cases refractory to first line therapy with concomitant inflammatory bowel disease, second line treatment includes biological response modifiers and immunomodulatory therapy. Tacrolimus, thalidomide, azathioprine, dapsone, mycophenolate mofetil and infliximab are shown to be effective in case reports or small series. In cases without associated disease, intravenous immunoglobulins, granulocyte and monocyte adsorption apheresis plasmapheresis and cyclophosphamide treatment are also reported to be effective.

MMMNAVY
Veteran Member


Date Joined Jul 2006
Total Posts : 6927
   Posted 9/1/2009 3:36 PM (GMT -7)   
I have found that IV antibodics work best for me, because my crohns is not fully under control.
Forum Co-moderator - Crohn's Disease/Thyroid Disorders:_All comments have the caveat contact your local health care provider.

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Make sure your suffering has meaning…

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