Humira & Methotrexate What to expect

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Regular Member

Date Joined Nov 2004
Total Posts : 55
   Posted 9/3/2009 9:28 PM (GMT -6)   
Is anyone else out there taking two doses of Humira and 25mg injectible methotrexate a week?  Just wondering what to expect.  I have taken methotrexate before and have been on one dose humira a week for awhile now but not the two cobimned with the additional dose of Humira. 

Post Edited By Moderator (Nanners) : 9/4/2009 7:47:47 AM (GMT-6)

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 9/4/2009 8:47 AM (GMT -6)   
Hi Sarah,

Unfortunately I have never taken either of those meds, but I did want to direct you to our Crohns Resources above as Ivy6 made a link that discusses our medications. I also changed the title of your post, so that those on those meds can respond more. Good luck!
Gail*Nanners* Co-Moderator for Crohns Disease and Anxiety/Panic Forum
Crohn's Disease for over 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium  w/Vit D, and Xanax as needed. Resections in 2002 and 2005. Also diagnosed with Fibromyalgia, Osteoarthritis, and Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
It's scary when you start making the same noises As your coffee maker.
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Regular Member

Date Joined Feb 2008
Total Posts : 314
   Posted 9/4/2009 9:55 AM (GMT -6)   
Hello my names Chris. And Ive been taking Humira and Methotrexate for about a year and a half now. And I was taking methotrexate alone for about another 9 months prior to that. And I havent had a major flare since really. And I have pretty severe Crohns disease, 5 major resections, 23 outpatient surgeries and probably a dozen ER visists a year on average, and admitteda bout 4 times a year on average sometimes much more though. so I have it pretty bad, but I really havent had a major flare since really. I have felt bad a few times and been admitted but its been a really good year and a half for me. Now at my hospital Ive been so many times for so long that I know most of the drs and they know me by name and all, most of them and the nurses whether in the ER, on the floors after being admitted or even the x-ray techs will be like oh chris how have you been havent seen you in a while guess thats a good thing. So it really has been better since being on both. Some people, lots of people actually dont think you should or are scared to take 2, but its actually becoming more and more common. For me I found that the methotrexate worked really well for me in my small bowel and even with acid reflux well, but i still had some rectum and lower colon pain, and that really helps taht out, i knw it doesnt make sense at all that Methotrexate would only help the upper portion basically because it affects the immune system entirely not an organ like a pill does or anything, but for some reason thats where it helped me. I actually think that me and my doctor count methotrexate as one of the best drugs for me, and Ive tried most of the drugs out for crohns that are on the stronger end(and theres only a couple listed on that list, like prednisone and methotrexate and maybe one or two more).

Anyways, What I found also is I dont really experience any side effects with it. I know that the first biologic I had tried was 6mp, but it affected me significantly by making my blood counts low and white counts high and i had to be isolated and get hemoglobin and hemocrit i believe weret he two, one i got once a week and one i got daily to fix what the 6mp did, so I cant take that anymore, nor can i tolerate and think similiar like Imuran.

So when I had gone to one of my GI, my local GI, (and I keep a GI at a university hospital in Richmond, Va, my capital), me and him decided that I would get my first couple of injections of methotrexate in the office and wait no shorter then 30 minutes afterwards to see if he noticed anything change or if i felt certain things. the first time i got it it gave me a headache and i felt like i had a tight chest, but honestly i think it was just anxiety of trying another biologic drug like the 6mp after what it did to me. Headaches were pretty bad. I waited in the office for I think 3 times, and the 2nd and 3rd day i had no symptoms. The only symptom I eventually got was off and on headaches, I was already going to a pain management dr at the time so I told him about it and he gave me fioricet(spelling) , the non-codeine version, with just barbiturates, tylenol and caffeine i believe. Anys they really helped me quite well, I would just take one prior to taking my injection and that stopped them completely. I never had side-effects with the humira at all though which i good i like, I do which the injection pen was different like a normal/regular needle. I actually only needed that fiorinal for about 6 to 8 months of the injections and off and on and sometimes not at all. I know that my dr gave me a prescription of 45 in a bottle i think, and basically when i ran out it got refilled because he gave me refills. I actually dont think i even got to the 2nd script or i might have just got the 2nd script but they lasted me a while and worked well, I praise fiorinal its really good medciation for headaches. I think its actually labeled as for tension headaches but i think their used on all and other things also off-label.

I hope you do this and have as good luck as Ive had with it I really do. I know how hard it can be to find the right combination of medications, can take years, literally to find. You might find one that works but have 7 others taht dont you dont know if they do.

by the way can I ask why your taking the humira weekly and not bi-weekly AND also taking the methotrexate? I can understand , ok maybe you need the humira weekly, but then why would your dr give you methotrexate and ALSO double your himira by giving a whole entire other injection of humira? Why does he not just keep you at the weekly humira, give you the methotrexate and give it like 3 months to see how iworks/affects you and such and then make a decision based on how your doing, on whether he needs to go on up to 2 doses of humira a week. That sounds like the best way to do it I would think. And if he hasnt said hes doing this, and just thinks eventually he thinks he'll be at 2 doses of humira a week also then ok, but I wouldnt want to go up and start a new.

I would bring it up to your Dr that you would like to start the methotrexate like he wants but you would like to just stay at the humira weekly and see how it makes you feel in say 3 months, so it gives enough time for the methotrexate to kick in, and then make a decision based on how you feel and test results at that point if you need to go to 2 doses of humira a week. Because do you realize if you went to 2 doses a week that would be quadruple or 4 times the amount of the normal Crohns patient or any paitients normally gets? I mean that almost sounds dangeroug, if he recommends it then it must not be and you should trust him, just sounds to the ear like qute a lot, but you know if the 'recommended' dose of what they say works for most people is at this number and your taking 4 times that number plus ANOTHER medication to do the same thing....then wow thats consierable.

I give you praise for being 'brave' as some would think like me, and diving into the world of 2 biologics. Its really becoming more common as I was saying, its more common to see someone taking Remicade and another immuno-suppresent. I believe the most common biologics used in combination with another are Humira, Remicade, Methotrexate, usually if someone is taking 2, then atlest one of them is one of these 3, if not both of them being one of these 3. Its just reseerved for an agressive form of the disease in which most people get 2.

Goo luck and I hope you do well I reaaaaallly ramble lol. sorry Im bored. and found it interesting that your going to take the same 2 as me which i havent come across anyone else like that, more or less many with 2 period. wanted to addd my 2 cents, figured most wouldnt know about it from experience or might disagree with using two biologics so i figured a more postitive view is always needed and thats usually me thats chimes in in that situation. such as applying for disability is always a neagative experience post, so i telll my postive experience story lol.

Thanks for listening to my bull sarah and who all is reading. My name Chris by the way Sarah if i ddnt mention it in here


Elite Member

Date Joined Sep 2005
Total Posts : 10404
   Posted 9/4/2009 5:29 PM (GMT -6)   
This is just an idea, but if you inject your Humira on, say, Friday, you might like to get your Methotrexate on Monday or Tuesday.

Getting your mtx on the day that your Humira usually starts to wear off might just give you an extra day or two of relief before you inject the Humira again.

It might be a good idea to talk with your doctor about this. S/he might, instead, want you to get all three injections on the same day, to super-charge the effect of the meds.
Co-Moderator Crohn's Forum.

Medications for Crohn's ~~ Diet and Nutritional Therapy for Crohn's ~~ Dealing with Abscesses and Fistulae ~~

Regular Member

Date Joined Nov 2004
Total Posts : 55
   Posted 9/7/2009 10:27 PM (GMT -6)   
Chris-I was taking Hunira bi-weekly but it wasn't enough, so I have been on weekly injections for at least a year now. And now that isn't working, so I am guessing that is why he is upping it to 2 shots a week and adding methotrexate. He is bringing me down on doses of the methotrexate in 4 week intervals. I am at 25mg now and in 4 weeks I go to 20mg and so on until I reach 10mg. I will stay on 10mg until further notice from him. I cannot take Imuran, it gave me panceatitis (sp?) and I was on remicade and methotrexate for almost a year but stopped that so I could have a baby. After my son was born I tried to go back to remicade but built up antibodies to it. I am assuming he is being so aggressive because it is affecting my esophagus right now. I also have it in my stomach and throughout my large intetestine and my rectal opening. Thank you for your thoughts and info!
Ivy-I am taking the Humira on Monday nights (I am off work on Tuesday) and the methotrezate on Friday nights so I have the weekend off of work and my family is around to help me with my 2 year old son since my husband works 6 days a week.
Diagnosed Sept. 2004 (two weeks before my wedding)
Currently on 80mg Humira, Prevacid, Methotrexate 25mg and Folic Acid
Have also taken Entocort, Remicade, Pentasa and Imuran

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