Zosyn and Flucanozole

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NostraHistoria
Regular Member


Date Joined Nov 2008
Total Posts : 351
   Posted 9/14/2009 6:26 PM (GMT -7)   
I am in a flare and have one big abscess and a few smaller ones. Apparently, they put me on Zosyn and Flucanozole to treat the abscess. One of these drugs has stopped the bleeding I have had for everyday for 15 months. Not sure which one. However, I am really, really tired. I want to sleep and rest all day. When I go to sleep around 12:00 AM, I wake up 2-3 times every 2 hours or so to have a bowel movement. I do not get much sleep. So, during the day, I have to sleep. However, I still get some blood from my hemorrhoids sometimes. Today I had one BM with quite a bit of blood loss. I am anemic. My white blood cell count is around 10.3 usually, but it dropped all the way to 7 during the hospital stay. Who knows what it is now. I have not been very tired usually like I am today.

I am wondering now what is making me so tired. Lack of sleep? Zosyn? Flucanozole? Blood loss? Anyone have any input on this?
26m - Dx January 2005: UC/Crohn's
Normal medication: 12 tablets of Asacol daily
New: Entocort 9 mg


Keeper
Veteran Member


Date Joined Jun 2008
Total Posts : 1058
   Posted 9/14/2009 9:48 PM (GMT -7)   
Zosyn can cause sleeplessness and Flucanazole can cause fatigue. The combination is obviously bad for your energy level. Low iron probably contributes to this also. Are you sure it wasn't the Entocort that has helped your bleeding? It does a pretty good job on GI bleeding.

If one of the two other drugs stopped your bleeding, then the bleeding probably was caused by bacteria or fungi since these two are an antibiotic and a fungicide. Once you get the bleeding under control and your inflammation reduced, you should be able to improve your iron levels.

njmom
Veteran Member


Date Joined Apr 2006
Total Posts : 1884
   Posted 9/15/2009 5:29 PM (GMT -7)   

In July 2006 "just in case" my daughter had a bacterial infection, the GI at the hospital ordered Zosyn for her - it made her Crohn's symptoms worse, resulting in cramping. Perhaps your docs should consider meds that help the abscess, but are not problematic for Crohn's. Flagyl and Cipro can, for instance, be used to try to treat an abcess without making Crohn's worse.  

There is a slight potential for an adverse drug interaction between fluconazole and Entocort:

"Fluconazole may block the breakdown of budesonide by the liver. If this happens, blood levels of budesonide could be increased. This may cause an increase in both the intended effect and the side effects of budesonide, including stomach irritation, facial swelling, and mood changes. If these drugs are used together, your doctor may want to monitor you closely for side effects and adjust the dose of budesonide if needed.Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems."

http://www.drugdigest.org/wps/portal/!ut/p/c1/fY3dEkJQFIWfxRPsHfm7lAYHB1MUbowaI8UhDJOnjweote7WzLc-SGEty6eqzMeqZXkNMaRSJqCJaOokQoMISBSLKq52WtcdXDdCyvBHNATPapsCEkjlnz8KDxfW9s3mm6pihhBi3GfnJ3bUHRhdVD8IqUjCu8wv-mi7iUMMfzjayehG5YRkCZaoJr1q0fHziA7xzXPeGset1uSvtXuxeY5F7QsKuZeN/dl2/d1/L0lJZ2tsZyEhL3dIRUJKRXRRQmxBIS9ZSTU0NTAtdy83XzMwRzAwR0NJVTBGSTMwSThITThMQVIzMDgy/?drugList=550830&cD=550830&cD=266&dN=Entocort+EC+Capsules%5EFluconazole+Tablets%5E&step=check&CheckFDA=1

 

 

Post Edited (njmom) : 9/15/2009 6:36:00 PM (GMT-6)


NostraHistoria
Regular Member


Date Joined Nov 2008
Total Posts : 351
   Posted 9/16/2009 6:59 PM (GMT -7)   
Keeper said...
Zosyn can cause sleeplessness and Flucanazole can cause fatigue. The combination is obviously bad for your energy level. Low iron probably contributes to this also. Are you sure it wasn't the Entocort that has helped your bleeding? It does a pretty good job on GI bleeding.

If one of the two other drugs stopped your bleeding, then the bleeding probably was caused by bacteria or fungi since these two are an antibiotic and a fungicide. Once you get the bleeding under control and your inflammation reduced, you should be able to improve your iron levels.


Are you a doctor or nurse?

I have been using Entocort since September 2008 off and on. I am positive that it did not stop my bleeding. If you are right that bacteria or fungi caused the bleeding, then I am wondering why I was not given the drugs last year when I was in the hospital with a similar condition. Infectious disease doctors came to me in the hospital this last time. As far as I know, they put me on Zosyn to treat the abscess. As for flucanozole, I am not sure why they put on it, as well as Protonix. The nurse who comes to my home to draw my blood each week said that the infectious disease doctors do not say much. One ID doctor came by and probably said 5 words to me and left.
27m - Dx January 2005: UC/Crohn's
Entocort 9 mg, Zosyn IV 4.5g x 3, Flucanozole 200mg, Asacol 4 x 3


NostraHistoria
Regular Member


Date Joined Nov 2008
Total Posts : 351
   Posted 9/16/2009 7:06 PM (GMT -7)   
njmom said...
In July 2006 "just in case" my daughter had a bacterial infection, the GI at the hospital ordered Zosyn for her - it made her Crohn's symptoms worse, resulting in cramping. Perhaps your docs should consider meds that help the abscess, but are not problematic for Crohn's. Flagyl and Cipro can, for instance, be used to try to treat an abcess without making Crohn's worse.

There is a slight potential for an adverse drug interaction between fluconazole and Entocort:



"Fluconazole may block the breakdown of budesonide by the liver. If this happens, blood levels of budesonide could be increased. This may cause an increase in both the intended effect and the side effects of budesonide, including stomach irritation, facial swelling, and mood changes. If these drugs are used together, your doctor may want to monitor you closely for side effects and adjust the dose of budesonide if needed.Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems."

http://www.drugdigest.org/wps/portal/!ut/p/c1/fY3dEkJQFIWfxRPsHfm7lAYHB1MUbowaI8UhDJOnjweote7WzLc-SGEty6eqzMeqZXkNMaRSJqCJaOokQoMISBSLKq52WtcdXDdCyvBHNATPapsCEkjlnz8KDxfW9s3mm6pihhBi3GfnJ3bUHRhdVD8IqUjCu8wv-mi7iUMMfzjayehG5YRkCZaoJr1q0fHziA7xzXPeGset1uSvtXuxeY5F7QsKuZeN/dl2/d1/L0lJZ2tsZyEhL3dIRUJKRXRRQmxBIS9ZSTU0NTAtdy83XzMwRzAwR0NJVTBGSTMwSThITThMQVIzMDgy/?drugList=550830&cD=550830&cD=266&dN=Entocort+EC+Capsules%5EFluconazole+Tablets%5E&step=check&CheckFDA=1




</P>
</P>


At first, the doctor in the ER put me on IV flagyl and cipro. I told him that I got Crohn's/UC after I used cipro, but he still put me on it. Then, the colo-rectal surgeon took me off cipro. When the Zosyn started is something I do not remember. They took me off Asacol and Entocort in the hospital. After a few days my stomach hurt really had. After I was put back on them, I felt better. I am pretty sure that Zosyn is causing me diarrhea. If not Zosyn, then it is the flucanozole. One of these is also making me have more a lot more bowel movements.

I just recently got the medical records from the hospital, and one of the abscesses I have was 6.2cm by 2cm or so. That is pretty big. The smaller ones were around 2x2cm. The thing that is getting me mad is that the colonoscopy I had last year stated that I had crypt abscesses, but my GI did not do anything about it or even tell me. I only found out about 4 months later when I went to another doctor and she asked what I had done about the abscesses.
27m - Dx January 2005: UC/Crohn's
Entocort 9 mg, Zosyn IV 4.5g x 3, Flucanozole 200mg, Asacol 4 x 3


njmom
Veteran Member


Date Joined Apr 2006
Total Posts : 1884
   Posted 9/16/2009 8:43 PM (GMT -7)   
I do hope your abcesses clear up. The body "hides" iron when there is an infection, so it is possible that when the infection clears up, your iron status will improve.

NostraHistoria
Regular Member


Date Joined Nov 2008
Total Posts : 351
   Posted 9/16/2009 9:36 PM (GMT -7)   
The thing that stinks is that if I have the CT scan next Monday and it is still there, it is surgery. The colorectal surgeon said that he would remove the diseased part of the colon. I am not sure if he meant the part with the abscesses or the part that has the crohn's/UC. It seems like surgery will be the best option to prevent cancer, because I was told that I will die from cancer anyway because my testicle would not descend when I was around 2 or 3.
27m - Dx January 2005: UC/Crohn's
Entocort 9 mg, Zosyn IV 4.5g x 3, Flucanozole 200mg, Asacol 4 x 3


andrealeigh71
Regular Member


Date Joined Sep 2009
Total Posts : 96
   Posted 9/20/2009 7:20 AM (GMT -7)   
Ask your pharmacist---make sure you have a good relationship with your pharmacist. They can be the best resource out there!
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