vedolizumab in Phase III trials

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Veteran Member

Date Joined May 2006
Total Posts : 1177
   Posted 10/10/2009 4:49 PM (GMT -6)   
vedolizumab a new biologic (a different type of biologic than remicade, humira, and cimzia), is apparently now in phase III clinical trials for crohn's and ulcerative colitis the next 2 years. Apparently they have high hopes for this one, because is it works, according to takeda, the manufacturer, "Unlike existing IBD therapies, the unique gut-selective targeting of vedolizumab has the potential to benefit IBD patients without compromising systemic immune function."

Is anyone on this board participating in this trial? If you aren't finding much improvement from existing therapies, perhaps you can ask your GI about this trial.

I can't wait for more drugs to become available for crohn's and UC. I hope this drug will be great, and will be on the market within the next 4 years.

If anyone has more information, please add to this thread.

Husband with Crohn's
Diagnosed March 2003 Ulcerative Proctitis
Diagnosed March 2008 Crohn's & C-diff, hospitalized 45 days
Canasa, Lialda, Remicade, VSL#3, Florastor
In Remission since June 2008
Stopped vancomycin for c-diff Jan 1 2009
C-diff free, until Sep 2, 2009
Fighting c-diff, I guess for life

Regular Member

Date Joined Dec 2007
Total Posts : 414
   Posted 10/11/2009 8:14 AM (GMT -6)   
It always interests me to hear of new drugs and treatments, to think 7 years ago Infliximab was my last shot before surgery for an ostomy and now theres all these other options - gives me so much comfort! This one sounds particularly interesting, will be keeping an eye on this thread for more info!

Veteran Member

Date Joined Apr 2006
Total Posts : 1884
   Posted 10/11/2009 3:35 PM (GMT -6)   
"without compromising systemic immune function" sounds good to me. 
Daughter (22) Dx'd Crohn's 3/06. Misdiagnosed for two years, including by top pediatric Crohn's specialist as stress. No symptoms for the past two years. Recent colonoscopy shows stricture gone but still two spots of inflammation in TI. On Entocort since April 06. Never had D. Now using LDN to taper off Entocort. SCD multivitamin, homemade yogurt, 2000IU vitamin D3, 900+ mg calcium, 25 mg iron, monthly B12 shots, Krill capsules, occasional zinc. SCD diet modified to include potatoes and rice. 

Veteran Member

Date Joined May 2009
Total Posts : 703
   Posted 10/11/2009 9:06 PM (GMT -6)   
Good to hear it's more specifically targeted; that'd be a huge plus. If I recall, ustekinumab (Stelera) is more specific and targets adhesion when cells (neutrophils) cross into the GI tract.
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