Post Edited (FunGuy) : 10/13/2009 10:52:26 PM (GMT-6)
When ATP binds to P2X7 receptors it facilitates a rapid bi-directional flux of cations thereby triggering depolarization, collapse of the Na+ and K+ gradients, and massive influx of Ca2+. Furthermore, continued stimulation of P2X7 receptors causes formation of large, nonspecific pores, allowing permeability of molecules up to 800 Da via recruitment of a distinct pore-forming moiety (Zanovello et al, 1990, Zheng et al, 1991, Surprenant et al, 1996). I don't know what half of the above means but there is Na and K in gatorade. Emaphasis added by me.
NOW LOOK AT THIS BELOW!
0006]High activity of P2X7 receptor has been found to be implicated in epithelial cancer (Coutinho-Silva et al, 2005), leukemia (Zhang et al, 2004), brain tumors (Guo et al, 2004), spinal cord injury (Wang, 2004), tuberculosis (Mancino et al, 2001), Alzheimer's Disease (Parvathenani et al, 2003), neurodegenerative diseases generally (LeFeuvre et al, 2002), autosomal recessive polycystic kidney disease (Hillman et al, 2004), diabetes, including type I diabetes (Elliott and Higgins, 2004), prostate cancer (Slater et al, 2004), osteoporosis, bone formation and resorption (Ke et al, 2003), rheumatoid arthritis, multiple sclerosis, myasthenia gravis, Crohn's disease, Septic shock, and periodontal infection (Muhl et al., 2003).
HERE IT IS!! High activity of P2X7 implicated in Crohns. ATP activates P2X7. Blue 1 inhibits ATP form activating P2X7. The Blue1 doesn't need to pass through the bowel, it is applied DIRECTLY to the ulcerations in the bowel when I drink it!! Do you see why I am so excited here!? Fact is I hope it doesn't pass through the bowel as I am afraid of it's ability to pass into the brain.
The above info is from http://www.faqs.org/patents/app/20090215727#ixzz0TYU10qN9
Post Edited (FunGuy) : 10/15/2009 10:02:40 AM (GMT-6)
Post Edited (FunGuy) : 10/16/2009 8:14:30 AM (GMT-6)