Article on IBD markers

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Date Joined Feb 2009
Total Posts : 1810
   Posted 11/7/2009 5:06 PM (GMT -6)   
Here is a link to a great article on IBD markers for crohn's disease in case anyone is interested. Sounds like the test is pretty darn accurate and the antibodies may be present before disease is even present. I am taking a copy to my doctor and nurse practitioner who diagnosed me as having some other kind of colitis-:) yeah
diagnosed 1/09 with "diverticular colitis" ?? location: sigmoid colon
localized scleroderma & IBS, low thyroid,claritin, advair, singulair, benicar
 50 +  female
 colazal, fish oil, synthroid, zoloft, wellbutrin, VSL#3 probiotic.
Blood test positive for Crohn's via prometheus ibd serology panel

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Date Joined May 2009
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   Posted 11/7/2009 5:55 PM (GMT -6)   
Pretty interesting. It'll take me a while to digest it. I recently asked my GE if they could tell if somebody had CD just by looking at their blood. I've also recently been wondering what's different (e.g. blood) among sufferers of various autoimmune diseases. Seems like it might be interleuken levels. Or just unknown at this point. I did recently read something about a trial where CD patients had their blood filtered (of neutrophils?), similar to dialysis.

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Date Joined Nov 2003
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   Posted 11/7/2009 6:30 PM (GMT -6)   
The PROMETHEUS® IBD Serology 7 test is used to look for these markers in the blood. Please be aware that some insurance companies will not pay for this test. I believe it costs between $400-500. Someone that has had this test can correct me on the cost.
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CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, asthma, severe allergy and a host of other medical problems.

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Date Joined Jun 2008
Total Posts : 1058
   Posted 11/8/2009 12:44 AM (GMT -6)   
Antibodies for bread yeast (Saccheromyces Cerevisiae) are not the key to predicting CD. Bread is probably the most common food eaten in many of the countries of the world. All it takes to generate antibodies for bread yeast is increased gut permeability. The bread eaten with increased gut permeability will provide yeast that can then cross into the bloodstream via the permeable gut. This will result in antibodies to bread yeast - wheat gluten antibodies happen in the same way. Stress is a known source of increased gut permeability and the blood samples were taken from soldiers being inducted into the Israeli military - most of them would be under stress. I can't say that I am convinced that this means much.

On reading further, I see that the study did not test the general population for yeast antibodies - just those who later got a diagnosis of Crohn's or UC. This does not really test the usefulness of yeast antibodies as a predictor of disease development, since they have not shown that those who did not develop the illnesses also did not have yeast antibodies. They also don't seem to understand that gut permeability is not a permanent state. They tested for permeabilty on patients who had the antibodies and found little permeability. From that they decided that the antibody formation and gut permeability were separate manifestations of the disease - that is they are not directly related. This ignores the probability that antibodies formed during an episode of permeability and persisted. Antibodies to cells with cell walls like a yeast has persist for over 20 years. Fuzzy thinking if you ask me.

Post Edited (Keeper) : 11/7/2009 11:05:40 PM (GMT-7)

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Date Joined Nov 2009
Total Posts : 3
   Posted 11/11/2009 5:43 AM (GMT -6)   
HI I noticed in your post that your prometheus serology came back positive for crohns. Can they diagnose crohns from that simple blood test??? I really need to know. I just had that test done.  Thx Dar
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Post Edited By Moderator (Nanners) : 11/11/2009 7:09:01 AM (GMT-7)

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Date Joined Feb 2009
Total Posts : 1810
   Posted 11/11/2009 8:58 AM (GMT -6)   
Dar, I don't think many docs would diagnose you just on the basis of a blood test.  I was reading comments others left and they do raise some good points. It is interesting that it is an antibody to a yeast and certainly could provoke some interesting postulations about why this is so. Certainly, gut permeability seems a likely explanation but that probably only happens if you have some degree of inflammation. While biopsies go to the microscopic level, there could be chemical messenger problems that biopsies cannot see.  The study, while small, did not find any positives in the normal (control) group. It would be nice to see a larger study. Many use these tests as a predictor of disease severity from what I read, especially in the pediatric population. It is interesting to chat about though.
diagnosed 1/09 with "diverticular colitis" ?? location: sigmoid colon
localized scleroderma & IBS, low thyroid,claritin, advair, singulair, lisinopril, progesterone, colazal, fish oil, synthroid, zoloft, wellbutrin, VSL#3 probiotic, Vit. D
Blood test positive for Crohn's via prometheus ibd serology panel

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