vaccine hazard?

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

njmom
Veteran Member


Date Joined Apr 2006
Total Posts : 1884
   Posted 11/13/2009 8:11 AM (GMT -7)   
Is this abstract saying what I think it says, that a chemical now used in vaccines activates internal cell tripwires, leading to inflammation??? 
 
"...a chemical long used to boost the effectiveness of vaccines might work by activating one of the cell's internal tripwires. This insight could lead to the production of better, safer ingredients for future immunizations."
 
 
"Cell Biology:

Internal Affairs

Mitch Leslie

To keep watch for internal intruders, a cell deploys a cytoplasmic surveillance system that parallels the one detecting menaces outside of its membrane. When infiltrating pathogens trip one of these alarms, the cell retaliates with measures that range from instigating inflammation to committing suicide in a way that alerts other cells to the threat. In turn, microbes have evolved a plethora of countermeasures to disrupt, deceive, and dodge these intracellular weapons. The medical importance of our cells' internal defenses goes beyond battling pathogens. Errant responses by these alarm systems underlie illnesses such as gout, Crohn's disease, which is a type of intestinal inflammation, and the lung deterioration provoked by asbestos. Some of what scientists have learned about the mechanisms of such diseases has already made it to the clinic: The discovery that faulty microbial receptors inside the cell are behind several rare but debilitating "fever syndromes" inspired a successful new treatment for those conditions. Researchers have been testing the same drug against gout. Furthermore, scientists have just realized that a chemical long used to boost the effectiveness of vaccines might work by activating one of the cell's internal tripwires. This insight could lead to the production of better, safer ingredients for future immunizations."


Keeper
Veteran Member


Date Joined Jun 2008
Total Posts : 1058
   Posted 11/13/2009 3:27 PM (GMT -7)   
It sounds odd that a vaccine which is external to cells is potentiated by a reaction internal to cells. Maybe it is some kind of stimulus to chemoattractants produced by that cell. It really is not obvious just what the result of this "tripwire" activation would be.

njmom
Veteran Member


Date Joined Apr 2006
Total Posts : 1884
   Posted 11/13/2009 4:32 PM (GMT -7)   
The full article says that the chemical approved as an "adjuvant" (something that boosts the pharmacological effects of the vaccine) in the US for vaccines is aluminum hydroxide, or alum.
 
"It can boost immunity, but also trigger fever and other side effects. One obstacle blocking vaccine improvements is that researchers didn't know how alum tweaks the immune system. But some recent studies suggest that alum provokes the inflammasome. If so, researchers might be able to fine-tune adjuvants to induce a strong inflammasome response while provoking fewer side effects."
 
It seems like they haven't figured out whether this adjuvant, in the vaccine, is good or bad for Crohn's.
 
 
New Topic Post Reply Printable Version
Forum Information
Currently it is Tuesday, December 06, 2016 2:50 PM (GMT -7)
There are a total of 2,733,707 posts in 301,145 threads.
View Active Threads


Who's Online
This forum has 151278 registered members. Please welcome our newest member, northerner.
387 Guest(s), 18 Registered Member(s) are currently online.  Details
cupcakespinkgal, Alcie, ewafromwarsaw, KAR90, Rikky1, northerner, NiceGuyEddie, Tick41, Hoshie, Huddie, pmm73, maria2016, FL, dbwilco, Hilander64, snowboat, gilly2, julymorning


Follow HealingWell.com on Facebook  Follow HealingWell.com on Twitter  Follow HealingWell.com on Pinterest
Advertisement
Advertisement

©1996-2016 HealingWell.com LLC  All rights reserved.

Advertise | Privacy Policy & Disclaimer