Humira and 6 MP

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Regular Member

Date Joined Jul 2009
Total Posts : 83
   Posted 11/16/2009 12:50 PM (GMT -6)   
Hi all -
Wondering if it is safe to, or if anyone does, take Humira AND 6 MP?
**32 year old female; Diagnosed with ulcerative colitis in 2001; diagnosis changed to Crohn's disease in 2009 (but still only impacts colon)
**Asacol (4800 mg daily), 6-MP (100 mg daily), Prednisone (10 mg daily...for a few more weeks), Nexium (40 mg daily)
**Previous meds: Colazal (allergic); Flagyl (off and on for rectal inflammation); Rowasa (enemas only when needed); various pain meds (but luckily none lately); iron IV infusions (when hemoglobin gets low)
**Thankfully only two major flare-ups...2001 and 2009. Hoping to have another 8 years in between the next one (sadly, I do know there will be a next one).

Veteran Member

Date Joined May 2006
Total Posts : 1177
   Posted 11/16/2009 10:11 PM (GMT -6)   
I think taking both increases risk of some cancers . . . by a slight degree. That's pretty much all I know about taking 6-mp with humira.

I know plenty of people with rheumatoid arthritis take mtx + remicade/humira/enbrel/cimzia/orencia . . . in fact, I think with RA, mtx is pretty much a given, and if that doesn't help, they add on a biologic. So, it certainly isn't unheard of to take a biologic with another immune suppressant (such as mtx, or 6-mp or imuran). I think there are other people on the crohn's board who are also taking a biologic + an immune suppressant (6-mp/imuran/mtx).

My husband who is currently struggling with possible IBD related arthritis, is likely looking at adding mtx to control the arthritis, in addition to the remicade that he is already on. So, it isn't unheard of, to mix 2 such meds together. Yes, it does increase the risk of certain side effects. . . but when you have crohn's, you live in the little spot that is between a rock and a hard place . . . so I'm sure you understand that sometimes we just have to take our chances.

Husband with Crohn's
Diagnosed March 2003 Ulcerative Proctitis
Diagnosed March 2008 Crohn's & C-diff, hospitalized 45 days
Canasa, Lialda, Remicade, VSL#3, Florastor
In Remission since June 2008
Stopped vancomycin for c-diff Jan 1 2009
C-diff free, until Sep 2, 2009
Fighting c-diff, I guess for life

Regular Member

Date Joined Apr 2007
Total Posts : 40
   Posted 11/17/2009 10:21 AM (GMT -6)   
MY GI is a medical professor. He had me on humira and 6mp for a month when I stared humira. But he said it was his job to get me by on as little medication as possible, so he stopped the 6mp after I finished the humira starter doses. I think your gi has a plan and you should ask him.
Crohns dx in 2002. ilieum and colon resection 2002. Ilieum resection 2007.
Started Humira dec, 08

Veteran Member

Date Joined Aug 2008
Total Posts : 5852
   Posted 11/17/2009 1:50 PM (GMT -6)   
     I start Remicade tomorrow.  My GI doctor took me off the 6MP two weeks ago.  I was only taking 50 mgm as the 100 mgm dose lowered my white count to 1.6!!!  It is now up to 4.0.   I've had ulcerative proctitis for 11 yrs and all my options are exhausted except for Remicade, Humira and Cimzia.
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008 for ten days.
Remission Nov 08 thru May of 09.
Flare May of 09 thru Aug of 09.  Meds: Colazal, 6MP, prednisone taper, probiotics, Benicar, calcium and multivitamin
Remission...too short...Sept and Oct.  Now in bad flare again...blood and mucus...back on prednisone, off the 6MP, waiting for approval from ins co to start Remicade.

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