Another Drug in the pipeline - Trafecit

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Former58D
Regular Member


Date Joined May 2009
Total Posts : 173
   Posted 11/26/2009 8:13 AM (GMT -7)   

Seems like there are more every couple months........good news.

[*I just activated the link - C2]

Post Edited By Moderator (CrohnieToo) : 11/26/2009 6:47:33 PM (GMT-7)


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20576
   Posted 11/26/2009 12:23 PM (GMT -7)   
That sounds pretty good...thanks for posting it!

:)

CrohnieToo
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Date Joined May 2003
Total Posts : 9448
   Posted 11/26/2009 6:59 PM (GMT -7)   
*sigh* What I so dislike about these clinical trials is comparing them w/placebos instead of a similar drug and the use of the CDAI instead of a CTE, colonoscopy, etc.

Before final approval by FDA I'd like to see these drugs have to go thru a final clinical trial against a similar drug with results defined and confirmed by CTE or colonoscopy.

The hopeful thing about this drug tho is that it is oral, probably once a day, and is a new class of drug in that it targets a different inflammatory cause than any current drugs on the market.
Some people are like Slinkies... Not really good for anything, but they still bring a smile to your face when you push them down a flight of stairs.


GDen
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Date Joined May 2009
Total Posts : 703
   Posted 11/26/2009 7:24 PM (GMT -7)   
What's wrong with the CDAI? What's a CTE?

Rider Fan
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Date Joined May 2008
Total Posts : 1445
   Posted 11/26/2009 7:30 PM (GMT -7)   
Interesting. It doesn't seem to be a 'biologic' drug. This would be the first time I've ever heard of a CD-specific drug in development that isn't a biologic.
33 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. Proferrin iron pills.

Tried SCD, didn't work, now avoiding gluten and dairy.


Go Saskatchewan Roughriders!


BeeSting
Regular Member


Date Joined Nov 2008
Total Posts : 392
   Posted 11/27/2009 4:11 PM (GMT -7)   
Is it an immune suppressor? /Bee
 
Oh, and thanks a lot for letting us know...:)

CrohnieToo
Veteran Member


Date Joined May 2003
Total Posts : 9448
   Posted 11/28/2009 12:55 PM (GMT -7)   
You can have quite severe Crohn's even but if your symptoms aren't "classic" you won't even register on the CDAI or you will register as too mild. The CDAI is scored simply on how you feel and how you rate your symptoms and disregards some Crohn's symptoms entirely.

CTE = Cat Scan Enterography = pretty much an easier, more revealing small bowel follow thru. They use CT scans instead of conventional xray and a lighter form of barium that moves thru faster and isn't as inclined to cause constipation problems if you don't drink enough fluids after, etc.
Some people are like Slinkies... Not really good for anything, but they still bring a smile to your face when you push them down a flight of stairs.


GDen
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Date Joined May 2009
Total Posts : 703
   Posted 11/28/2009 4:57 PM (GMT -7)   
Ah... thanks! :)

73monte
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Date Joined Mar 2007
Total Posts : 1496
   Posted 11/28/2009 7:04 PM (GMT -7)   
Correct me if I'm wrong, but isn't the problem with CT Enterography as a diagnostic tool, a rather high exposure to radiation?
 
Tom.  
My daughter was diagnosed Feb. 19/07, (13 yrs. old at time of diagnosis), with Crohn's of the Terminal Illium. Has used Prednisone and Pentasa. Started Imuran (02/09), had an abdominal abscess (12/08). 2cm of Stricture.


Rider Fan
Veteran Member


Date Joined May 2008
Total Posts : 1445
   Posted 11/28/2009 7:37 PM (GMT -7)   
Yes, CT's do expose us to more radiation. The last time I had an imaging done my GI sent me for an MRI, which has less (none?) radiation.
33 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. Proferrin iron pills.

Tried SCD, didn't work, now avoiding gluten and dairy.


Go Saskatchewan Roughriders!


CrohnieToo
Veteran Member


Date Joined May 2003
Total Posts : 9448
   Posted 11/28/2009 8:47 PM (GMT -7)   
According to Mayo Clinic, Minnesota, gastroenterology department as of October 2008 MRE is promising but as of then was still not as effective as CTE for the small intestine.
 
MRE was only proving to be as effective or superior to CTE for the rectal area.
Some people are like Slinkies... Not really good for anything, but they still bring a smile to your face when you push them down a flight of stairs.


njmom
Veteran Member


Date Joined Apr 2006
Total Posts : 1884
   Posted 11/28/2009 8:50 PM (GMT -7)   
I was very skeptical when I saw the clinical results only in terms of CDAI.

CrohnieToo
Veteran Member


Date Joined May 2003
Total Posts : 9448
   Posted 11/29/2009 10:06 AM (GMT -7)   
The CDAI is usually the only test used for evaluation ot clinical trial results. The leading researchers all agree it is not perfect and should NOT be used by treating gastros to evaluate patients and their needs and that the CDAI's only value is in research. The other tests are just too expensive for routine use in clinical trials.
Some people are like Slinkies... Not really good for anything, but they still bring a smile to your face when you push them down a flight of stairs.

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