Azathioprine - Imuran - 6mp

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Aislin
Regular Member


Date Joined Feb 2004
Total Posts : 53
   Posted 11/28/2009 11:28 PM (GMT -7)   
Hi all,
 
I was just wondering if there are any huge differences between what a lot of you refer to as 6mp, and Imuran and Azathioprine? Why so many different names for what I am assuming are three quite similar things?
 
I have started Azathioprine, only been taking it just over a week. It has been making me feel awful. Saw my doctor who said it couldn't really be helped and would subside after a few months. Others who have been on this drug - if you had side effects how long did you experience them for before you got some relief?
 
Cheers

Female, mid-20's, lives in Australia
 
Symptoms since 99', Dx 2003, Right Hemicolectomy 2004, Trying to find the magic combination to manage this silly disease :)


80sChick
Veteran Member


Date Joined Oct 2009
Total Posts : 1054
   Posted 11/29/2009 5:41 AM (GMT -7)   
I may be wrong but I think Azathioprine is the generic term for Imuran. 6mp is a similar drug but they are not the same thing. I was on 6mp for a few years but it caused kidney stones, so I switched to Imuran. That worked fine for a few years, but then I switched GIs and my dr wanted me to try something else. In short, nothing else worked, and now I am back to trying Imuran. I don't remember the first time how long it took them to work (I think a few months), but right now I am on about month 2-3 and just keeping my fingers crossed.

What do you mean by "its been making you feel awful"? I don't know if I've ever felt AWFUL from any of these drugs (minus the kidney stones...that was pretty awful!), and I don't really know if these side effects will go away. I am not a dr though, so...? I am interested to hear others' thoughts on that.
28 Year old Female
Diagnosed with Crohn's Colitis March 2000
Recent possible diagnosis of IBS-D
 
Tried Meds: Asacol, Remicade, 6mp, Humira, Xifaxan, Apriso, Rowasa Enemas.
 
Currently on: 40mg Prednisone, 100mg Imuran, Align, Prenatal Vitamin, Vitamin B 12 Complex, Vitamin D/Calcium, Flomax (for urinary retention). 


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 11/29/2009 8:06 AM (GMT -7)   
Imuran and Azathioprine are the same thing. Imuran and 6mp are basically the same med they just are processed differently in your body. I tried Imuran but it made me really nauseous. Some said to make sure you take it with dinner and that is supposed to help with the side effects. I ended up switching to 6mp and taking it at bedtime and had no problems with it at all except some hair shedding. Hope that helps.
Gail*Nanners* Co-Moderator for Crohns Disease and Anxiety/Panic Forum
Crohn's Disease for over 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium  w/Vit D, and Xanax as needed. Resections in 2002 and 2005. Also diagnosed with Fibromyalgia, Osteoarthritis, and Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
It's scary when you start making the same noises As your coffee maker.
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Former58D
Regular Member


Date Joined May 2009
Total Posts : 173
   Posted 11/29/2009 12:00 PM (GMT -7)   
Drug name - Brand Name

Azathioprine - Imuran
Purinethon - 6MP

Azathioprine is a pro-drug: it is converted into 6MP once metabolized.
"What can't be changed must be endured" - unknown

DX with distal Crohn's colitis Oct 2007, predominantly in rectum
Colozal (750mg): 3 pills 3xdaily
Cortifoam - 1 nightly
6MP - currently at 100mg and waiting for response......


NostraHistoria
Regular Member


Date Joined Nov 2008
Total Posts : 351
   Posted 11/29/2009 1:51 PM (GMT -7)   
Imura (Azathioprine) gave me the chills and severe fatigue/sleepiness. I am off. Thank goodness. My new GI switched me to Humira. It actually works.
27m - Dx January 2005: UC/Crohn's
Humira, Entocort 9 mg, Asacol 4 x 3, Flagyl 250 mg x 3
Imuran failed


Rider Fan
Veteran Member


Date Joined May 2008
Total Posts : 1445
   Posted 11/29/2009 2:59 PM (GMT -7)   
Former58D said...
Drug name - Brand Name

Azathioprine - Imuran
Purinethon - 6MP

Azathioprine is a pro-drug: it is converted into 6MP once metabolized.


Actually, the drug name is 6-Mercaptopurine and the brand name is Purinethol.
33 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. Proferrin iron pills.

Tried SCD, didn't work, now avoiding gluten and dairy.


Go Saskatchewan Roughriders!


Former58D
Regular Member


Date Joined May 2009
Total Posts : 173
   Posted 11/29/2009 3:32 PM (GMT -7)   
Correct, I didn't read it before pressing submit.
"What can't be changed must be endured" - unknown

DX with distal Crohn's colitis Oct 2007, predominantly in rectum
Colozal (750mg): 3 pills 3xdaily
Cortifoam - 1 nightly
6MP - currently at 100mg and waiting for response......


pillpopper
Regular Member


Date Joined Jan 2009
Total Posts : 209
   Posted 11/29/2009 3:49 PM (GMT -7)   
I had the same horrible side effects with Imuran. smhair
Thank goodness for 6mp. :-)
B-12injections,Pentasa,Loperamide,Entocort,6mp,Hydrochlorothiazide,8 week
Remicade,vitamin-D,Fluconazole.More over the counter vitamin-D. Remission since surgery and 5-years, of 8-week Remicade.
.


Former58D
Regular Member


Date Joined May 2009
Total Posts : 173
   Posted 11/29/2009 7:55 PM (GMT -7)   
Imuran has more inert ingredients which can sometimes irritate folks. 6MP is the "purer" delivery form. My GI much prefers 6MP to Imuran, but some people who have issues with one can be successfully re-challenged with the other.
"What can't be changed must be endured" - unknown

DX with distal Crohn's colitis Oct 2007, predominantly in rectum
Colozal (750mg): 3 pills 3xdaily
Cortifoam - 1 nightly
6MP - currently at 100mg and waiting for response......


flowery
Regular Member


Date Joined Jul 2008
Total Posts : 440
   Posted 11/29/2009 10:38 PM (GMT -7)   
I had side effects when first starting the Imuran. Gasy, Bloated and grumpy and some chills. G.I. Dr. said to stick with it. It took about 4 months for the symptoms subside.
 Been on it now for 4 years! Still kinda freaks me out that at first I had so many side effects. Oh well, have to take something, I guess.
I have to get liver counts checked every 3 months. Good luck!
Flowery
 "Get busy living or get busy dying"
               
                         


Aislin
Regular Member


Date Joined Feb 2004
Total Posts : 53
   Posted 12/1/2009 4:01 AM (GMT -7)   
Wow - thank you all so much for your replies. I don't know what I would do without this forum. There is such a wealth of information, and to be able to hear other people's experiences it just helps so much.

Is 6mp something that is common is Australia? Because all I really hear about is the Azathioprine and Imuran. I have only started on 50mg of Azathioprine a day, with the end goal being 150mg a day. I have been having day-long nausea, migraines, leg cramps and aches, and terrible D. My gp said the nausea should go away after a few months, but my god it has been unrelenting :( I am supposed to take it in the morning so I take it with or shortly after my breakfast. But it still makes me feel sick.

I have had the migraines for ages anyway, but my gp wasn't sure if the leg cramps and D was from the Azathioprine or just the Crohn's. I am not due to have a blood test to check the effect of the Azathioprine until just before Chrissy, so will see what happens.

Tis bad enough being sick, but having medicine that makes you sick too just sux lol

Have not really heard much about Humira - what does that do? I know Remicade as in Infliximab. And a lot of people say they take Pentasa, what does that do?

Thanks again for all your replies, you guys are awesome.
Female, mid-20's, lives in Australia
 
Symptoms since 99', Dx 2003, Right Hemicolectomy 2004, Trying to find the magic combination to manage this silly disease :)


MoobyDoo
Regular Member


Date Joined Sep 2009
Total Posts : 212
   Posted 12/12/2009 10:12 AM (GMT -7)   
confused an anyone share any information about the risk of cancer from taking 6MP? Our doc mentioned recently that even short term use increases your chances of developing cancer over your lifetime. Makes me very nervous. Thanks.confused

  • Rider Fan
    Veteran Member


    Date Joined May 2008
    Total Posts : 1445
       Posted 12/12/2009 11:16 AM (GMT -7)   
    I would ask your doctor for some perspective. For instance, does it increase by 10%? 50%? .00001%?
    33 y/o male. Dx'ed in 1999. No surgeries.

    Current meds: Humira 2/27/09. Proferrin iron pills.

    Tried SCD, didn't work, now avoiding gluten and dairy.


    Go Saskatchewan Roughriders!


    AKTeach
    Regular Member


    Date Joined Sep 2005
    Total Posts : 83
       Posted 12/12/2009 11:29 AM (GMT -7)   
    I developed chronic pancreatitis years ago and the only thing my GI could link it to was the azathioprine I had taken for several months.  I now list the drug as one I have reaction to and will not take it again for that reason.
    My case may be quite unusual, but I hope this helps!!
    New Topic Post Reply Printable Version
    Forum Information
    Currently it is Friday, December 09, 2016 10:36 AM (GMT -7)
    There are a total of 2,735,394 posts in 301,299 threads.
    View Active Threads


    Who's Online
    This forum has 151402 registered members. Please welcome our newest member, Len.
    309 Guest(s), 11 Registered Member(s) are currently online.  Details
    robotguy, fly with me, smlafleur, iho, maria2016, rockyfords, InTheShop, sam12, JackH, Kristvet86, ljimd


    Follow HealingWell.com on Facebook  Follow HealingWell.com on Twitter  Follow HealingWell.com on Pinterest
    Advertisement
    Advertisement

    ©1996-2016 HealingWell.com LLC  All rights reserved.

    Advertise | Privacy Policy & Disclaimer