6MP and reproduction

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meshuganeh
Regular Member


Date Joined Sep 2003
Total Posts : 42
   Posted Today 4:28 PM (GMT -7)   
Any thoughts about/opinions/experience out there with having kids while on 6MP?
 
I am a 30 yo male that has been on 6MP for about 6 years.  In the next few years my wife and I are planning on having children.  I have been reading about the potential for birth defects due to 6MP.  I spoke to my internist about this and he said he has had patients with CD who have stayed on the 6MP and others who have stopped while trying to get pregnant.  He related a story of a man who stopped the 6MP and was essentially in a flare for 6 months as he and his wife waited for it to get out of his system, conceive, then get back on the 6MP and ramp it up to where it was working again.  This guy's GI doc was not happy that he went off the 6MP (but the internist was telling me the story to relate the fact that he would support whatever route I chose). 
 
Would love to hear from anyone with experience with this stuff.

Rider Fan
Veteran Member


Date Joined May 2008
Total Posts : 1445
   Posted Today 6:41 PM (GMT -7)   
I was in the same position as you 2 years ago. The data on men and 6MP is very confusing and contradictory. Most people don't realize that while conceiving on 6MP is considered perfectly safe for women, it's less clear for men.

To abbreviate a very long story, here is my timeline.

Sept 2007 - Want to have a baby! GI says it's probably fine to stay on 6MP. Says the study showing birth defects with men taking 6MP was small and poorly designed. I decide to take no chances and stop 6MP anyway. Been doing great on 6MP for years.

April 2008 - Conception taking longer than I thought. Not feeling well - tired, lost a few pounds, anemic. Go to GI and decide to get back on 6MP and continue trying to conceive.

May 2008 - Major bleed. Require blood transfusion, lose more weight.

September 2008 - Conception, baby due in June. Commence obsessive worrying about conceiving on 6MP, oh my God what have I done!

October 2008 - Still not feeling too well and 6MP should be working by now. Lets try methotrexate.

November 2008 - Major bleed. Require blood transfusion.

February 2009 - Require blood transfusion. GI says to decide between Humira and surgery! Hello Humira.

March 2009 - Major bleed. Require blood transfusion (#4 for those keeping score).

June 2009 - Cutest baby in the history of mankind is born. No abnormalities. Feeling better, Humira seems to be working. Able to get off of prednisone finally from last November.

Today - Gained weight back, energy level good. All in all doing well right now but I wish I didn't stop the 6MP in the first place. 5 month old baby is doing absolutely amazing.

Hope that helps. Good luck whatever you decide.

Mike
33 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. Proferrin iron pills.

Tried SCD, didn't work, now avoiding gluten and dairy.


Go Saskatchewan Roughriders!

Post Edited (Rider Fan) : 12/11/2009 6:44:51 PM (GMT-7)


meshuganeh
Regular Member


Date Joined Sep 2003
Total Posts : 42
   Posted Today 9:07 PM (GMT -7)   
Mike,

Thank you so much! Wow, what a story. I have to say it worries me a little. Did anyone give you any insight as to why the 6MP didn't work as it had in the past when you tried to restart it?

Congrats on having a healthy, beautiful child!

Rider Fan
Veteran Member


Date Joined May 2008
Total Posts : 1445
   Posted Today 9:48 PM (GMT -7)   
No problem and thanks.

Well, I think it's easier to KEEP remission that it is to ATTAIN in the first place. So, once I stopped the 6MP and flared up, it wasn't strong enough to get me back in to remission even though it did help somewhat, just not quite enough.

I do think I will get back on to 6MP at some point, but I'm going to stick with Humira for now. Plus, hopefully this will give my liver a break from the 6MP. And at least I found out that 6MP works better for me than the MTX did.

I really wish there were better studies on 6MP and contraception as it relates to men. It was an agonizing choice for my wife and I on what to do medication-wise.
33 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. Proferrin iron pills.

Tried SCD, didn't work, now avoiding gluten and dairy.


Go Saskatchewan Roughriders!


MoobyDoo
Regular Member


Date Joined Sep 2009
Total Posts : 212
   Posted 12/12/2009 7:20 AM (GMT -7)   

Hi guys.  Have been researching 6MP a bit myself lately. My child's doc may put her on it due to the fact that we haven't really been successful at getting her into full remission yet. The concerns he (and I) are having are in regard to the increase risk of cancer as a side effect.  Do you have any info about that? Scares the life outta me to think about putting my 9 yr old on something that may lead to cancer.

I did just read the following on a site I found, regarding reproduction. Hope its helpful:

"Bone marrow toxicity may occur but is not common at the usual dose. We recommend having a blood test (CBC) drawn weekly for the first three weeks and then monthly while on the drug. Our office will call you or mail a reminder to you when these tests are due. If marrow toxicity occurs, you may become anemic, develop bleeding problems, or a low white blood cell count. This could predispose you to serious infections. If you develop fever, a cold, or any infection while taking the drug, stop the 6-MP immediately and contact our office. We may resume the drug when the infection has cleared. Headaches and nausea are the most common side effects we have observed. If intolerable, they require stopping 6-MP. Pancreatitis occurs in a very small number of patients. This may be a very serious illness. Symptoms include severe abdominal pain and vomiting. Hospitalization could be required. Increased cancer risk is at least a theoretical risk of 6-MP, but large series of patients have not shown any measurable increase in the occurrence of cancer. Teratogenicity, or damage to an unborn child, is a possible risk of 6-MP. Women should be using an effective method of contraception (birth control) while on 6-MP. If a woman wishes to become pregnant, we feel she should be off 6-MP for at least 3 months before attempting to conceive. This is good advice for a prospective father as well."

 



  • Nanners
    Elite Member


    Date Joined Apr 2005
    Total Posts : 14995
       Posted 12/12/2009 9:17 AM (GMT -7)   
    Many women on this very forum have had healthy babies while still on meds such as 6mp, Imuran, Remicade, Humira and Pred. The only med I know that these women should not use while pregnant is Methotrexate. I am hoping Stef17 will be along. She will be able to provide some very good links about these meds and conception. Good luck!
    Gail*Nanners* Co-Moderator for Crohns Disease & Anxiety/Panic
    Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
    *Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

    Rider Fan
    Veteran Member


    Date Joined May 2008
    Total Posts : 1445
       Posted 12/12/2009 11:14 AM (GMT -7)   
    Nanners in correct. Studies have shown that there is a greater risk to a fetus when the mother stops 6MP and puts herself at risk for a flare than from the 6MP itself.


    "If a woman wishes to become pregnant, we feel she should be off 6-MP for at least 3 months before attempting to conceive."

    Well, obviously it's better to be on NO medication but that's not always possible. Conveniently they make no mention of how to keep the mother in remission during pregnancy. Minor detail there! That part of the article sounds like it was written by a lawyer rather than a doctor if you get my drift.
    33 y/o male. Dx'ed in 1999. No surgeries.

    Current meds: Humira 2/27/09. Proferrin iron pills.

    Tried SCD, didn't work, now avoiding gluten and dairy.


    Go Saskatchewan Roughriders!


    cdteacher
    Regular Member


    Date Joined Jul 2005
    Total Posts : 48
       Posted 12/12/2009 3:55 PM (GMT -7)   
    I have been on 6mp for 6 1/2 years. In that time I have had 2 successful births/deliveries and am pregnant with my third baby now.  My kids are beautiful, happy, and healthy. I had no problems at all including getting pregnant (1st try all three times). 
    Diagnosed with Crohn's in '03 by trip to ER followed by surgery and 11 days in the hospital.


    MoobyDoo
    Regular Member


    Date Joined Sep 2009
    Total Posts : 212
       Posted 12/13/2009 5:56 AM (GMT -7)   
    Good to know all. Thanks for the info.

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