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Keeper
Veteran Member


Date Joined Jun 2008
Total Posts : 1058
   Posted 12/17/2009 12:06 AM (GMT -7)   
Low-Dose Naltrexone Therapy Improves ActiveCrohn’sDisease:

http://www.fertilitycare.net/documents/LowDoseNaltrexoneTherapyImprovesActiveCrohnsDiseaseAmericanJournalofGastroenterology2007.pdf

Same paper in an abstract from Nature:

http://www.nature.com/ajg/journal/v102/n4/full/ajg2007152a.html

The Opioid Antagonist Naltrexone Improves Murine Inflammatory Bowel Disease (mouse study):

http://informahealthcare.com/doi/abs/10.1080/15476910802131469

njmom
Veteran Member


Date Joined Apr 2006
Total Posts : 1884
   Posted 12/17/2009 3:13 PM (GMT -7)   
Thanks...I had not seen the mouse study. It sounds like it was for colitis, not Crohn's?
Daughter (22) Dx'd Crohn's 3/06. Misdiagnosed for two years, including by top pediatric Crohn's specialist as stress. No symptoms for the past two years. Recent colonoscopy shows stricture gone but still two spots of inflammation in TI. Used LDN to taper off Entocort. Was on Entocort since April 06. Never had D. 4.5 mg LDN, SCD multivit, homemade yogurt, 5000IU vit D3, 500 mg calcium, 27 mg iron, monthly B12 shots, daily oral B12 1000. SCD diet modified to include potatoes and rice. 


Keeper
Veteran Member


Date Joined Jun 2008
Total Posts : 1058
   Posted 12/17/2009 10:42 PM (GMT -7)   
They have to try to duplicate the conditions of Crohn's in mice and generally they just cause inflammation and run their tests on the inflamed mouse gut. It's not a very exact model, but it does show things about gut inflammation. I don't think that they have duplicated Crohn's in mice exactly.
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