Prednisone vs Prednisolone?

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Veteran Member

Date Joined May 2009
Total Posts : 703
   Posted 1/2/2010 2:24 AM (GMT -6)   
Anybody know the difference between these two steroids? I don't think I've heard of any CD patients being prescribed prednisolone, rather prednisone. I think I read that prednisone is actually converted into prednisolone by the liver, which then works on the body. Prednisolone also appears to be available in oral form (liquid or tablet), so I guess it's not a question of getting past the stomach. It also appears to be more expensive, so maybe it's not generic yet.
Cimzia, Asacol

Regular Member

Date Joined Dec 2007
Total Posts : 414
   Posted 1/2/2010 6:47 AM (GMT -6)   
Whenever I've had steroids in the past its always been prednisolone but this is the UK, they were little red tablets. Never really worked for me and also gave me horrific side-effects which got worse with every course - the last course I had my doctors were became really concerned for my mental health and have said I am never to go on them again. I wonder how different the two are? Like if prednisone might be more suitable than prednisolone in terms of effectiveness and side-effects or whatever?

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 1/2/2010 10:34 AM (GMT -6)   
I always thought they were the same. I thought maybe Prednisolone was a UK or Australian product, but the samething with a different name than Prednisone.
Gail*Nanners* Co-Moderator for Crohns Disease & Anxiety/Panic
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
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Veteran Member

Date Joined Jan 2007
Total Posts : 3200
   Posted 1/2/2010 1:09 PM (GMT -6)   
I'm pretty sure you're right Gail...

Too many years with CD
Two bowel resections, several obstructions.
Fibromyalgia and recently diagnosed with chronic pancreatitis and lupus.
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Elite Member

Date Joined Feb 2004
Total Posts : 20558
   Posted 1/2/2010 2:10 PM (GMT -6)   
From my understanding of it (I could be wrong), prednisone is only administered orally (via pill form) prednisolon can be administered topically, orally or injected (liquid form or pill form) and is a touch stonger than prednisone but in essence has the same effect.

The main difference is that prednisone is activated by the liver into prednisolone.

Here's a link...

bee propolis caps 500mg one cap twice/day
omegas 369 caps one cap twice/day
probiotics 10 billion cfu once/day
vitamins C-calcium ascorbate (easy on the gut) and vitamin A each once/day
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I've also altered my diet (no junky stuff at all, processed, fast-foods, refined sugars, ect) and exercise regularly.
I went from 30+ bloody BM's/day with lots of lower back pain to an average of 5/day no bleeding no back pain and completely formed stools, still have severe urgency issues.
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Veteran Member

Date Joined May 2009
Total Posts : 703
   Posted 1/2/2010 2:47 PM (GMT -6)   
Yeah, back when I had a minor (but very painful) eye ulcer they gave me prednisolone drops. I guess prednisone drops wouldn't do anything since it needs to go through the liver. They worked very quickly, just like prednisone.
Cimzia, Asacol

Veteran Member

Date Joined Aug 2007
Total Posts : 1202
   Posted 1/2/2010 5:50 PM (GMT -6)   
I don't know the difference, but I do know I am allergic (hives everywhere) to prednisone, but I can take methylprednisolone...
1 fistula, crohn's colitis, limited to large intestine
Compounded budesonide 3mg/daily, Started Cimzia first dose 2/10/09. Dx Osteoporosis 10/08 started Forteo 1/27/09

Regular Member

Date Joined Apr 2009
Total Posts : 382
   Posted 1/2/2010 9:40 PM (GMT -6)   
Equivalent Glucocorticoid Potency (mg) Mineralo-corticoid Potency Plasma Half-Life (min) Duration of Action (h)
Hydrocortisone (Cortisol) 20 0.8 90 8–12
Cortisone 25 1 30 8–12
Prednisone 5 0.25 60 24–36
Prednisolone 5 0.25 200 24–36
Methylprednisolone 4 0 180 24–36
Triamcinolone 4 0 300 24–36
Dexamethasone 0.75 0 200 36–54

Veteran Member

Date Joined Dec 2005
Total Posts : 637
   Posted 1/3/2010 6:34 PM (GMT -6)   
Adding solu-medrol to jp's list, I have only received it in the hospital via an iv though.
Humira 2 x month, Lialda 2 x day, Imuran 100mg x day, Remeron 30mg x day, Pain Meds, Zantac 300mg 2 x day, Prednisone 2.5mg x Every third day(01_02_10), Vitamins = B12 Injection(Once x Week), Magnesium, Calcium, Multi-Vitamin, Potassium, Folic Acid. (Phenergen 25mg Per Request Needed). -- FaceBook

Regular Member

Date Joined Jan 2010
Total Posts : 222
   Posted 1/8/2010 1:14 AM (GMT -6)   
I thought they were the same....depending on what country you are in to what they are called...... could be wrong.....
Michelle Ashworth 40 years old
Diagnosed with CD 2004 (undiagnosed correctly +- 3 years, wrongly diagnosed with IBS)
Bowel resection 2005
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