Methotrexate when nothing else works?

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debilitated
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Date Joined Jan 2010
Total Posts : 448
   Posted 1/4/2010 10:38 PM (GMT -7)   
Hello All. I have been lurking around for awile and felt the need to drop in.

I was curious to know if anyone else has found Methotrexate to be affective even though other traditional therapies have not worked. Such as: All Oral Medications and All 3 TNF's.
The Only medications I have not been on are Tysabri and MTX.

Thanks in Advance!

debilitated
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Date Joined Jan 2010
Total Posts : 448
   Posted 1/4/2010 10:59 PM (GMT -7)   
And Why does MTX have such a BIG BLACK BOX warning? it says to only use in severe neoplastic diseases or severe debilitating arthiritis or psoriasis?

This Drug is scary?

Wolfie40
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Date Joined Dec 2008
Total Posts : 947
   Posted 1/5/2010 5:10 AM (GMT -7)   
Look at Humira and remicade, they are very scary too. Look at the scrolling box to the right about Humira.
People here that have been taking Metho are not having many issues with it so far. I'm sure someon will be along soon to help you with your fears about Metho.


Sometimes you just gotta do what you gotta do!!
Diagnosed with Crohns in 2001
First and hopefully last Ileocecectomy 2/18/2009

Medications:Humira,  Asacol, FolicAcid,  Multivitamin, 1000mg Calcium, Vitamin D, Probiotics, Pepcid Complete, Questran,  Monthly B-12 injections.

Living a Great life with my Wife and my two Chocolate Labs
Hunter & Hailey.
I love them dearly.


Nanners
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Date Joined Apr 2005
Total Posts : 14995
   Posted 1/5/2010 7:54 AM (GMT -7)   
We have a few members here who are on Methotrexate. One good thing about it is it works not only for the Crohns but helps the joints too. Good luck!
Gail*Nanners* Co-Moderator for Crohns Disease & Anxiety/Panic
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Bammer
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Date Joined Mar 2008
Total Posts : 381
   Posted 1/5/2010 11:00 AM (GMT -7)   

I have been on Methotrexate for 16 months with no side effects so far. Getting bloodwork done every two months now.  I think taking a high dose for cancer would be different than the dose that would be prescribed for Crohn's? Cannot comment on any other medications but they all are scary and they all carry warnings.

I did have a resection for a stricture that was undetected probably for many years, found to be scar tissue and the MTX had shown some improvement but wasn't going to make it go away.

As I have never had the symptoms of pain, diarrhea or bleeding, the real indicator will be when I have my next tests, ultrasound in April and colonoscopy some time after that.


57 yr. old F dx. CD 07/07
Was on prednisone for three months but no medication for next 11 months.
Started weekly methotrexate injections 09/22/08.
Lap assisted sigmoidoscopy done May 11/2009


debilitated
Regular Member


Date Joined Jan 2010
Total Posts : 448
   Posted 1/5/2010 11:10 AM (GMT -7)   
Bammer or anyone else.. I appreciate that answer... Everyone is different yes.. I really just need a drug to work for me. I am running out of options.

Im going to ask about it definitly. I get leukepenic from 6-mp. I hope i dont from mtx

bella3250
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Date Joined Aug 2008
Total Posts : 351
   Posted 1/5/2010 10:13 PM (GMT -7)   
Hi debilitated.  I'm so sorry for what you're going through and unfortunately I know exactly how you feel.  I too have tried every drug out there except metho and tysabri.  Not for nothing but not even my gi doc will give me the tysabri.  He says there have been reports of a lot of brain infections and death.  Not for me, I'll pass.  I also get sick on 6mp.  Last time I was on it my white blood cell count went through the roof and scared the crap out of my gi and hemotologist.  I wasn't even on a therapudic dose either.  Anyway right now I am on Cimzia and failing it miserably.  Doc wants to put me on the metho.  Scared crapless of it.  Don't know what else to do though.  Husband and mother don't want me on it.  Who do I make happy first.  Husband, mother, or myself?  I see a lot of people on here on it and most of them have very positive things to say about it.  Don't know though.  Worried about my liver.  I have an innate ability to have reactions to medications that nobody or very few people have.  My crohn's has also spread to the right side of my mouth and cheek.  Just inflammation in the tissue.  Very swollen and looks like I have a fat lip.  I also have the strangest side effect from the crohn's as I just mentioned.  Hope this helped a little bit.  Good luck to you and me.  wink

Bammer
Regular Member


Date Joined Mar 2008
Total Posts : 381
   Posted 1/5/2010 11:33 PM (GMT -7)   

Bella, I can see not wanting to take Methotrexate if you are wanting to get pregnant but I thought the idea of having bloodwork done was to check and stop using it before any damage would be done?  Don't know what your immediate reaction might be?

Believe me it was not an easy decision as I do not have any usual symptoms of Crohn's but Remicade and even Imuran scared me more. So each person has their own perception and willingness to take different risks.

Hope you all find something that works for you.


57 yr. old F dx. CD 07/07
Was on prednisone for three months but no medication for next 11 months.
Started weekly methotrexate injections 09/22/08.
Lap assisted sigmoidoscopy done May 11/2009


Wolfie40
Veteran Member


Date Joined Dec 2008
Total Posts : 947
   Posted 1/6/2010 5:12 AM (GMT -7)   
I did not want to take Metho,Imuran, 6mp, Remicade or Humira because of all the side effects but when my GI told me that my Crohns was back after a short lived remission from surgery, I figured I better listen to my GI and hit this thing hard.
Am I concerned about the side effects? Yes! But I'm more concerned about Crohns doing excessive damage and having to have surgery again. Remeber surgery isn't a cure!!!
Good luck with your decision.
Diagnosed with Crohns in 2001
First and hopefully last Ileocecectomy 2/18/2009

Medications:Humira,  Asacol, FolicAcid,  Multivitamin, 1000mg Calcium, Vitamin D, Probiotics, Pepcid Complete, Questran,  Monthly B-12 injections.

Living a Great life with my Wife and my two Chocolate Labs
Hunter & Hailey.
I love them dearly.


asc58
Regular Member


Date Joined Jun 2006
Total Posts : 83
   Posted 1/6/2010 7:36 AM (GMT -7)   
We could not find any meds that would work for me. I've been through them all over the past 35 yrs.  My doc put me on Metho. injections and it seems to working fine for me. The only thing is I get real tired for about 24 hours after my injection but it passes and I feel good the rest of the week. Yeah!
 
As far as worry about the meds side effect... I'm lucky to have found a Dr. who has worked with all these drugs and knows how to use them. I trust him with my life (as we all do with our doctors)  100 percent and he watches over me like a hawk!  So follow your gut feelings ( no pun intented) and if you don't have complete confidence in your GI, keep searching until you find one. It can take some time.  Good luck to you.
 
Steve
Crohn's in the ileum for the last 35 yrs.  3 ressections, numerous attempts at fistulae repairs, a battle with C Diff (that was bad), while recouping from C Diff, I had two PE's. Doing good now.
RX: Methotrexate, Zoloft.
 
 


debilitated
Regular Member


Date Joined Jan 2010
Total Posts : 448
   Posted 1/6/2010 8:26 AM (GMT -7)   
wow, well thanks for all the comments.

6-mp makes me luekepenic. Will MTX do this also?

MMMNAVY
Veteran Member


Date Joined Jul 2006
Total Posts : 6927
   Posted 1/6/2010 8:33 AM (GMT -7)   
Injectable MTX is the only thing that has even remotely worked for me (3 years and counting). It really depends on the luekepenic issues, but I would definately make sure you are getting your blood work done on a regular basis.
Forum Co-moderator - Crohn's Disease/Thyroid Disorders:_All comments have the caveat contact your local health care provider.

I will find a way or make one. –Phillip Sidney 1554-1586

All that I am and all that I shall ever be, I owe to my Angel Mother.

The Bucket List- Have you found joy in your life?  Has your life brought joy to others?

Make sure your suffering has meaning…


debilitated
Regular Member


Date Joined Jan 2010
Total Posts : 448
   Posted 1/6/2010 11:34 AM (GMT -7)   
Thanks MMMNAVY, what are some things you notice? any liver damage or vomiting from the metho?

lilcrohnieUK
Regular Member


Date Joined Dec 2007
Total Posts : 414
   Posted 1/6/2010 11:43 AM (GMT -7)   
This is my 8th year on methotrexate, started out tablets now on injections. My liver and kidney function has remained perfect throughout the whole time I've been on it. There was one time they suspected neutropenia but it turned out to be nasty virus instead. I've had remission periods of up to 3 years while on it, love the drug! Makes me a bit tired the day after but nothing I can't handle.
 
 


debilitated
Regular Member


Date Joined Jan 2010
Total Posts : 448
   Posted 1/6/2010 12:11 PM (GMT -7)   
Because you all responded and since I have been on TPN for 3 months in the past... I feel maybe I shouldn't worry about liver and kidney problems. I seem to Handle most meds. Thanks all. Those answers Really Helped my decision.

debilitated
Regular Member


Date Joined Jan 2010
Total Posts : 448
   Posted 1/6/2010 12:12 PM (GMT -7)   
1 other thing.... Something i should really ask my doc.. but hey ill attempt to.
I seem to to metabolize injections so fast... Remicade, humira and cimzia..

you think the oral way may be better at first?

Bammer
Regular Member


Date Joined Mar 2008
Total Posts : 381
   Posted 1/6/2010 12:13 PM (GMT -7)   

My GI prescribed some very expensive anti-nausea medication (Ondanstron) when I first started with MTX injections but only took them as a precaution with the first injection. No problem then and none since.

No side effects to date.


57 yr. old F dx. CD 07/07
Was on prednisone for three months but no medication for next 11 months.
Started weekly methotrexate injections 09/22/08.
Lap assisted sigmoidoscopy done May 11/2009


ZenaWP
Veteran Member


Date Joined Aug 2007
Total Posts : 884
   Posted 1/6/2010 12:40 PM (GMT -7)   
My arthritis has been flaring for a year now and nothing has gotten it under control.  The injectable methotrexate was working SO much better than anything else, but it raised my liver enzymes and I had to stop it.  We even tried again at a lower dose a little later, but it didn't help as much at the lower dose and it raised my enzymes again, so I am off of permanently.  I was extremely disappointed when I had to stop it.  With the mtx pills, I had stomach pains, but the shots didn't cause me any side effects except for the elevated liver enzymes.

Crohn's Disease, Acid Reflux/Gastritis, Hashimoto's Thyroiditis, Endometriosis, Arthritis, Depression/Anxiety.  Too many meds to list them all.  =) 


asc58
Regular Member


Date Joined Jun 2006
Total Posts : 83
   Posted 1/6/2010 5:21 PM (GMT -7)   
With Crohn's disease you will want to go with injections.

Steve
Crohn's in the ileum for the last 35 yrs.  3 ressections, numerous attempts at fistulae repairs, a battle with C Diff (that was bad), while recouping from C Diff, I had two PE's. Doing good now.
RX: Methotrexate, Zoloft.
 
 


Howlyncat
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Date Joined Jan 2005
Total Posts : 24909
   Posted 1/6/2010 5:43 PM (GMT -7)   
I have been on mtx for quite some time and my doc also rx s folic acid with it,,lyn


                          
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Post Edited (Howlyncat) : 1/6/2010 6:43:02 PM (GMT-7)


lilcrohnieUK
Regular Member


Date Joined Dec 2007
Total Posts : 414
   Posted 1/7/2010 3:55 AM (GMT -7)   
There isn't a huge amount of difference between tablets and injections in terms of effectiveness. I was on the tablets for 7 years did great but then I either needed a more potent dose (the injections deliver more of the drug making equal doses stronger than tablets) or I was having malabsorption issues and went on to injections.

In the UK its rare for MTX to be given by injection, I had such a fight on my hands to be given the chance to try it! But I was certain as the MTX tablets had worked so well in the past it just needed a boost......I was right!
 
 


asc58
Regular Member


Date Joined Jun 2006
Total Posts : 83
   Posted 1/7/2010 4:29 AM (GMT -7)   
My Doc. was going to attempt to move me to MTX tablets but then reversed his discision based on studies suggesting that injections are more effective than tablets. I did not questioned it or ask for details because the injections were working just fine for me and I did not want to change over.  But, one thing (I) believe is certain is that injection is more Gut Friendly than the tablets by-passing some side effects on the digestive system that some people experience? That is strictly based on my opinion with no medical training or education to back it up! lol  Have a great day Everbody!
 
Steve
Crohn's in the ileum for the last 35 yrs.  3 ressections, numerous attempts at fistulae repairs, a battle with C Diff (that was bad), while recouping from C Diff, I had two PE's. Doing good now.
RX: Methotrexate, Zoloft.
 
 

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