Thanks all for your responses. An informed decision is the best one to make, but knowledge sure can be frightening. These are pretty difficult decisions we have to make. I used to spend a lot of time in the sun trying to get a tan, despite my very fair skin. That was way before sunscreen. I wear sunscreen everyday now, but the damage has already been done. Knowing the increased risk of skin cancer and with my history, it would seem foolish to take Imuran. Even with close monitoring and early treatment, a little teeny cancerous lesion on the surface of the skin seems to require a much larger area to be excised. I defended a lawsuit where the patient lost his entire nose to skin cancer. But it would also be foolish of me to not do anything about the ulcerations found at my anastomosis during my recent colonoscopy. So, here I go again - weigh the risks and benefits and choose the least offensive of all evils. SB
50 y/o F. CD dx'd Aug 05. Initially on Pentasa, then Imuran 125 mg. Started Humira (very reluctantly) on 10/24/07. Ileocolectomy 4/08. Back on Pentasa as maintenance.