MTX & Canker Sores

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Regular Member

Date Joined Aug 2008
Total Posts : 305
   Posted 1/15/2010 12:41 PM (GMT -6)   
I started Methotrexate about 4 months ago. recently and currently I have developed very painful canker sores in my mouth. Its almost impossible to eat or drink. Could this be from the Metho??
*added title to your post so it could get more responses*

Post Edited By Moderator (Nanners) : 1/15/2010 10:50:12 AM (GMT-7)

Rider Fan
Veteran Member

Date Joined May 2008
Total Posts : 1445
   Posted 1/15/2010 3:38 PM (GMT -6)   
Folic acid deficency perhaps?
33 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. Proferrin iron pills.

Tried SCD, didn't work, now avoiding gluten and dairy.

Go Saskatchewan Roughriders!

Regular Member

Date Joined Aug 2009
Total Posts : 377
   Posted 1/15/2010 4:18 PM (GMT -6)   
Yes, canker sores are one of the side effects of Methotrexate. You can even do a google search for it and a lot of hits will come up. My rhuematologist always asks me at every visit if I am experiencing mouth sores. I would call you prescribing doctor and let them know what you are experiencing.

(On a side note, when my Crohn's was diagnosed, I had really serious canker sores all over my mouth, so now I won't know if I get them again if it's the methotrexate or the Crohn's.)

Hop you get everything taken care of soon.

Veteran Member

Date Joined Sep 2009
Total Posts : 1176
   Posted 1/15/2010 4:29 PM (GMT -6)   
Just FYI, canker sores are also a primary symptom of celiac disease or gluten intolerance. If you stop eating gluten (wheat, barley, labels, soy sauce has wheat for example!) for a week or two and the sores go away, then they come back when you eat gluten again, you might want to talk to a gastroenterologist about being tested for celiac disease. Lots of people with Crohn's have celiac as well.
Autoimmune hepatitis, Hashimoto's thyroiditis, lupus, fibromyalgia, rheumatoid arthritis, celiac disease, asthma, psoriasis, Raynaud's syndrome, hypertension, osteopenia, sleep apnea, restless leg syndrome, GERD.

Latest Dxs: Lyme disease!! Lyme ELISA and Western Blot IgM/IgG Positive!
also degenerative disc disease. :(

Prednisone, Imuran, Plaquenil, Lyrica, Cymbalta, Darvon, Levothyroxine, Atenolol, Cozaar, Mirapex, Zyrtec, Fosamax, Albuterol, Prilosec, CPAP

Regular Member

Date Joined Jan 2010
Total Posts : 336
   Posted 1/15/2010 4:41 PM (GMT -6)   
When I first got sick with Crohn's, my mouth was a hot bed of canker sores!
Nothing helped except sucking on ice chips. My parents thought that 1 or 2 might have been explained away as a bruise from brushing my teeth, but the most I had in my mouth at 1 time was 9! And they were in places you can't reach like right above my tonsils. I told my GI about that and she said the words 'aphthous ulcers' and that Crohn's effects Mouth to Anus, so I definitely think that these sores are Crohn's related and not due to any side effects from a drug. Once you're in remission, they'll go away or at least go back to normal, as in 1 or 2 here or there throughout the year.
Diagnosed with typical Crohn's at 16.
Got lucky with Asacol for a year, then even luckier with ten years of relative remission.
Now abscesses and fistulas are having an "atypical" Crohn's party around my junk.
Remicade is coming to get me soon!

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