Should I ask for a second opinion?

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imissicecream
Regular Member


Date Joined Oct 2009
Total Posts : 157
   Posted 1/25/2010 5:33 PM (GMT -7)   
My doc wants to put me on humira, however, I've had two CT scans and a small bowel x-ray where no inflammation showed up, but my symptoms are still persisting. Do you think I should ask for another colonoscopy just to make sure these symptoms are really Cronh's before starting on this more serious drug?
Has anyone else had symptoms without having inflammation on the scans?
18 year old female
Crohn's dx in May 2009, symptoms since October 2008
Currently taking: Pentasa 1 gm/4x daily; Humira injections; Entocort 9mg


Former58D
Regular Member


Date Joined May 2009
Total Posts : 173
   Posted 1/25/2010 5:50 PM (GMT -7)   
My CT scan was normal too, but the colonoscopy was a different story. What did your C-scope show? If your C-scope was bad, then I would recommend going with the biologics. I'm on remicade now and doing much much better symptomatically than before. If your symptoms are somewhat bearable then maybe hold off while you get a second opinion.
"What can't be changed must be endured" - unknown

DX with distal Crohn's colitis Oct 2007, predominantly in rectum
Colozal (750mg): 3 pills 3xdaily
Cortifoam - 1 nightly
6MP - currently at 100mg and waiting for response......


imissicecream
Regular Member


Date Joined Oct 2009
Total Posts : 157
   Posted 1/25/2010 5:55 PM (GMT -7)   
The only scope that i've had was last May and the doc said that I had Crohn's but the case was VERY mild. He seemed very confused as to why I keep flaring like this, but didn't do any more testing other than blood work. I've been on azathioprine too...but that made me feel absolutely horrible...after a month of being on it I had the worst flare of my disease.
18 year old female
Crohn's dx in May 2009, symptoms since October 2008
Currently taking: Pentasa 1 gm/4x daily; Humira injections; Entocort 9mg


jeanneac
Veteran Member


Date Joined Feb 2009
Total Posts : 1812
   Posted 1/25/2010 6:03 PM (GMT -7)   
I've had the opposite situation where the CT scan shows more inflammation than the biopsy and scope. Recent biopsies were normal but the doc said my colon was still red and inflammed looking. I think we have to trust our symptoms because obviously these tests don't predict what is going on with 100% accuracy. I've been pretty sick lately too.
diagnosed 1/09 with "diverticular colitis" ?? location: sigmoid colon
localized scleroderma, IBS, asthma/allergies,
low thyroid,claritin, advair, singulair, diovan, progesterone, lialda, VSL#3 probiotic, Vit. D

Blood test positive for Crohn's via prometheus ibd serology panel


medchrt1
Veteran Member


Date Joined Sep 2005
Total Posts : 517
   Posted 1/25/2010 6:07 PM (GMT -7)   
TNF blockers such as humira and remicade developed for arthritis are targetting inflammation by blocking cytokines. In contrast, classic hormones, such as insulin, are secreted from discrete glands (e.g., the pancreas) see wikipedia on cytokines. Did your doctor sort this out? what I am suggesting is doing a week of zinc to see what happens as I do not know your symptoms. The action of cytokines may be autocrine or paracrine, but not endocrine. doesnt this mean that if your symptoms are pancreas related the humira may not be the correct approach. But it is worth a try if its paracrine.

Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 1/26/2010 9:28 AM (GMT -7)   
4. Use good judgement. NEVER rely on information or opinions exchanged via the forums or chat rooms to replace necessary, personal consultation(s) with qualified health or medical professionals to meet your individual health or medical needs. Remember that what's right or has worked for one person may not be what's right for you.


Gail*Nanners* Co-Moderator for Crohns Disease & Anxiety/Panic
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*
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