women on methotrexate

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Regular Member

Date Joined Aug 2009
Total Posts : 377
   Posted 2/4/2010 12:10 PM (GMT -6)   
Have any of you women on methotrexate experienced amenorrhea (loss of your period)? I'm starting to wonder if that's what's causing mine, but I can't find that much research on it.

Regular Member

Date Joined Jan 2010
Total Posts : 21
   Posted 2/4/2010 12:14 PM (GMT -6)   
Hi, I didnt experience that.  I hope you find out what's going on.
Best of luck to you.

Veteran Member

Date Joined Aug 2007
Total Posts : 884
   Posted 2/4/2010 1:11 PM (GMT -6)   
I lost mine when I was about 21 or 22, but I wasn't on mtx yet.  Never really figured out what caused it, but I am on depo now so I don't have them anyway. 

Crohn's Disease, Acid Reflux/Gastritis, Hashimoto's Thyroiditis, Endometriosis, Arthritis, Depression/Anxiety.  Too many meds to list them all.  =) 

Regular Member

Date Joined Oct 2007
Total Posts : 390
   Posted 2/4/2010 9:53 PM (GMT -6)   
I stopped getting my period the first time I got sick and didn't get it again for about 10 months.  I still don't know why it happened, but I had lost about 40 lbs and was 93 lbs at my absolute lowest in the hospital so kind of chalked it up to that.  It could have been from that, or all the medicine, or the Crohn's.  I asked all my doctors (my GI, my primary, my gynocologist, etc) and they all had the same answer of "if you're definitely not pregnant then just wait, if it doesn't come back we'll figure it out then, etc".  In my experience, my doctors don't communicate on any level so it's tough to get answers for stuff like this.  My GI dr wants my insides to stop being inflamed, my primary doesn't want me on prednisone since it is eroding my bones, etc, etc. 
My periods tend to stop when I have a flare (I have had about 4 of them now in the past 4 years) and they just come back when they do.  I used to be on b.c. but stopped since at that point nothing was being absored by my body and they would have stopped working anyway.  I did read something recently about how b.c. pills affect some people with Crohn's, kind of like smoking or dairy, etc but there isn't much research behind it.
Sorry I don't have an answer but I did go through the same thing!  I know it sucks. :(
32 yr old Female
Crohn's Colitis
DX 12/06
Currently on Remicade, trying to remember to take Multivitamin and Calcium, need to start taking Probiotics and Omega 3-6-9 and Vitamin D

Veteran Member

Date Joined May 2007
Total Posts : 1488
   Posted 2/4/2010 10:09 PM (GMT -6)   
BINGO! I'm so glad someone else picked up on this! I can't remember now, why, I had to come off my Imuran (same class of drug as methotrexate) for awhile some time ago. Within 3 days of coming off it my period was back with a vengenence! I absolutely hated those weeks too because my Crohns was always worse! My usual stent was sometimes 2-3 periods a month or none at all! I also could tell it was not only messing with my estrogen but FSH levels as well. Anyhow, all that is behind me I hope...haven't had a period in 6 months (WOOOHOO)! I believe I am post-menapausal now! Being underweight can cause you to stop having a period. Which is quite common in a flaring Crohn's patient with the ability to drop 20lbs in a week. Let your OB/GYN know immediately though...always better safe than sorry. Down side to menapause....I put on 15lbs in the first month I quit!!! I tell my husband it's my insurance layer!
Dx'd Jan'06, 1st Resection 7/06, Humira, Imuran, B12 injections, Nexium, Lexapro, Nulev, Glucosamine, Multi-Vitamin, Calcium Citrate, Ultracet. Secondary conditions: Psorasis, Osteoarthritis, Fibromyalgia, Lactose Intolerant, gallstones, kidney stones, Carpel Tunnel & POST-menopausal (Hurray)

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