Antibiotic-Induced Colitis?

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hld4good
Regular Member


Date Joined Jan 2010
Total Posts : 193
   Posted 2/6/2010 10:24 PM (GMT -7)   
My friend has been told her daughter has antibiotic-induced colitis. I searched all the medical sites, but I'm more interested in info from someone who had it and might know what to expect.
Age 58, Crohn's since age 21
3 bowel resections, 1980,88,95
1 fistula repair, 2005
probiotic
digestive enzymes
L-glutamine powder 3 times a day
sublingual B-12 and B complex
2 T. cod liver oil
2 tsp. tart cherry juice concentrate
Multiple vitamin, 2,500mg vit. C, 1,000mg calcium mag.


wednesday77
Regular Member


Date Joined Oct 2007
Total Posts : 390
   Posted 2/7/2010 7:55 AM (GMT -7)   
I am not sure what antibiotic-induced colitis is (aside from taking the literal meaning) but the first time i got really sick and was diagnosed with Crohn's Colitis there were a few factors that brought me to that point, one being a course of antibiotics I had been on for the dentist.  I also had been sick from whatever flu-bug was going around, so my dr told me that maybe the combo of the flu plus antiobiotics "flipped the switch" for my crohn's.  By the time I finally got to my GI I was a complete mess and had to be admitted to the hospital right after my colonoscopy.
I had had mild issues and symptoms for years before that but they were never a big deal (maybe a bit of b in the stool here and there, D, etc) - sometimes they say you can have the underlying issues and something can "trigger" it, maybe that is what they mean in your friend's daughter's case.
 
Good luck to her!!
32 yr old Female
Crohn's Colitis
DX 12/06
 
Currently on Remicade, trying to remember to take Multivitamin and Calcium, need to start taking Probiotics and Omega 3-6-9 and Vitamin D
 
 


WantRelief
Regular Member


Date Joined Feb 2006
Total Posts : 261
   Posted 2/7/2010 7:55 AM (GMT -7)   
Before I was officially diagnosed with CD, they thought I probably had antibiotic induced colities. I has this strange red spot on my leg that was red, hot,hard and very painful.  My doc and I decided that it must be a spider bite and treated me with some hefty antibiotics. Shortly after the antibiotic course was finished, my stomach started having the pains and the constant diarrhea set in. Low and behold the spot on my leg remained.  He admitted me to the hospital when the pain in my stomach became unbearable and I started vomiting.  They did a c-scope while in the hospital and discovered I had crohn's disease. Turns out the spot on my leg was an erythema nodusum. To this day I get the EN flaring before my stomach starts up.
33 year old female
CD of Terminal Illeum and Rectum Diagnosed 12/04
Unable/Unwilling to use immunosuppressents due to Melanoma history in 2000.
Illeocolonic Resection 1/08  (18 inches of terminal illeum, illeocecal valve, right colon and appendix)
Current Meds: Pentasa, Fosomax, Iron, Vitamin b12 injections, Vicodin as needed, Entocort 6mg for maintanence.
November'09 colonoscopy shows reoccurance at anastamosis and active disease in sigmoid and rectum


hld4good
Regular Member


Date Joined Jan 2010
Total Posts : 193
   Posted 2/7/2010 10:47 AM (GMT -7)   
The Merck Pharm. co. website describes the causal effect. They make a class of anti-biotics call cephalosporins which cause antibiotic-induced colitis. They explain that yet another antibiotic is used to treat it. Has anyone been thru this treatment and which antibiotic was used? Thanks.
Age 58, Crohn's since age 21
3 bowel resections, 1980,88,95
1 fistula repair, 2005
probiotic
digestive enzymes
L-glutamine powder 3 times a day
sublingual B-12 and B complex
2 T. cod liver oil
2 tsp. tart cherry juice concentrate
Multiple vitamin, 2,500mg vit. C, 1,000mg calcium mag.


PV
Veteran Member


Date Joined May 2006
Total Posts : 1177
   Posted 2/7/2010 11:12 AM (GMT -7)   
Hi. I'm very familiar with antibiotic induced colitis - otherwise called pseudomembranous colitis which is typically caused by infection with the bacterium clostridium difficile. My husband got c-diff even though he wasn't on any antibiotics - I think people with IBD are just more prone to getting it, because the flora in the gut is not normal.

With normal people, when no antibiotics are taken, the normal flora in the gut crowds out c-diff, and therefore you don't get infected with it. But when you take antibiotics, the antibiotics are wide-spectrum, and kill not just the bad bacteria, but also the good ones, and imbalances the flora in the gut, allowing c-diff to grow in numbers - thereby causing an infection with c-diff. The antibiotics that are effective in treating c-diff colitis are flagyl, and vancomycin. The normal course of treatment is 10-14 days of antibiotics, and hopefully things should return to normal again.

But c-diff is a dangerous pathogen - it is a very hardy spore forming bacteria that can live in spore form on surfaces and in your gut almost indefinitely (they estimate that the spore can survive on surfaces for 8 months or more, so how long it can survive in your gut, noone knows). The spores can stay in your gut, wait for an opportune clime, and become active and cause relapses. They estimate that 20-25% of people with c-diff infection will have a relapse within 3 months of finishing the antibiotic course. Not to alarm you, but just be prepared should this happen.

My husband has had c-diff twice now, both times with no antibiotic involvement, and both times, he's had to take vancomycin to combat the c-diff infection, because he has adverse reactions to flagyl. He also takes florastor (a yeast) that has been shown to inhibit the growth of c-diff. Also, he takes a lot of probiotics (yogurt & VSL3) everyday to help keep his gut flora healthy.

I recommend pedialyte for keeping hydrated, and soft white foods that doesn't irritate the gut. Also, some people get post infectious IBS because c-diff is pretty bad on the gut - so keep a stable diet, and introduce new foods slowly, and hopefully things will go well.

I hope everything gets better after a short course of antibiotics with no problems.

PV
Husband with Crohn's
Diagnosed March 2003 Ulcerative Proctitis
Diagnosed March 2008 Crohn's & C-diff, hospitalized 45 days
Canasa, Lialda, Remicade, VSL#3, Florastor
In Remission since June 2008
Stopped vancomycin for c-diff Jan 1 2009
C-diff free, until Sep 2, 2009
Fighting c-diff, I guess for life


hld4good
Regular Member


Date Joined Jan 2010
Total Posts : 193
   Posted 2/7/2010 12:13 PM (GMT -7)   
Thank you for the detailed info, PV. I appreciate it so much that you took the time to help my friend with this. Her daughter is only 17 and wasting away. Their physician wanted to confer with a mycologist and bacteriologist before proceeding. Tomorrow he will explain the plan to them. I was relieved that their doc sought advice from a specialist. And, after reading your post, I can tell my friend that her daughter is going to be alright. I will also pass on the info regarding foods. Thanks again!
Age 58, Crohn's since age 21
3 bowel resections, 1980,88,95
1 fistula repair, 2005
probiotic
digestive enzymes
L-glutamine powder 3 times a day
sublingual B-12 and B complex
2 T. cod liver oil
2 tsp. tart cherry juice concentrate
Multiple vitamin, 2,500mg vit. C, 1,000mg calcium mag.


PV
Veteran Member


Date Joined May 2006
Total Posts : 1177
   Posted 2/7/2010 3:11 PM (GMT -7)   
Oh, poor thing. I hope she gets to feeling better really soon. vancomycin has worked really well for my hubby - you start to see improvement in about 2 days. So, the sooner she starts the antibiotics, the quicker she's going to get better. I recommend avoiding lactose, fatty, and fibrous food - plain pasta, plain white bread, plain chicken, chicken noodle soup, etc is probably best. And she will put the weight back on as soon as she starts feeling better - I've seen this with my husband, and she'll be back to her normal weight in no time.

C-diff is more of a problem for people whose immune systems are suppressed or are just frail due to age. I think she'll be just fine, even with relapses, as long as she gets treatment for it.

One more thing: after she stops the antibiotics, she may have a slightly rough course - her gut has been through so much it can take some time to function normally again - many people have some trouble with IBS after a c-diff infection. So, one of the things our GI recommends in the 3-day rule: if you have 3 off color days in a row, it is time to get tested. If you have a bad day, then a decent one the next few days, and then a bad day again, it's probably IBS - just keep your diet stable and keep hydrated and get enough rest. Also, if you see blood in stool, get tested right away.

Glad our experience can help someone.

PV
Husband with Crohn's
Diagnosed March 2003 Ulcerative Proctitis
Diagnosed March 2008 Crohn's & C-diff, hospitalized 45 days
Canasa, Lialda, Remicade, VSL#3, Florastor
In Remission since June 2008
Stopped vancomycin for c-diff Jan 1 2009
C-diff free, until Sep 2, 2009
Fighting c-diff, I guess for life


UC21
Regular Member


Date Joined Oct 2009
Total Posts : 68
   Posted 2/8/2010 1:33 AM (GMT -7)   
wednesday2007 said...
I am not sure what antibiotic-induced colitis is (aside from taking the literal meaning) but the first time i got really sick and was diagnosed with Crohn's Colitis there were a few factors that brought me to that point, one being a course of antibiotics I had been on for the dentist. I also had been sick from whatever flu-bug was going around, so my dr told me that maybe the combo of the flu plus antiobiotics "flipped the switch" for my crohn's. By the time I finally got to my GI I was a complete mess and had to be admitted to the hospital right after my colonoscopy.
I had had mild issues and symptoms for years before that but they were never a big deal (maybe a bit of b in the stool here and there, D, etc) - sometimes they say you can have the underlying issues and something can "trigger" it, maybe that is what they mean in your friend's daughter's case.



Good luck to her!!



I also was on a course of antibiotics when I had my first flare up... I think the antibiotics triggered it for me as well....

I never had any symptoms prior however.
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