Aspirin-a-day alternatives?

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GDen
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Date Joined May 2009
Total Posts : 703
   Posted 2/10/2010 7:52 PM (GMT -7)   
In light of the recent study showing IBD sufferers are many times more likely to suffer clots, are there any alternatives to aspirin that have similar preventative effects? My gastro doesn't recommend regular aspirin (325mg) but said baby aspirin (81mg?) should be okay. Anything thing else? Any supplements?
Cimzia, Asacol


jpnutritionfirst
Regular Member


Date Joined Apr 2009
Total Posts : 383
   Posted 2/10/2010 8:26 PM (GMT -7)   
i recently did a presentation on this topic, here's a review of an article but sorry i don't have a recommendation for anticoagulation, but i doubt anyone would recommend any preventative measures. the risk is quite small and only is probably significant when you have active disease

Spina L, et. al. Thrombosis in inflammatory bowel disease: role of inherited thrombophilia. Am J Gastroenterol. 2006 Feb;101(2):403.

Background
• IBD patients at increased risk for both arterial and venous thrombotic events
• One study estimated incidence of 1.3% amongst IBD patients
• Pathogenic mechanism is unknown
• Factor V Leiden and prothrombin 20210A mutations are the most common genetically determined risk factors in general population
• Aim of study: compare prevalence of these gene mutations in large population of thrombotic IBD patients with that observed in thrombotic patients without inflammatory disorders, matched for sex, age, type and site of thrombosis.
Methods
• 47 patients with IBD (30 with UC and 17 with Crohn’s)
• 94 controls with history of thrombosis in absence of IBD and other chronic inflammatory or myeloproliferative disorders
• All patients were Italian
• PCR analysis to detect factor V Leiden mutation and prothrombin gene mutation 20210A in both study groups
Results
• No significant difference in prevalence of subjects with prothrombotic mutations was observed between UC and Crohn’s
• Frequency of factor V Leiden (p=.035) and G20210A prothrombin mutation (p=.471) lower in thrombotic IBD patients than in thrombotic non-IBD patients
• Overall the combined frequency of mutated alleles was significantly lower in IBD group compared to controls (p=.041)
• For venous thrombosis specifically, prevalence of gene mutations significantly lower in IBD patients than in non-IBD patients
• 69.4% of patients were in active phase of disease at time of thrombotic event
• Prevalence of prothrombotic mutations was lower in clinically active IBD patients compared to those in remission or controls. However, prevalence of prothrombotic mutations in IBD patients who had thrombosis during clinical remission was similar to that observed in control subjects
Discussion
• Data strongly suggest that prothrombtic mutations play minor role in inducing thrombotic complications in IBD
• IBD disease activity is major risk factor – several cytokines and mediators implicated both in inflammatory and in hemostatic responses
Crohn's Colitis diagnosed 6/08
Organic SCD since 4/09
Remicade since 6/09
Boswellia + Natren's Healthy Trinity probiotic + Cinnamon + Wild Oregano Oil + vitamin D + zinc + Barlean's fish oil
Remission


FunGuy
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Date Joined Oct 2009
Total Posts : 1070
   Posted 2/10/2010 8:34 PM (GMT -7)   
Would omega 3 fish oil help prevent clots? I quit taking mine since my colon is bleeding and I think I remember that fish oil "helps" blood flow.
 


Grandpato2
Veteran Member


Date Joined Dec 2009
Total Posts : 681
   Posted 2/10/2010 11:48 PM (GMT -7)   
unh jpnutritionfirst was that a yes or a no?
Male, 54 years old with Crohn's since 15 years old, diagnosed at age 46. Terminal ileum resected 2002. 5 months of remission. Crohn's has now been active since early 2003. Had a gall bladder removed Nov. of 2009. Currently on Remicade every 8 weeks, Nexium, Iron, B-12 injection every 4 weeks, Morphine Sulfate as needed for pain. Cymbalta for long term pain control. 5-asa Salofalk, Entecort, Imuran and Prednisone in the past.


crohnielass
Veteran Member


Date Joined Mar 2009
Total Posts : 1118
   Posted 2/11/2010 6:12 AM (GMT -7)   
Hi,A healthy diet, low-cholesterol foods and plenty of fruits and vegetables can help prevent blood clots and many of the conditions that can lead to blood clots, such as atherosclerosis. In addition, such foods as garlic, ginger, onions, and hot peppers can help reduce platelet stickiness and formation of clots. Fish oils and supplements that add nutrients to the diet are recommended as well.Bev x
Diagnosed with crohns at 13 now 43
Reversal of temp stoma Postponed till ???????
Meds: Iron syrup,Loperimide,Folic acid & Citalopram 60mg (for Anxiety.)


" I may not be there yet, but I'm closer than I was yesterday."


GDen
Veteran Member


Date Joined May 2009
Total Posts : 703
   Posted 2/11/2010 12:59 PM (GMT -7)   
I have found hot peppers to be contraindicated by IBD. Ouch!
Cimzia, Asacol


vixen
Veteran Member


Date Joined Jan 2010
Total Posts : 794
   Posted 2/11/2010 1:12 PM (GMT -7)   

 

Vitamin E is really good for keeping the blood flowing, but you usually have to stop taking it at least 3 weeks prior to any surgery(because of increased risk of bleeding) and if you lose blood through Crohn's I do not know if this would make it worse.

Also, if you do take it, start on a low dose (think it is measured in iu's) believe the lowest is 50. I went on it a few years ago and not knowing much about it started taking the '200' dose-it was forcing the blood to my brain and I literally had a headache for the 6 weeks I was taking them so I stopped-it was a few years later that I learnt that the high dose was causing the headaches and that you need to build up to it.


firecracker1
Regular Member


Date Joined Apr 2007
Total Posts : 208
   Posted 2/11/2010 5:12 PM (GMT -7)   
I take Reishi Mushroom extract.  You can get it at most health food stores. It helps with blood pressure and thins the blood a little. Those taking anticoagulants cannot take Reishi.
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