Vancomycin for C-diff

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blback12
New Member


Date Joined Feb 2010
Total Posts : 3
   Posted 2/12/2010 11:18 PM (GMT -6)   
I have been battling C-diff for two months now. I first was on Flagyl and it didn't work.  I've been to the emergency room already over this and I've been the the doctor twice. I've also had three stool cultures done and all three came back negative.  I finally had a colonoscopy monday and the doctor took biopsy's and he said he was 99% sure it was still c-diff and that I had the strain that was becoming resisitant to Flagyl.  I am now on Vancomycin 250 mg four times a day  and I'm eating yogurt and i just began taking a acidophlis pill also.  I have been on the vanco since Tuesday evening.  Does anyone know how long it will take for me to start noticing the changes?  I've been miserable! Going to school, trying to work and even just doing the normal activities for me is a nightmare becaause I don't know when I have to run to the restroom.  I also have ulcers in my colon.  Please give me as much info as you can! I could really use the help! Thanks!

sickofitall
Regular Member


Date Joined May 2009
Total Posts : 226
   Posted 2/13/2010 1:31 AM (GMT -6)   
I had Cdiff and took repeated doses of Flagyl and Cipro with no luck. I would feel good for two days then it would reappear. Finally was given Vanco for 14 days. It took awhile to work. Maybe by day 10 I was starting to feel better. After was no fun either. Once the Cdiff cleared up the crohns flared bad. It was like it damaged a part of my intestines for good, same spot still hurts till this day when I flare. But remicade began to heal the damage and the flare got under control. My stomach was messed up during that time. I ate very bland. Yogurt, plain sandwiches, crackers, ensure etc. Also took a ton of probiotics (not sure if this helped or not but I was desperate). Good luck and eventually it will go away. I also cleaned my house with clorox commercial grade bleach to make sure I got rid of it. So far so good. No reoccurances. I was determined!
Current meds:  Remicade and probiotics
Tried:  Prednisone, lialda, antibiotics all failed attempts.
 


PV
Veteran Member


Date Joined May 2006
Total Posts : 1158
   Posted 2/13/2010 10:22 AM (GMT -6)   
My husband has struggled with c-diff. In March 2008, he was admitted to the hospital with a c-diff infection (at this point, we didn't know he also had crohn's). They put him on vancomycin, and he still didn't get better. Finally they did a full colonoscopy, and found an area of severe inflammation with granulomas which is how we figured out he had crohn's. They put him on 120 mgs of solumedrol, but his crohn's did not respond to that at all. So, they added remicade and after 2 doses he was well enough to come home. It was quite an ordeal. He is still on remicade, Lialda and Canasa to control the crohn's.

This past September, he tested positive for c-diff again, but this time, the remicade kept the crohn's in check. What a huge difference that made. It made c-diff more of a nuisance than a major medical crisis. 2 weeks of vancomycin, and he was c-diff free again, and continues to remain c-diff free.

Vancomycin is extremely effective at fighting c-diff. I have not heard of any c-diff strains that are vancomycin resistant, thankfully. My husband usually started feeling better around day 3 of taking the vancomycin, when he was fighting c-diff. Of course any antibiotics themselves give my husband the runs, but he started feeling better in terms of lesser cramping, less frequent bowel movements, more mushy stool than complete watery diarrhea.

If you aren't responding to vancomycin, there's probably some level of crohn's going on. C-diff seems to aggravate crohn's quite a bit (at least this is true in my husband's case), and causes even mild cases of crohn's to have some really acute flare ups. I think without c-diff, my husband will have pretty mild crohn's. I think it is time to treat the crohn's aggressively as well. What meds are you on for the crohn's? My husband needed remicade, and it sounds like sickofitall needed remicade to control the crohn's flare up too.

Please talk to your GI about aggressively treating the crohn's - based on our experience, I strongly suspect that there is more than just c-diff causing problems; I suspect that crohn's is also flaring to some extent, because vancomycin really does a good job of treating c-diff infections.

I hope you get some answers soon, and start feeling better really soon.

(((Hugs)))
PV
Husband with Crohn's
Diagnosed March 2003 Ulcerative Proctitis
Diagnosed March 2008 Crohn's & C-diff, hospitalized 45 days
Crohn's in Remission since June 2008
Reactive Arthritis Nov 2009
Currently c-diff free
Canasa (1gm), Lialda (4.8 gms), Remicade (6 weeks), Pred (5mg every other day)
Hoping to stop pred, and move remi back to every 8 weeks soon


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14994
   Posted 2/13/2010 10:29 AM (GMT -6)   
Just wanted you to make sure that you are taking your probiotics at least 2 hours after your antibiotic. Otherwise they just cancel eachother out if taken at the same time. Good luck and hope you get feeling better soon. Hugs!
Gail*Nanners* Co-Moderator for Crohns Disease & Anxiety/Panic
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

heatmiser
Veteran Member


Date Joined May 2003
Total Posts : 1669
   Posted 2/13/2010 11:13 PM (GMT -6)   
I had been hospitalized due to c-diff last September and they gave me flagyl, cipro and vancomycin.  I got cleared of c-diff before I left hospital but got worse before I got better.  May have been flaring at same time.  I think I may have it again, but my c-diff test was negative.  It sounds like we need better tests for c-diff. 
Dxd CD in 2003. Scope Aug/09 shows UC.
Meds: Colazal, prilosec, darvocet


j_web
Regular Member


Date Joined Nov 2009
Total Posts : 204
   Posted 2/14/2010 2:12 AM (GMT -6)   
Hi,

I'm also one of the people whose samples always come back negative for c-diff - unless they are retrieved via scope, then they're positive.

On vanco, it took me just over a week to start feeling better. I ended up using vanco about 4 times because the c-diff kept coming back. I think the first 2 times I took it for 10 - 14 days, the last two times were longer (6 weeks perhaps?) , and I would start off at the highest dosage and taper each week. I think I've been c-diff free for over a year now.

Good luck!
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