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New Member

Date Joined Feb 2010
Total Posts : 1
   Posted 2/13/2010 10:46 AM (GMT -6)   

New to the forums, and frankly have never really posted anywhere about my disease, so this is a first.  But not being able to find anything concrete, I'll just pose the question!
I've had Crohn's disease for about 10 years.  A mild case I'm fortunate to say.  All the same I recently went through a rough bought where I was experiencing a great deal of pain, moreso than I have ever felt before.  After trying to manage it with a light diet, unsuccessfully, I went to my Doctor who upgraded my "status" from mild to moderate and perscribed me Mezavant.  In the past I had only taken Prednisone.
Initially the drug seemed to work very well and my symptoms, the pain and bleeding, subsided.  I was over the moon.  I started thinking of it as a miracle drug.  This two month pain-free reprieve was incredible, but recently I am noticing a return of the symptoms.  The bleeding is back, although only slight, and the pain in my stomach is also back.  My fear that the drug has run it's course in my system is mounting and was wondering if anyone else has noticed anything similar with Mezavant.
As I am steadily, and slowly, declining, I have increased my regularity of taking the drug.  I take it everyday, four tablets.  In the two months I have forgotten to take the drug only a few times, or forgotten it at home and so couldnt take it, but didnt notice ANY effect. 
Any experiences or advice?
Thanks so much for reading,

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 2/13/2010 10:53 AM (GMT -6)   
Mezavant is a med in the Mesalamine family. I have not taken that med, but take a sister med called Asacol and it works well for me. Maybe its time for you to move up to something like Imuran or 6mp. Many have had great success with these meds. Hugs and welcome to Healingwell!
Gail*Nanners* Co-Moderator for Crohns Disease & Anxiety/Panic
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Veteran Member

Date Joined Oct 2004
Total Posts : 3042
   Posted 2/13/2010 4:43 PM (GMT -6)   
Hi and Welcome to Healing Well, I agree with Nanners about the Imuran. Also You can talk to
your doctor about Remicade or Humira. I have done both drugs and they gave me back a normal life.
Hi, I am teddybearweiser, I am a male.
I was diagnosed with crohns disease when i was admitted to the hospital

in 1992, in Jan of 1993 I was back in the hospital for surgery for my crohns. I had part of my right colon resectioned with ilecolonstomy.

My GI doctor has me on and Humira. B-12 injection once a month.
Also diagnosed with Rheumatoid Arthritis.

Regular Member

Date Joined Apr 2009
Total Posts : 166
   Posted 2/13/2010 5:54 PM (GMT -6)   
I took Mezevant for a short time and it did not agree with me at all. It requires that you take it carefully as instructed because it is a once a day med rather that a several dose a day med.

Having said that, it is also only a maintenance medication so it does not work to control a flare up. I tried to double up my Salofalk (same medication as Mezevant in a different formula) at the beginning of my recent flare and it did nothing but give me a headache.

If you are flaring you will likely need something else to get it under control. After that you can go back to Mezevant if it agrees with you and use that as your maintenance medication.
45 years old. Diagnosed with moderate to severe Crohn's in April 2005. Hiatus hernia diagnosed in 2008. Had Crohn's under control until March last year when I had a major flare up and ended up in hospital. Diagnosis is now CD and IBS. Getting it under control again.
Currently taking: Salofalk 2000 mg, Nexium, Calcium and Vitamin D, Matamucil, Yogurt for probiotics, Salofalk suppositories as needed.

New Member

Date Joined Apr 2010
Total Posts : 3
   Posted 4/2/2010 3:37 AM (GMT -6)   
Hi everyone,
joined today after seeing posts aabout Mezavant. I was diagnosed with UC 18months ago and initially was treated with predsole which did the trick. Have had 3 flare ups since and this time quite badly. Have been taking 4 Mezavant tablets a day for 10 days now coupled with Salofalk retention  enema and it's doing the trick. Feel really good and the bleeding is stopping - finally!
I have also seen posts on people with thyroid problems. My underactive thyroid was diagnosed 5 years ago so maybe that's why my Doctor has just reduced the thyroxin dose I'm on.  Has anyone else had it diagnosed this way around? Thyroid problem then  UC?

Veteran Member

Date Joined Jul 2006
Total Posts : 6927
   Posted 4/2/2010 8:10 AM (GMT -6)   
Both thyriod mods have IBD, so it is not unheard of, but I was dx with crohns first then a thyriod problem.
Forum Co-moderator - Crohn's Disease/Thyroid Disorders:_All comments have the caveat contact your local health care provider.

I will find a way or make one. –Phillip Sidney 1554-1586

All that I am and all that I shall ever be, I owe to my Angel Mother.

The Bucket List- Have you found joy in your life?  Has your life brought joy to others?

Make sure your suffering has meaning…

New Member

Date Joined Apr 2010
Total Posts : 3
   Posted 4/2/2010 10:58 AM (GMT -6)   


Veteran Member

Date Joined Dec 2009
Total Posts : 681
   Posted 4/3/2010 2:13 AM (GMT -6)   
Is 4 pills a day the max dose? If not perhaps your next move is to get Dr. to up the dose and see what happens. I first tried Salofalk but the side effects made me stop, then I tried Asacol and I'm having much better results with it. Both these are also 5-asa's so you might also want to try another brand to see how you react to it. Rob
Male, 54 years old with Crohn's since 15 years old, diagnosed at age 46. Terminal ileum resected 2002. 5 months of remission. Crohn's has now been active since early 2003. Had a gall bladder removed Nov. of 2009. Currently on Remicade every 8 weeks, Nexium, Iron, B-12 injection every 4 weeks,5-asa Asacol, Morphine Sulfate as needed for pain. Cymbalta for long term pain control. 5-asa Salofalk, Entecort, Imuran and Prednisone in the past.

New Member

Date Joined Apr 2010
Total Posts : 3
   Posted 4/4/2010 1:08 PM (GMT -6)   
Many thanks Grandpato2. Yes 4 tablets is the max dose and you can only stay on them for 8 weeks. Can I ask you what the side effects were form Salofalk?
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