When did Humira kick in for you?

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isergodur
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Date Joined Jan 2009
Total Posts : 831
   Posted 2/23/2010 4:04 PM (GMT -7)   
I have been on Humira now for 2 months and I am getting worse by the day.

I got my last remicade infusion in end of august 09
Then I went through 16 weeks with out nothing except from asacol.

Now I am feeling rather bad well I feel like I have just eaten a bowl of razer blades :S

I was just wondering how long it took for Humira to work for you?
25 year old female
Diagnosed with :
Endometriosis march 2007
Anxiety disorder august 2007
CD/UC they dont know witch October 2008
Autoimmune Hepatitis in July 2009

Medication - Humira, Asacol, Cipralex and Cerazette.
Past medication Remicade, Imuran
My wonderful dogs :) ~ www.poodle.is ~


Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7077
   Posted 2/23/2010 5:53 PM (GMT -7)   
Did you have the four initial injections and then two weeks later, 2 more injections as the loading dose? If not, then it might take some time for the Humira to help.

If you did have the loading doses, then you should be getting some effect from your injections. If you are only feeling worse, then it could be possible you are having a flare or other problem. Have you called the GI's office? I think you need to get into see him/her.
Moderator Crohn's Disease  & Osteoarthritis Forums
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, asthma, severe allergy and a host of other medical problems.
 


Aimee =)
Veteran Member


Date Joined Jun 2004
Total Posts : 1020
   Posted 2/23/2010 7:33 PM (GMT -7)   
I responded very quickly to both Remicade and Humira - Humira was within a week or two.
 

Rider Fan
Veteran Member


Date Joined May 2008
Total Posts : 1445
   Posted 2/23/2010 8:27 PM (GMT -7)   
Three months.
33 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. Proferrin iron pills.

Tried SCD, didn't work, now avoiding gluten and dairy.


Go Saskatchewan Roughriders!


spookyh
Veteran Member


Date Joined Oct 2008
Total Posts : 1342
   Posted 2/23/2010 10:31 PM (GMT -7)   
I think it was about 2 months before I got better.
34 years old, Crohn's disease for 15 of them
Resection of ileocecal valve on 09/22/09
Current Meds: LDN, Pentasa, Effexor XR, Zyrtec
Supplements: 3 kinds of Fish Oil, Multi-Vitamin, Vitamin D, Calcium, Magnesium, Coconut Oil, Garlic Oil, CoQ10, Enzymes
SCD since 12/01/08 - eating Stage 3 foods


isergodur
Veteran Member


Date Joined Jan 2009
Total Posts : 831
   Posted 2/24/2010 9:40 AM (GMT -7)   
Yes first I got 4 shots then 2 and now I get 1 every other week.

It took Remicade 4 infusion to start working for me.

I am not feeling anything from the first 9 shots of Humira.

But I hope we will give it a change for a little bit longer.
25 year old female
Diagnosed with :
Endometriosis march 2007
Anxiety disorder august 2007
CD/UC they dont know witch October 2008
Autoimmune Hepatitis in July 2009

Medication - Humira, Asacol, Cipralex and Cerazette.
Past medication Remicade, Imuran
My wonderful dogs :) ~ www.poodle.is ~


dietcoke
Regular Member


Date Joined Jul 2008
Total Posts : 186
   Posted 2/24/2010 12:01 PM (GMT -7)   
I like you got worse on Humira. I gave it three months but it definitely made me worse.
40 years old female
Salmonella - 1996
Crohn's Colitis in entire colon - Diagnosed in 2000
Hypersensitive/Allergic to Asacol/Pentasa/Budonside/6MP/Immuran/Humira/Remicade, and more
Past meds that worked: Cipro, Prednisone

Daily: Folic Acid, Omega 3, Multi-Vitamin, Cipro 1000mg, yummy homemade yogurt


isergodur
Veteran Member


Date Joined Jan 2009
Total Posts : 831
   Posted 2/24/2010 12:48 PM (GMT -7)   
dietcoke said...
I like you got worse on Humira. I gave it three months but it definitely made me worse.


it seems like it I have been getting worse every day but maybe it is not Humira fault maybe it is just not working for me and that is the reason why I am getting worse.

after the fist shots I did feel a slight difference for one or two days now I see no difference
25 year old female
Diagnosed with :
Endometriosis march 2007
Anxiety disorder august 2007
CD/UC they dont know witch October 2008
Autoimmune Hepatitis in July 2009

Medication - Humira, Asacol, Cipralex and Cerazette.
Past medication Remicade, Imuran
My wonderful dogs :) ~ www.poodle.is ~


Wolfie40
Veteran Member


Date Joined Dec 2008
Total Posts : 947
   Posted 2/24/2010 5:57 PM (GMT -7)   
I really hope you feel better soon.
I can't tell if humira is working or not as I have felt ok.
The doc noticed that the Crohns was back when I had a C scope.
Diagnosed with Crohns in 2001
First and hopefully last Ileocecectomy 2/18/2009

Medications:Humira,  Asacol, FolicAcid,  Multivitamin, 1000mg Calcium, Vitamin D, Probiotics, Pepcid Complete, Questran,  Monthly B-12 injections.

Living a Great life with my Wife and my two Chocolate Labs
Hunter & Hailey.
I love them dearly.


Sunaddict
Regular Member


Date Joined Jun 2009
Total Posts : 354
   Posted 2/24/2010 8:12 PM (GMT -7)   
doctor told me to be real patient with humira, can take up to 6 month to see any sort of effects.
I saw a notice with in 2 months, remission in 4 months.
My flares are coming back tho and I no longer can eat things that I was able to 2 months ago(actually no longer able to keep a meal in me). But I am also getting married in a month so I am wondering if it's just bride stress, or lost the effectness of humira!! ?

Hope it works out for you, and real quick.
Tracy from montreal. Dx with Cd 7 years ago but un-Dx for 10 years. Meds currently taking;Imuran (1 and half tab daily)Humira (bi-weekly) pentasa, been on prent 4 times but horrible side effects doc wont use this on me anymore. Humira has put my CD into remission, after using remicade for a year and half which caused remi induced arthritis. I am currently (most days) arthritis free. Currently dealing with endometriosis.


debilitated
Regular Member


Date Joined Jan 2010
Total Posts : 448
   Posted 2/24/2010 9:40 PM (GMT -7)   
6 months to work? I Extremely disagree with that. They say even at week 32 on REMICADE.. Only 10% of patients see remission by then.. Otherwise stop..

Don't Let the Crohn's Progress further. It wont do major damage while humira is in your system but consider looking at cimzia or even another line of therapy.

Humira worked for me the day i got it. Thats just me though. 2 months and YOU feel worse?

My doctor is top 5 in the nation at the university of Chicago. He says you cant go by the book with Crohn's.
Surgery, Drugs, Changes are ALL BASED on The patient. Not tests and numbers. (Per say)

I have a 15cm Shoe string Stricture in my small bowel.. But believe it or not, I eat Steak, Fibercon PILLs, Chicken, Chinese food... Never once an obstruction.. He said that you know what, Surgery isn't an option than yet.

I was happy to hear that..

Please Go with how you feel, Tell your doctor everything. Everything you eat, can tolerate.. etc.. It helps your EASE of mind and also gives your doctor a more "feel for you" aspect.

isergodur
Veteran Member


Date Joined Jan 2009
Total Posts : 831
   Posted 2/24/2010 9:45 PM (GMT -7)   
Thanks all of you for your reply I guess I will have to give it time and see what happens.
I just do not want to go on pred and I have told my doctor that a million times so I will see what he thinks.

The problem is I am getting really bad pain, like someone is playing in the with little razor knives
I am taking pain killers with 500 mg Paracetamol and 10 mg Codeine but it is not working very well.
Maybe I have to up the dosage.


And congratulation Tracy on your upcoming wedding ;)
It is probably just stress that is making your tummy upset at the moment.

I know that just by thinking about doing something important makes me sick
25 year old female
Diagnosed with :
Endometriosis march 2007
Anxiety disorder august 2007
CD/UC they dont know witch October 2008
Autoimmune Hepatitis in July 2009

Medication - Humira, Asacol, Cipralex and Cerazette.
Past medication Remicade, Imuran
My wonderful dogs :) ~ www.poodle.is ~


Becky77
Veteran Member


Date Joined Dec 2005
Total Posts : 1768
   Posted 2/24/2010 10:30 PM (GMT -7)   
I don't know how long it took it to help me, but I had problems with obstructions, and haven't had one (knock on wood) in over 2 years (since being put on humira)!!!

Maybe you've developed a tolerance to pain medicines? Over the years, I've found that I have to take a higher dose for it to help fully. Some doctors see it as drug seeking when you tell them that, but the ER near me can look at my history and see how many times I've been admitted and know it's because I've been given meds over the course of the last 13 years and obviously have developed a tolerance. Hopefully your dr is understanding and can work with you to get pain control.

Don't let things get out of control before you do something! Call your GI and figure out a plan! Hopefully they have a plan and get you to feeling better soon.
Becky

32 yr old female-dx with Crohn's in '97 after emergency resection and appendectomy, 2nd resection '05, Bilateral pulmonary emboli 10/09
Currently on Humira, Omeprazole, Effexor, Seroquel, Calcium, Vit D, Coumadin


Djin
Regular Member


Date Joined Jan 2010
Total Posts : 265
   Posted 2/25/2010 5:13 AM (GMT -7)   
Are you on LIQUID DIET??

When I feel exactly like that, only Buscopan and liquid diet (soy smooths, blended broths), for some days (3-4) give me relief. If I eat ANYTHING solid, even rice ou potatoes, I get cramps.

Its a proven fact tha a liquid diet can kick a remission!
 
-------------------------------------------
Diagnosed in nov/94 - Started with Prednisone, followed by Pentasa, entocort, flagyl, Imuran, Cipro, etc.
Blockage - First Surgery 2001 (no ressection)
Severe bleedind - 2003 - Stopped by 60mg of Prednisone
Stricture leading to a ressection in Dec/2008 - Second Surgery
Now on Remicade + 100 mg Imuran + Iron (sort of remission, not sure at all)
 


LauryLu
Regular Member


Date Joined Dec 2008
Total Posts : 75
   Posted 2/26/2010 9:50 AM (GMT -7)   
Yes I agree totally that a liquid diet jump starts you out of a flare. I'm going through it now and even if I ate mashed potatoes my intestines would be wrathing in severe pain. A week of pureed soups, broths and juice does the trick.
 
My experience of Humira has been a long one. I was on it for well over 6 months and still not feeling the best. My energy level rose immediatly while starting and also my joint pains stopped but the stricturing area of my illeum was giving me lots of pain. This may be bc I have so much fibrotic scar tissue and no meds will help with this until I get surgery to remove it. But I was noticing that every time before my two week injection, I would feel kind of lousy. So my GI bumped up the injections to every 10 days and started me on entocort. The combo was a winner! The only reason I am flaring right now is because I began tapering to get off the entocort (mainly bc any form of steroid messes with my emotions too much). So I would say to give it time. Some patients need a special combo of the Humira and something else (ex. Imuran, Entocort..) in order to see full effects taking place. Have patience and be open-minded to try new things.
27 yo Female, Crohn's, stricturing type- terminal illeum.
symptoms at age 2....Diagnosed at 6
Bal-resection 1998
Have tried it ALL Currently on Humira, Fish Oil, D3, Entocort, B-12 shots, Align, Multi


Crohnie4Life
Regular Member


Date Joined Jan 2010
Total Posts : 69
   Posted 2/26/2010 3:29 PM (GMT -7)   
I took Humira for almost two years. The loading doses helped out quickly. I had minimal symptoms for almost a year. Then I went to one pen a week instead of two a month. In the end, I was on two pens a week. Finally, the Humira just stopped working. Sucks. Now I'm on an Ustekinumab trial.
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