Methotrexate - Remicade and TNF's - and TYSABRI (what would you consider to be most risk)

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debilitated
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Date Joined Jan 2010
Total Posts : 448
   Posted 2/24/2010 9:15 PM (GMT -7)   
Ive been on all the above except MTX and Tysabri. I Refuse to try TYSABRI.

Every drug has side effects. And yes, this is probably a question for my pharmacist or doctor based on data.. But most of our doctors dont have Crohn's. (Most!)

I think I will be starting MTX soon. Thanks!

I care about my liver.. haha.
I have been through so much and I want remission so bad. It's been tooooo long.

What do you consider "more risky" Or Dangerous" Or skeptical to go on.

Post Edited (debilitated) : 2/24/2010 9:20:22 PM (GMT-7)


Rider Fan
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Date Joined May 2008
Total Posts : 1445
   Posted 2/24/2010 9:18 PM (GMT -7)   
Good luck! Make sure you take folic acid as well.
33 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. Proferrin iron pills.

Tried SCD, didn't work, now avoiding gluten and dairy.


Go Saskatchewan Roughriders!


debilitated
Regular Member


Date Joined Jan 2010
Total Posts : 448
   Posted 2/24/2010 9:19 PM (GMT -7)   
Sorry, My post was looking for opinions based on what OTHERS thought was most Risky...

Rider Fan
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Date Joined May 2008
Total Posts : 1445
   Posted 2/24/2010 9:22 PM (GMT -7)   
I guess Tysabri is more risky. But I think it's also more effective. Nothing wrong with trying MTX first, I guess. It's what I did before I went to Humira.
33 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. Proferrin iron pills.

Tried SCD, didn't work, now avoiding gluten and dairy.


Go Saskatchewan Roughriders!


MMMNAVY
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Date Joined Jul 2006
Total Posts : 6927
   Posted 2/24/2010 10:18 PM (GMT -7)   
MTX injections have worked the best for me so far and I have been on them for 3 years now. (tried remi, humira, and all the oral drugs)
Forum Co-moderator - Crohn's Disease/Thyroid Disorders:_All comments have the caveat contact your local health care provider.

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debilitated
Regular Member


Date Joined Jan 2010
Total Posts : 448
   Posted 2/24/2010 10:29 PM (GMT -7)   
Cool navy, I know you have some experience. With the Throat crohns, etc.. etc.. and you know your meds. Would you say if i was on 3 TNF's..... go for Mtx?

lilcrohnieUK
Regular Member


Date Joined Dec 2007
Total Posts : 414
   Posted 2/25/2010 3:39 AM (GMT -7)   
I see remicade, the TNF's etc as most risky. Mainly as they are newer. Methotrexate has been around for decades, I myself have been on it for the best part of a decade. All drugs have risks, my only fear with the newer drugs is that long term issues may not have been identified yet. And they are SO powerful! Just one dose of remicade is powerful enough to get me from deathbed to alive n kickin in a matter of days and keep me that way (with the support of MTX) for up to 3 years! Thats why I refuse to have them on the 8-12 week schedules and just have them when I am actually flaring, when I flare it is severe and I go downhill quick and they make it do a complete 180 so it must be seriously strong and it scares me too much to put it in my body regularly especially when there is no active disease to fight.
 
 


tsitodawg
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Date Joined Sep 2006
Total Posts : 845
   Posted 2/27/2010 3:04 AM (GMT -7)   
In my own personal opinion, all of the medications have risks involved with them but it depends on what is best for your type of Crohn's disease. Even the TNFs are so different in how they have an effect on you that it really is a personal preference. I have tried all of them (Remicade, humira, cimzia) and have had to go back to Remicade. My G.I. was not as comfortable with Tsabri due to the possiblity of brain infection but we are considering whether the risk is worth the benefit. I have also used methotrexate and 6 mp alone and with my TNFs but they always cause my liver levels to go wacko despite providing my with the most relief I have ever felt.
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