6-MP Hair Loss

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Date Joined Feb 2009
Total Posts : 82
   Posted 3/1/2010 3:26 PM (GMT -6)   
I just started taking it about a month ago and recently I noticed my hair coming out by the fistful. I've had to unclog my shower drain every week or so and clean out my hair brush every other day.  My hair is already thin without any additional hair loss.
For anyone who experienced hair loss as a side effect of 6-MP, how bad did it get for you?
22 years old, Female.
Diagnosed with Crohn's Ileocolitis November 2008.
Currently taking Remicade, 50 mg 6-MP, 5 mg prednisone (slow taper).

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Date Joined Nov 2003
Total Posts : 7055
   Posted 3/1/2010 5:55 PM (GMT -6)   
Imuran is metabolized to 6-mercaptopurine [6-MP] in the body. I wrote the following sometime ago in response to a similiar question:

Azathioprine [Imuran, Azacan, etc] is a folic acid antagonist. Folic acid [folate; B9] is found in highest concentrations of foods that people with CD often avoid, fresh, uncooked fruits and vegetables. While your doctor may have measured your folate level in your blood and pronounced it "normal" it still could be too low. A folate level on the lower end of the normal range in a person with CD can lead to deficiency. Since azathioprine interferes with folate, and your diet might be insufficient in folate, deficiency can occur. My doctor prescribed Folic Acid 1 mg daily. Within two months of adding this, my excessive hair loss had stopped and I was regrowing hair.
Moderator Crohn's Disease  & Osteoarthritis Forums
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, asthma, severe allergy and a host of other medical problems.

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