Methotrexate with fistula?

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debilitated
Regular Member


Date Joined Jan 2010
Total Posts : 448
   Posted 3/6/2010 4:56 PM (GMT -7)   
remicade healed mine.

can mtx make an abscess or fistula worse?

Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 3/7/2010 8:30 AM (GMT -7)   
I doubt it. MTX would help to tamp down the inflammation, so I think it would make things better vs worse. JMHO
Gail*Nanners* Co-Moderator for Crohns Disease & Anxiety/Panic
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 3/7/2010 8:30 AM (GMT -7)   
I doubt it. MTX would help to tamp down the inflammation, so I think it would make things better vs worse. JMHO
Gail*Nanners* Co-Moderator for Crohns Disease & Anxiety/Panic
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

sr5599
Veteran Member


Date Joined Aug 2007
Total Posts : 1202
   Posted 3/7/2010 7:18 PM (GMT -7)   
I think it can actually help with fistulas. Not as high a rate as Remicade by any means but they've done some studies...
1 fistula, crohn's colitis, limited to large intestine
Compounded budesonide 3mg/daily, Cimzia, MTX . Dx Osteoporosis 10/08 started Forteo 1/27/09


smallgit
Regular Member


Date Joined Feb 2010
Total Posts : 29
   Posted 3/7/2010 8:53 PM (GMT -7)   
METHOTREXATE CAN MAKE FISTULAS WORSE. use it with caution. it made my fistula worse. and caused neutropenic fever. it dropped all of my blood cells ---WBCs particularly and I had to be readmitted because of it. so watch your WBC count and your LFTs (liver function tests) --Bilirubin, AST, ALT (or SGOT/SGPT). It's a SUPER powerful chemotherapeutic agent so just be careful.
A survivor of CAPS - Catastrophic Antiphospholipid Syndrome with infarcts in one kidney, spleen, liver, and intestines in July '09

Surgeries: cholecystectomy, partial enterectomy x 2 with surgical complication of EC fistula
Meds: Lovenox daily subQ injections, Metoprolol for hi BP
Previous Meds: Ritoxan, Methotrexate, Plasmapheresis, innumerable blood transfusions, and antibiotics galore.


sr5599
Veteran Member


Date Joined Aug 2007
Total Posts : 1202
   Posted 3/7/2010 10:45 PM (GMT -7)   
Here's a quote from a study regarding fistulas and methotrexate:
"Thirty-seven courses of methotrexate therapy were given to 33 patients with luminal and/or fistulizing Crohn's disease. In 16 patients with fistulas, four (25%) had complete closure, five (31%) had partial closure and all had failed or were intolerant to 6-mercaptopurine therapy."
1 fistula, crohn's colitis, limited to large intestine
Compounded budesonide 3mg/daily, Cimzia, MTX . Dx Osteoporosis 10/08 started Forteo 1/27/09

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