Is 25mg of methotrexate too much or standard? Even if im underweight.

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Regular Member

Date Joined Jan 2010
Total Posts : 448
   Posted 3/10/2010 7:37 AM (GMT -6)   
i start my 25mg today. 25mg seems like it's alot.

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 3/10/2010 8:33 AM (GMT -6)   
I think that is the usual starting dose. Good luck!
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Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
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Regular Member

Date Joined Mar 2008
Total Posts : 381
   Posted 3/10/2010 9:34 AM (GMT -6)   
I started with 25mg. Dropped to 15mg after about four months.

57 yr. old F dx. CD 07/07
Was on prednisone for three months but no medication for next 11 months.
Started weekly methotrexate injections 09/22/08.
Lap assisted sigmoidoscopy done May 11/2009

Veteran Member

Date Joined Jul 2006
Total Posts : 6927
   Posted 3/10/2010 9:46 AM (GMT -6)   
Started out at that went up for a while. Then after 2 1/2 years went down to 15.
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Veteran Member

Date Joined Aug 2007
Total Posts : 1202
   Posted 3/10/2010 11:23 AM (GMT -6)   
When I tried it 3 years or so ago I started at 25 mg. That's what I'm on now too. I do take my folic acid though. I think it's supposed to counter some of the side effects. Others likely know more about that than I do.
1 fistula, crohn's colitis, limited to large intestine
Compounded budesonide 3mg/daily, Cimzia, MTX . Dx Osteoporosis 10/08 started Forteo 1/27/09

Veteran Member

Date Joined Mar 2005
Total Posts : 589
   Posted 3/10/2010 11:24 AM (GMT -6)   
That is what I started at and have been at for almost a year now.
I think that is the starting dose and they can adjust it per your lab work
Diagnosed with Lupus - April 2002
Diagnosed with Crohn's Disease (and all the lovely things that come with it) - January 2003 (problems since early 1990)
Fibromyalgia 2005 
Normal Meds:  Ambian 10mg, Flexeril 10mg as needed, Plaquenil 400mg, MTX 25mg Injection weekly, 1000mg Canasa Supp. as needed, Probiotics

Regular Member

Date Joined Dec 2007
Total Posts : 414
   Posted 3/10/2010 12:54 PM (GMT -6)   
Its standard, and will be the same for men and women of all weights. I started at 25mg, they tried to reduce to 15mg after about a year and I flared so they put me back up to 25mg and I've stayed at 25mg for the past 7 years and during that time my weight has fluctuated between 100lbs and 120lbs.

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