During my 3rd infusion of Infliximab i had a bad reaction, nausea, hives, breathing difficulties, the med staff ran to me. Since then I have had steroid and antihistamine prior to each infusion. I have to change to Humira because the Infliximab stops working after 4 weeks. On Tuesday I will do my first injection with the assistance of a nurse at my house and without steroid and antihistamine. The doctor thinks I will be ok because Humira is different, more humanised, but, I am still scared. Question: Has anyone had reaction to Inflixmab, changed to Humira and how is it. Help please.