just wanted to answer your RPLS worries with Ustekinumab.

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debilitated
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Date Joined Jan 2010
Total Posts : 448
   Posted 3/14/2010 1:03 PM (GMT -7)   
past months i noticed a few of you were concerned of a similar "tysabri" PML type reaction or brain issue with Ustekinumab.

Here is the DATA: Hope it helps.

Reversible posterior leukoencephalopathy syndrome:
One case of reversible posterior leukoencephalopathy syndrome (RPLS) was observed during the clinical development program, which included 3,523 ustekinumab-treated subjects. The subject, who had received 12 doses of ustekinumab over approximately 2 years, presented with headache, seizures, and confusion. No additional ustekinumab injections were administered and the subject fully recovered with appropriate treatment.

If RPLS is suspected, discontinue ustekinumab and administer appropriate treatment.

RPLS is a neurological disorder not caused by demyelination or a known infectious agent. RPLS can present with headache, seizures, confusion, and visual disturbances. Conditions with which it has been associated include preeclampsia, eclampsia, acute hypertension, cytotoxic agents, and immunosuppressive therapy. Fatal outcomes have been reported

debilitated
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Date Joined Jan 2010
Total Posts : 448
   Posted 3/14/2010 1:04 PM (GMT -7)   
Immunosuppressive agents/phototherapy: The safety of ustekinumab in combination with other immunosuppressive agents or phototherapy has not been evaluated. Ultraviolet-induced skin cancers developed earlier and more frequently in mice genetically manipulated to be deficient in both IL-12 and IL-23 or IL-12 alone.1

debilitated
Regular Member


Date Joined Jan 2010
Total Posts : 448
   Posted 3/14/2010 1:05 PM (GMT -7)   
The safety data reflect exposure to ustekinumab in 2,266 psoriasis subjects, including 1,970 exposed for at least 6 months, 1,285 exposed for at least 1 year, and 373 exposed for at least 18 months.

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice

jan2003
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Date Joined Jul 2004
Total Posts : 92
   Posted 3/14/2010 1:36 PM (GMT -7)   

DB,

I'd like to read more. Could you please post your source?

Thanks,

Jan


debilitated
Regular Member


Date Joined Jan 2010
Total Posts : 448
   Posted 3/14/2010 2:14 PM (GMT -7)   
Unfort. I can not. The Site is for pharmacology professionals only such as Doctors, medical professional or pharmacists.
I am NOT one of the above but accessed with username and password.

www.factsandcomparisons.com

Any questions regarding side effects... clinical trials or anything.. I can tell you pretty much for ANY drug. Even drug approvals etc..

jan2003
Regular Member


Date Joined Jul 2004
Total Posts : 92
   Posted 3/14/2010 6:14 PM (GMT -7)   

Oh well, that's ok. I have a ton of favorite sites I use to keep up-to-date with new therapies and studies as well; some that require "false" medical credentials :)

I just like to see the actual source/website link, when folks on message boards post information that has been obviously cut and pasted.

I hope the mtx works for you and you can avoid surgery. Good luck!

Jan

 

 


kmfdm
Regular Member


Date Joined Jun 2008
Total Posts : 78
   Posted 3/14/2010 10:31 PM (GMT -7)   
i would like your opinion on Protista, eukaryotic organisms, phyla 27, tryparosomes, dinoflagellates and giardia.  Entamoaeba and anything regarding symbionits.

debilitated
Regular Member


Date Joined Jan 2010
Total Posts : 448
   Posted 3/15/2010 6:58 AM (GMT -7)   
Protista ? is not an FDA approved Drug. Organisms? Multicellular? Can't help u there.
phyla 27 - Same thing

Sorry Kmfdm, dinoflagellates? Marine Toxins?

Not my field up study.. Sorry
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