Will Pantasa work well for crohns throughout the small intestines?

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vid53
Regular Member


Date Joined Jan 2006
Total Posts : 117
   Posted 3/18/2010 8:56 PM (GMT -7)   
I am starting to take Pentasa and just wondering if this drug will break down and work in the small intestines. Has anyone had good luck with this?

Grandpato2
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Date Joined Dec 2009
Total Posts : 681
   Posted 3/18/2010 11:11 PM (GMT -7)   
Pentasa is a 5-asa that is granulated and is released in the upper gastrointestinal tract including the ileum and the colon. It starts treatment right out of the duodeum and treats continually to the anus.
Male, 54 years old with Crohn's since 15 years old, diagnosed at age 46. Terminal ileum resected 2002. 5 months of remission. Crohn's has now been active since early 2003. Had a gall bladder removed Nov. of 2009. Currently on Remicade every 8 weeks, Nexium, Iron, B-12 injection every 4 weeks,5-asa Asacol, Morphine Sulfate as needed for pain. Cymbalta for long term pain control. 5-asa Salofalk, Entecort, Imuran and Prednisone in the past.


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 3/19/2010 6:11 AM (GMT -7)   
Grandpato2 is correct. Pentasa treats Crohns in the small intestine. I use the sister med Asacol and my Crohns has always been at the last part of the small and the beginning of the large intestine. Good luck!
Gail*Nanners* Co-Moderator for Crohns Disease & Anxiety/Panic
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

gumby44
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Date Joined Nov 2007
Total Posts : 4095
   Posted 3/19/2010 6:36 AM (GMT -7)   
Pentasa is designed to release in the small intestine. You won't know if it works well for you until you try it for a few months. I have Crohn's in my small intestine and ileum and it works well for me, but everyone is different. It has few side effects and is worth a try.
51 yr. old female, diagnosed with Crohn's in small intestine and terminal ileum Sept-Oct. 2007. Also have IBS, and had Salmonella Dec. '07
currently taking Pentasa- 4 500mg pills per day, Metamucil and colace for constipation, probiotics


artist guy
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Date Joined Jan 2010
Total Posts : 1373
   Posted 3/19/2010 10:05 AM (GMT -7)   
I have the same as gumby, but with 4 surgeries, 2 resections, pentasa never helped me. I went up to entocort and that didn't work so well, now imuran and pred, just so so. 40 yr's with cd

artist guy


vid53
Regular Member


Date Joined Jan 2006
Total Posts : 117
   Posted 3/19/2010 7:32 PM (GMT -7)   
Thank you for all the replys. Right now the only thing that has worked is prednisone.

beave
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Date Joined Mar 2007
Total Posts : 1091
   Posted 3/21/2010 2:37 PM (GMT -7)   
While it is true that Pentasa is formulated to release throughout the small intestine as well as the large intestine, research has not shown much benefit for Pentasa in small bowel Crohn's disease.  Therefore its use in small bowel Crohn's is debatable/questionable.  Feel free to try it; just don't expect dramatic results.

vid53
Regular Member


Date Joined Jan 2006
Total Posts : 117
   Posted 3/21/2010 5:47 PM (GMT -7)   
What is the best for the small intestines?

Grandpato2
Veteran Member


Date Joined Dec 2009
Total Posts : 681
   Posted 3/21/2010 11:00 PM (GMT -7)   
Continue to use it and see if it helps. Everyone reacts differently to 5 asa's. If pentasa doesn't work there are others of the same class to try.The one's that I know of are called, asacol, lialda and salofalk


Male, 54 years old with Crohn's since 15 years old, diagnosed at age 46. Terminal ileum resected 2002. 5 months of remission. Crohn's has now been active since early 2003. Had a gall bladder removed Nov. of 2009. Currently on Remicade every 8 weeks, Nexium, Iron, B-12 injection every 4 weeks,5-asa Asacol, Morphine Sulfate as needed for pain. Cymbalta for long term pain control. 5-asa Salofalk, Entecort, Imuran and Prednisone in the past.

Post Edited (Grandpato2) : 3/22/2010 12:21:23 AM (GMT-6)


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 3/22/2010 7:16 AM (GMT -7)   
Yes I agree with Granpato2, if this 5asa does not work for you, you can try another. Pentasa always gave me more diarrhea. I now take the sister med Asacol and have been sucessfully maintained on it. Hugs!
Gail*Nanners* Co-Moderator for Crohns Disease & Anxiety/Panic
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

beave
Veteran Member


Date Joined Mar 2007
Total Posts : 1091
   Posted 3/22/2010 11:06 AM (GMT -7)   
As far as I know, *none* of the 5-ASAs has been shown to be effective for small bowel Crohn's.

You'd have to move up to imuran, 6-mp, methotrexate, or one of the biologicals to get a med that has been shown in studies to work.
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