I'm new here and need advice on Cipro

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qwijybo
New Member


Date Joined Mar 2010
Total Posts : 8
   Posted 3/19/2010 6:42 AM (GMT -7)   
I've been a long-time lurker here, but this is my first post, so hello everyone. This forum has really been a great comfort and source of information for me, so thank you.

A little background on me: I was officially diagnosed with Crohn's in 2007, but I have had stomach "issues" (diarrhea, abdominal pain) my entire life, as do most people in my family. The GI that diagnosed me put me on Pentasa, then Keflex (antibiotic), neither of which worked (in fact, the Keflex made my symptoms much worse). He was also very hard to reach, and I felt like I wasn't getting the best care, so I decided to try a new GI.

Since I started seeing her two months ago, I have tried Lialda, Asacol, and Entocort (which I am currently on, with no success). Before the Entocort, she wanted me to try Cipro, but my experience with antibiotics has always been the same: I end up with worse diarrhea than before. My mother was also hospitalized with c. diff a few years ago, which can be caused by taking antibiotics long-term, from what I understand. That was a hellish situation, and I would rather just deal with the Crohn's and not take anything than have to go through that. now that the Entocort has done zilch to help me, she really wants me to try the Cipro.

My new doctor has also recommended that I see a Crohn's specialist, since my disease is "hard to manage." I'm not sure if I should bite the bullet and try the Cipro, even though I am terrified of it, or just take nothing and wait to see the new doctor and get her opinion.

Has anyone here with "hard to manage" Crohn's tried Cipro, and has it worked for you? Has anyone's symptoms been made worse by it?

Thanks for your advice!
Dx with Crohn's in 2007, although my issues have been lifelong.
Previous medications: Pentasa, Keflex, Asacol, and Lialda.
Currently on: Entocort (with no success so far).


debilitated
Regular Member


Date Joined Jan 2010
Total Posts : 448
   Posted 3/19/2010 7:04 AM (GMT -7)   
Welcome to HW. Nice to meet you.
This is just my opinion but Cipro doesn't work great alone. If your going to be in cipro... You add Flagyl/Metrodinazole. The 2 Work well together.

If oral medication isn't working for you, and you really need relief..
You can always Monotherapy on Humira or remicade.

Plenty or even most of our members have been on remicade or humira for years alone. If entocort has no effect, who knows if cipro will do well by itself. Cipro is known to make your stomache feel like crap. HONESTLY, I wouldn't even go for it.... Thats just me. Im not your doctor or you..

good luck,
Male, 22. Diagnosed with Crohn's officially since 2001.. Osteoporosis, Generalized Anxiety Disorder, Chronic Anemia.

Medications Used: Remicade, Humira, Cimzia, 6-mp, Pentasa, Flagyl, Prednisone, Zifaxan, Entocort,
TPN (Total Parenteral Nutrition), The whole nine.

Current: Methotrexate Injection, Entocort EC, Vitamin D, Fentanyl 25mcg / 72hrs - Zofran - Folic Acid
Currently On SSDI


MMMNAVY
Veteran Member


Date Joined Jul 2006
Total Posts : 6927
   Posted 3/19/2010 7:19 AM (GMT -7)   
I would say that your situation is not unusual in that antibodics can make you feel worse, but I actually do feel better on a combo of antibodics, but I also take probodics with it and eat LOTS of yogert.


Forum Co-moderator - Crohn's Disease/Thyroid Disorders:_All comments have the caveat contact your local health care provider.

I will find a way or make one. –Phillip Sidney 1554-1586

All that I am and all that I shall ever be, I owe to my Angel Mother.

The Bucket List- Have you found joy in your life?  Has your life brought joy to others?

Make sure your suffering has meaning…

Post Edited (MMMNAVY) : 3/19/2010 9:29:59 AM (GMT-6)


medchrt1
Veteran Member


Date Joined Sep 2005
Total Posts : 517
   Posted 3/19/2010 7:46 AM (GMT -7)   
..."with no success"...with no success of what? you primarily indicate D. so perhaps just ask for a med for that. docs find inflammation the paramount thing to alleviate in crohns. If you want something to address the D, it appears your present regimen does not have such a med. of course if there is some sort of bacteria contributing to your D, then antibioics are used to treat bacterial infections , albeit have the side effect of D. Then when you ask your doctor to alleviate the D and they say try cipro and you get more D then you can say back to the doc after trying it, that cipro didnt work to solve my D issue.

gypsyfp
Regular Member


Date Joined Jan 2010
Total Posts : 336
   Posted 3/19/2010 8:27 AM (GMT -7)   
I've been on Cipro/Flagyl three times and I never had extra diarrhea because of it.
I've never taken cipro by itself. I have taken Flagyl by itself. Man, it gives me the worst after taste ever! It makes food taste like metal and water taste like poison.
But I have to admit, cipro/flagyl, when i took it the third time, did the most good for my fistula. It stopped draining and sealed over, but it's still there.
I don't want to take them anymore because I don't want to get c-diff.
Diagnosed with typical Crohn's at 16.
Got lucky with Asacol for a year, then even luckier with ten years of relative remission.
Now abscesses and fistulas are having an "atypical" Crohn's party around my junk.
My HMO refused the Remicade and now I could be going on Lialda or sulfa? blah


Lioness2001
New Member


Date Joined Aug 2008
Total Posts : 12
   Posted 3/19/2010 8:43 AM (GMT -7)   
Cipro/flagyl worked very well for my diverticulitis and I had no side effects except for a bad taste from the Flagyl.
 

sr5599
Veteran Member


Date Joined Aug 2007
Total Posts : 1202
   Posted 3/19/2010 9:05 AM (GMT -7)   
I took Cipro with Flagyl last spring and ended up in the hospital. Of course the docs don't point to the antibiotics, but it was clear to me. I started the two antibiotics and within a week the D was worse. It continued to get worse and worse. I kept calling my doctors (GI and primary, anyone who would listen) and finally quit them both and checked myself into the hospital (certain I had c-diff, which I didn't) after I lost control within literal seconds of when the urge hit. I was crossing the street from my neighbors house to mine and could NOT control it to even get across the street. Bam! My temps were up to 102.5 and I gave up. I have avoided them since.

Having said that, twice prior I was on either Cipro alone and once a that same combo and I did not get worse D. In fact, it did seem to help me. Cipro along with steroids has an increased likelihood of a ruptured Achilles tendon. So if you do try it, and are still on Endocort, watch for soreness.

Cirpo is commonly used in Crohn's. I don't know how much it helps others though. Some people have better luck with Xifaxan. It's another antibiotic that doesn't seem to give the D or any of the other icky antibiotic effects. Maybe you could ask your doctor about that one. Cipro and Flagyl are the most common, so I won't be surprised if she wants to to try it. Just watch for worsening symptoms and call the doc about stopping.
1 fistula, crohn's colitis, limited to large intestine
Compounded budesonide 3mg/daily, Cimzia, MTX . Dx Osteoporosis 10/08 started Forteo 1/27/09


qwijybo
New Member


Date Joined Mar 2010
Total Posts : 8
   Posted 3/20/2010 8:40 AM (GMT -7)   
Thanks everyone for your input.

I told my doctor (who called me on a Saturday... how awesome is she?) that I was terrified of the antibiotics, and she is going to put me on Prednisone. I know the side effects can be nasty, but hopefully it will put me in remission and I won't have to take it long.
Dx with Crohn's in 2007, although my issues have been lifelong.
Previous medications: Pentasa, Keflex, Asacol, and Lialda.
Currently on: Entocort (with no success so far).


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 3/20/2010 8:44 AM (GMT -7)   
I took Cipro one time for a Small Intestine Bacterial Overgrowth, and it worked really well for me without side effects at all. Then I had to take again about a month ago and only made it 4 days because it made me so sick with nausea and diarrhea. Crazy how it worked well one time, and not the other. I know that Pred is a med we love to hate, but it works the fastest for me to quiet a flare down. Hope it helps you to feel better. Hugs!
Gail*Nanners* Co-Moderator for Crohns Disease & Anxiety/Panic
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

CrazyHarry
Veteran Member


Date Joined Mar 2006
Total Posts : 1034
   Posted 3/20/2010 9:00 PM (GMT -7)   
dont take it. it can cause peripheral neuropathy (ie tingling) which can go away when you stop taking it, but in some cases is permanent. it is the class of fluoroquinolone antibiotics, which should have a black box label. truly gnarly stuff.
Crazy Harry

---------------------------------------------
Crohn's since 1993 (17 yrs old then)
surgery in July '05 - removal of 2 inches at ileum and 8 inches of sigmoid colon (had fistula into bladder)
Nov '05 developed colonic inertia; July '06 told i needed ostomy surgery
began maker's diet in August '06 - now feeling the best ever with no symptoms of colonic inertia and i kept my colon
med free as of 10/31/07


Mikeyy88
New Member


Date Joined Mar 2010
Total Posts : 1
   Posted 3/21/2010 12:20 AM (GMT -7)   
I just finished taking my cipro/flagyl combo and boy, did it take a toll on me! I had D the entire time I was on it probably twice as bad as I did before. But, it did make the infection in my illeum go away so I was happy about that. Today I started my first Crohn's regimen of 6MP, Endocort, and 25mg Prednisone. It's 3:18 am and my heart is popping out of my chest! I feel so tired yet my pulse is 155bpm so for tonight, I am screwed. Thank god its saturday and I am off tomorrow.

Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 3/21/2010 8:20 AM (GMT -7)   
Mikey big hugs to you!  Are you taking your steroids as early in the morning as possible?  Thats what I do, and it helps to avoid some of the insomnia and other unpleasant side effects.  If you are feeling its interferring too much with your sleep, do talk to your doc about something to help out there.  Hugs!
Gail*Nanners* Co-Moderator for Crohns Disease & Anxiety/Panic
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

crohnielass
Veteran Member


Date Joined Mar 2009
Total Posts : 1118
   Posted 3/21/2010 10:09 AM (GMT -7)   
Hi and welcome! I too am going on to cipro, Had Fagyl in the past but it was awful to many side effects, the GI said to try cipro as its not as bad as Flagyl just got to get the op out of the way first! Bev x
Diagnosed with crohns at 13 now 43
Reversal of temp ileostomy finally have a date 7th April 2010
Meds: Iron syrup,Loperimide,Folic acid & Citalopram 60mg (for Anxiety.)


" I may not be there yet, but I'm closer than I was yesterday."


Tara28
Regular Member


Date Joined Apr 2005
Total Posts : 362
   Posted 3/22/2010 4:13 PM (GMT -7)   
Just wanted to add my 2 cents about the Cipro. I was on it for 4 years straight.
 
The one thing they don't tell you? Watch your caffeine!! Cipro severely inhibits caffeine from leaving yoour body, so after awhile you have toxic doses in your system. I started having major panic attacks and racing heart, I thought I was going to die. I have now been off cipro for 3 yrs and still very very sensitive to caffeine (usually buy decaf k cups) .. I used to be to the type to have 6 cups a day and no effect.
 
Other than that its far less scary than pred, if it was between cipro and pred I would take cipro everytime.
Cipro is usually paired with flagyl as cipro works on the aerobic bacteria and the flagyl works on the anaerobic. so they work well together.
30 years old, dx with Crohn's in 1998. Currently on Imuran 100mg/day, Flagyl 1000mg/day
and Cipralex 10mg/day for anxiety. Just got off Cipro which was my drug for last 4 years.
Perianal fistula, and 2 more suspected. Crohn's only at end of colon, cecum. Remi and asacol did NADA.


njmom
Veteran Member


Date Joined Apr 2006
Total Posts : 1884
   Posted 3/22/2010 4:21 PM (GMT -7)   
My daughter got fever of 103.6 degrees Fahrenheit from Cipro.  After two days and nights of battling to keep fever rising no higher than that, I noticed the connection between the fever rise and fall and the administration of Cipro (every 12 hrs). Pointed it out to the docs in the hospital so they withdrew it and the fever went away.

Becky77
Veteran Member


Date Joined Dec 2005
Total Posts : 1768
   Posted 3/22/2010 4:27 PM (GMT -7)   
I just wanted to add that my personal opinion is that crohn's itself is a "hard to manage" disease because each of us is different, and our typical is very erratic and unpredictable.

If you can, I'd suggest going to a crohn's specialist. My GI specializes in crohn's and she is wonderful!
Becky

32 yr old female-dx with Crohn's in '97 after emergency resection and appendectomy, 2nd resection '05, Bilateral pulmonary emboli 10/09
Currently on Humira, Omeprazole, Effexor, Seroquel, Calcium, Vit D, Coumadin


gumby44
Veteran Member


Date Joined Nov 2007
Total Posts : 4100
   Posted 3/22/2010 4:31 PM (GMT -7)   
Cipro has helped me more than once when Prednisone did not. Everyone is different, but it's definitely worth a try
51 yr. old female, diagnosed with Crohn's in small intestine and terminal ileum Sept-Oct. 2007. Also have IBS, and had Salmonella Dec. '07
currently taking Pentasa- 4 500mg pills per day, Metamucil and colace for constipation, probiotics

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