Any GOOD results with Humira??

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Christine1946
Veteran Member


Date Joined Aug 2008
Total Posts : 5856
   Posted 3/20/2010 4:06 AM (GMT -7)   
     I have ulcerative proctitis.  After only three infusions of Remicade, it failed and I am starting Humira on Wednesday.
     I just read all the posts pertaining to all the neuropathy damage and other bad side effects of the Humira.  Must admit...PRETTY SCARYYYYYY STUFF!  This is my last straw before seriously considering surgery.  Now not so sure that I just shouldn't have chucked the Humira and gone right to surgery.  However, reading about people who have had the surgery, it isn't all it's cracked up to be either.  A lot of complications and emptying their bags eight times a day..whew.  I don't even "go" that many times a day and I sleep through the night without getting up.
     It's just that I have become prednisone dependent and it has done enough damage to me....osteoporosis, high blood pressure and now  my 2 hr pp blood glucose is highrolleyes .
     Please, someone write they have had good results with Humira!!!!!
 
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008 for ten days.
Remission Nov 08 thru May of 09.
Flare May of 09 thru Aug of 09.  Very short remission.  Flared again Nov 1st.  Started Remicade Nov 18th.  Felt great after first two infusions.  Suffered a set back after 3rd infusion on Dec 31st. 
But suffered thru a 4th infusion...nada.  Starting Humira Mar 24th.


Wolfie40
Veteran Member


Date Joined Dec 2008
Total Posts : 947
   Posted 3/20/2010 5:39 AM (GMT -7)   
Well, knock on wood I have been on it since Jan 2010 and I feell okay, i don't have any pain at all. i will be able to tell you more at the end of the year when I have another scope. I too was scared to go on any medication harder than Asacol
But when they said my disease was back 10 months after surgery, I said enough is enough and did it. I also looked at all of the side effects Humira could cause and was terrified but I had to weigh the Pro's and Con's and the Pro's won.
If you were on Remicade, the side effects should be very similar to those of Humira. If so I wouldn't worry.
Good luck with your decision.
Diagnosed with Crohns in 2001
First and hopefully last Ileocecectomy 2/18/2009

Medications:Humira,  Asacol, FolicAcid,  Multivitamin, 1000mg Calcium, Vitamin D, Probiotics, Pepcid Complete, Questran,  Monthly B-12 injections.

Living a Great life with my Wife and my two Chocolate Labs
Hunter & Hailey.
I love them dearly.


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 3/20/2010 8:47 AM (GMT -7)   
Many folks have had success with Humira when the Remicade failed. If you read the side effects on Tylenol you would be afraid of taking that. Give it a shot, maybe it will help you to start feeling better. Hugs!
Gail*Nanners* Co-Moderator for Crohns Disease & Anxiety/Panic
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Christine1946
Veteran Member


Date Joined Aug 2008
Total Posts : 5856
   Posted 3/20/2010 1:21 PM (GMT -7)   
     Thank you Nanners and Wolfie!!!!  I had no side effects from the Remicade.  The doctor only had me on half the max dose.  Two days after my 3rd infusion I suffered a virus....diarrhea, body aches, nausea, temp of 101.  It only lasted 24 hrs, so therefore, I believe it was a bug.  The GI doctor thought it may have been serum sickness but what I read about serum sickness did not correlate to my symptoms.  I did have a 4th infusion , did not suffer from any type of virus, but it had no effect...still had UP symptoms.
 
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008 for ten days.
Remission Nov 08 thru May of 09.
Flare May of 09 thru Aug of 09.  Very short remission.  Flared again Nov 1st.  Started Remicade Nov 18th.  Felt great after first two infusions.  Suffered a set back after 3rd infusion on Dec 31st. 
But suffered thru a 4th infusion...nada.  Starting Humira Mar 24th.


soppendeuff
Regular Member


Date Joined Jun 2008
Total Posts : 27
   Posted 3/20/2010 1:50 PM (GMT -7)   
Humira has helped me a lot. The side effects have been almost non-existent - so far not nearly as many respiratory infections as I used to get on the Remicade (started Humira in Nov. 09).

The only worry has been rashes and later scarring at the injection site. I'm apparently allergic to the liquid solution that the Humira lives in. So now, I ice for 30 minutes before and after the injection and takes loads of anthistamines for a couple of days before and after the shot. Works like a charm.

Best of luck with your decision.

ivy6
Elite Member


Date Joined Sep 2005
Total Posts : 10404
   Posted 3/20/2010 3:01 PM (GMT -7)   
Christine, are you sure your doc has given the Remicade a fair try? There is a blood test by which you can see if you have developed antibodies to the Rem, and it might be worth having that before making the switch to Humira. Also, if you're on less than the standard dose and have only had four injections... well, it just doesn't seem to me as if s/he's given it enough time to really start working.

There aren't *that* many meds for Crohn's. You don't want to lose some unnecessarily: what happens if you need another big gun in the future?

As far as Humira goes, it has (so far) brought me from the point of needing an ostomy, to a remission I didn't think was possible. I'm still having gut symptoms, but not full-blown Crohn's.

I'd suggest being optimistic. YOu may get amazing results too.

Ivy.
Co-Moderator Crohn's Forum.

Medications for Crohn's ~~ Diet and Nutritional Therapy for Crohn's ~~ Dealing with Abscesses and Fistulae ~~


Aimee =)
Veteran Member


Date Joined Jun 2004
Total Posts : 1020
   Posted 3/20/2010 7:27 PM (GMT -7)   
I had great success on Humira - used it for 2 years and was symptom free. My only side effect was some hair loss (nothing noticeable to anyone but my drain!). Remember that all drugs have scary potential side effects and you have to weigh your quality of life and the very rare risks and make the best decision you can.

Ultimately, Humira stopped working and Cimzia never did work so I had surgery. It's not a "fix" - and I may be right back on similar drugs in the near future. Surgery removed the current issues and seems to be putting me into remission but it won't last forever and I still need meds.

Janger84
New Member


Date Joined Mar 2010
Total Posts : 8
   Posted 3/21/2010 7:29 AM (GMT -7)   
i have been on the humira pen everyother week for 2 years now and i dont notice any real side effects other than the occasional respitory infection or cold but that may or may not be from the humira. It has worked really well for me, good luck hope it has the same effect on you

Christine1946
Veteran Member


Date Joined Aug 2008
Total Posts : 5856
   Posted 3/21/2010 12:46 PM (GMT -7)   
     Ivy...I wondered the same thing, if my doctor gave the Remicade a fair shot.  I did ask him in my woozy state of mind, after my flex sig about ten days ago.  He had to put me completely out for that because I have bad rectum inflammation.  He said that since I had great results after the first two infusions that I should not have gone back into a flare so quickly after my third.  Again, after my 4th infusion...nada.  He is one of the head doctors in his practice and over the past eleven years I have seen mostly all of them..lol.  There were four other doctors from his practice at the surgery center where I had my flex sig and they all consulted about my case and came to the agreement not to continue the Remicade.   I don't have Crohn's, I have ulcerative proctitis.  Surgery would by my cure but I don't want to take that major step just yet.
 
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008 for ten days.
Remission Nov 08 thru May of 09.
Flare May of 09 thru Aug of 09.  Very short remission.  Flared again Nov 1st.  Started Remicade Nov 18th.  Felt great after first two infusions.  Suffered a set back after 3rd infusion on Dec 31st. 
But suffered thru a 4th infusion...nada.  Starting Humira Mar 24th.


Thesickone
New Member


Date Joined Mar 2010
Total Posts : 1
   Posted 3/21/2010 8:34 PM (GMT -7)   
I got diagnosed with crohns in dec 2001 got a fistula in 2006 had a colostomy for 2 years was put on humira in aug 2006 after my kidneys shut down and i met the best dr in the world (in my opinion) he put me on humira and been on it since then. i have a lot less pain and less flare ups it is a wonderful thing and i have no side effects and i did with remicade i was on that for a year hope that helped.
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