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ALgirl
Regular Member


Date Joined Mar 2010
Total Posts : 105
   Posted 4/1/2010 9:04 PM (GMT -6)   
Do any of you have this in association with your Crohn's disease?  My doctor thinks that I might have this now.  He is sending me for back x-rays.  Any advice?  I am in so much pain I can barely do anything!!  Has anyone had problems with back pain on Pentasa either?  I am wondering if that could have anything to do with it.  He is sending me for a urinalysis too.  Does Pentasa affect kidney function?  No symptoms of UTI...  Thanks in advance!

Diagnosed w/ Crohn's 2010
Current meds: Pentasa, prednisone taper


PV
Veteran Member


Date Joined May 2006
Total Posts : 1143
   Posted 4/1/2010 9:43 PM (GMT -6)   
Last novemeber, my husband got up one morning and said the inside of his right butt cheek is hurting. Within 2 days he could barely walk, his neck got really stiff, and he knee starting filling up with fluid and getting really swollen. The doc took an x-ray of his back, and said he's got inflammation of the ileo-sacral joint (sacroiliitis). We still don't know for sure what caused that horrid joint inflammation - his neck was so stiff he couldn't turn either way, his knee swelled up like a watermelon every couple of days, and his sacroileal joint was very inflamed. It took going to 40 mgs of pred, a couple of steroid injections to the knee (and repeated draining) and moving his remicade infusion to every 6 weeks instead of 8, to reduce the inflammation and take down the swelling. The rheumatologist thinks it was inflammatory arthritis related to crohn's disease; the GI thinks it was maybe reactive arthritis, caused by a bout with c-diff. Noone knows for sure.

I do believe that crohn's can cause joint pain and inflammation. But what the rheumatologist told me is that Crohn's disease usually causes what are known as sero-negative spondyloarthropathy - a type of inflammation that is painful, but usually takes a long time to do real damage (unlike rheumatoid arthritis). I think if you are having problems with joint pain and inflammation related to crohn's disease, you should see a rheumatologist.

All mesalamine medications (Pentasa is one of them) can affect the kidney - this is usually why doctors regularly check kidney function of patients taking mesalamine. On the whole mesalamine medications are pretty safe, and as long as you are monitored regularly, you will be fine. My husband's GI typically does the blood test for kidney function (I think it's blood creatinine).

If you are having inflammation in your joints, it may not be prudent to continue your prednisone taper. I think you should discuss this with your doc before you continue to taper further. Perhaps add 1 more med to the mix, like methotrexate, imuran or 6-mp, give it some time to reach therapeutic levels, and then try to taper off the pred again.

Take care.

((Hugs))
PV
Husband with Crohn's
Diagnosed March 2003 Ulcerative Proctitis
Diagnosed March 2008 Crohn's & C-diff, hospitalized 45 days
Crohn's in Remission since June 2008
C-diff recurrence Sep 2009
Reactive Arthritis Nov 2009
Currently c-diff free
Osteopenia of spine (Mar 2010)
Canasa (1gm), Lialda (4.8 gms), Remicade (8 weeks)
Currently In Remission


lamb61
Veteran Member


Date Joined Jan 2005
Total Posts : 1540
   Posted 4/2/2010 5:09 AM (GMT -6)   
Unfortunately, this is an on going problem with me and it's compounded by a degeneration between L5 & S1. I do get relief from physical therapy so you might want to ask about that. Also, a heating pad sometimes gives me temporary relief but not much. I doubt the Pentasa is a contributing factor. It's more likely disease activity. Xrays or an MRI would give you a clearer picture of what exactly is going on.
 


lilcrohnieUK
Regular Member


Date Joined Dec 2007
Total Posts : 414
   Posted 4/2/2010 6:18 AM (GMT -6)   
Yup I had this severely before, what got me through was swimming (being in water takes pressure of the joint so provides pain relief, which allows you to move the joint and disperse trapped fluid and strengthen the surrounding tendons and muscles - I used to go twice a day sometimes just because being in the pool was the only time I wouldn't be screaming in pain) and steroid injections into the joint. Theres been a few threads on this which are packed full of advice so might be worth doing a search. Anyhow I really feel for you it is nasty!
 
 


ALgirl
Regular Member


Date Joined Mar 2010
Total Posts : 105
   Posted 4/2/2010 3:50 PM (GMT -6)   
Thank you so much folks!  I went for my x-ray today and I still had barium showing up!  Can you believe that?  I drank it LAST Friday.  I called the dr and the nurse told me to take MOM and if that didn't work an enema, yuck.  My back hurts so much all I can do is lie on a heating pad.

Diagnosed w/ Crohn's 2010
Current meds: Pentasa, prednisone taper


mtgman
Veteran Member


Date Joined Mar 2005
Total Posts : 1285
   Posted 4/2/2010 11:47 PM (GMT -6)   
i've had severe joint/muscle pain on and off for quite a while. GI just had me get another back e ray a few weeks ago- came back fine. sometimes i have no idea what the pain is since i've had about 8 kidney stones as well...it seems like my whole midsection (front and back) hurt like heck then it goes away after a few days...
35 year old male living in AZ.  Diagnosed with Crohns at age of 15.
Currently tapering prednisone (15 mgs) and I've been on 6_MP for 2 months.
In the middle of a bad flare now for 6 months...lost almost 30 lbs.

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