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MoobyDoo
Regular Member


Date Joined Sep 2009
Total Posts : 212
   Posted 4/15/2010 9:32 AM (GMT -7)   
To anyone who has had experience taking 6MP, my daughter has been on it for two months now. No side effects that we have noticed at this point. We just had her bloodwork checked again...the first recheck since starting the med.  While there is some inprovement in her CBC, her CRP has decreased only from 33 to 27.  This is a bit disappointing, but the doc thinks we should give it more time.  Appetite still not great. Still skinny. On the upswing, she has been feeling better...only a few tummy aches here and there which don't last long. Very little D lately. Her energy level seems normal and she's been in a very good mood since she's been feeling so much less pain.
 
Any feedback?  How long before "your" CRP went down?
 
Thanks.

  • lilcrohnieUK
    Regular Member


    Date Joined Dec 2007
    Total Posts : 414
       Posted 4/15/2010 10:51 AM (GMT -7)   
    I'm not on 6MP but am on methotrexate another immunosuppressent. I found my CRP went down slowly, it was probably about 4 months before I was feeling closer to normal - so totally worth the wait though I've been on it 8 years and have had remission periods of up to 3 years (the flares I had during those 8 years were down to the dosage being fiddled with)
     
     


    Nanners
    Elite Member


    Date Joined Apr 2005
    Total Posts : 14995
       Posted 4/15/2010 11:06 AM (GMT -7)   
    6MP can take up to 4-6 months to reach full efficacy. So lilcrohnieUK has pegged it pretty well that by 4-6 mos you should see more change. Good luck!
    Gail*Nanners* Co-Moderator for Crohns Disease & Anxiety/Panic
    Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
    *Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

    Rider Fan
    Veteran Member


    Date Joined May 2008
    Total Posts : 1445
       Posted 4/15/2010 12:17 PM (GMT -7)   
    CRP was never something that's been checked regularly with my so I can't say how long it took. I would give it more time, I know it's hard to stay patient.
    33 y/o male. Dx'ed in 1999. No surgeries.

    Current meds: Humira 2/27/09. Proferrin iron pills.

    Tried SCD, didn't work, now avoiding gluten and dairy.


    Go Saskatchewan Roughriders!


    Zanne
    Veteran Member


    Date Joined Apr 2005
    Total Posts : 3763
       Posted 4/15/2010 12:22 PM (GMT -7)   
    I went back over some of my blood work and I can't see that I have any CRP levels. I don't have a lot of my blood work results, so that's not to say that it is never checked but I can't say how long it takes to go down. But 6MP takes months to reach full effect and even then if you aren't at a therapeutic level you might not be getting the full benefit, so I think you still need to be patient. Since she is showing signs of improvement, I would say you are on the right road though.
    Suzanne

    CD 20 years officially, 30 unofficially. 3 resections '93, '95 '97
    Managing with strict low residue diet, keeping symptoms to a minimum. All test show small amount of ulceration, still have occasional blockages. But still have a great time with my 2 daughters and husband!


    Prednisone, 6MP,Prevacid, B12 shots, Bentyl, Xifaxan.....


    MoobyDoo
    Regular Member


    Date Joined Sep 2009
    Total Posts : 212
       Posted 4/16/2010 8:36 AM (GMT -7)   
    Thanks for all your replies. We will  hang in there with the 6mp for now. Even though her CRP is not dropping quickly, she is def. feeling better.  Seems odd to me tho, that some of you say that you don't know your CRP levels, or that your doc doesn't check or mention it often.  Here, with my daughter, it seems to be THE factor that her GI Doc looks at the most. It is the inflammation marker. He talks about it every single time we see him or communicate with him.  It is his measure of how active or inactive her Crohn's is.  Do I assume this is NOT standard practice for all GI Docs?  Is there some other important marker in the blood work we should be looking at?  (Her albumin is also low, altho only by 1 pt, along with some other things...but still he focuses on the CRP always.)


  • Zanne
    Veteran Member


    Date Joined Apr 2005
    Total Posts : 3763
       Posted 4/16/2010 8:47 AM (GMT -7)   
    I can't answer for anyone else but me. I know that my CRP has been checked, but I don't have copies of all of my blood work, and especially dating back to when I was first diagnosed and trying to find the right treatment. I've had this DD for well over 20 years and I just don't have the paperwork from back them. I also have different doctors than I had then. I do know that my white blood count is monitored, and because of my 6MP my liver panel tests.

    This could be the difference. You have a young daughter, who is still trying to find the right treatment plan, still actively flaring and still growing. Keeping her inflammation down and in check is key to managing her case (I'm guessing here). My doctors are pretty confident that my disease is stable, with minimal activity and they never hesitate to put me through the nasty tests if they feel they want a closer look. I also assume you are seeing a pediatric GI, so perhaps a bit different in their approach.
    Suzanne

    CD 20 years officially, 30 unofficially. 3 resections '93, '95 '97
    Managing with strict low residue diet, keeping symptoms to a minimum. All test show small amount of ulceration, still have occasional blockages. But still have a great time with my 2 daughters and husband!


    Prednisone, 6MP,Prevacid, B12 shots, Bentyl, Xifaxan.....


    misspriss82
    Regular Member


    Date Joined Mar 2008
    Total Posts : 221
       Posted 4/16/2010 3:39 PM (GMT -7)   
    I just started 6-MP a month ago and haven't really noticed anything different.  I am hanging in there, waiting for the meds to work.  I am feeling slightly better, but not to a point where I feel 100% yet.  I have hope that it WILL work for me though! :) 
    28y/o F, diagnosed with Crohn's Disease at 25 y/o , 2000 units of Vitamin D , 1500 Units of Calcium
    60mg of 6-MP once daily since Feb. 2010
     
     


    mirowpl
    Regular Member


    Date Joined Nov 2009
    Total Posts : 380
       Posted 4/19/2010 8:14 PM (GMT -7)   
    2 things. 
    had resection surgery back in Jan.  long recover.  started 6pm 3 weeks ago.  had to stop due to side effect.  GI checked blood work but it was fine. I take other maintance meds and he conferred with my internist. She stopped some others to give the 6mp a better chance.  Started 6mp again.
     
    In 13 yrs, I have never had my GI dr talk about inflamation markers with my blood work. I have most of the copies and it is not a test he runs.  He did a biopsy a long time ago to confirm crohns and has been on meds ever since.  SO, i think it is different with each patient. But is can be useful from what i am told.  In my case 6mp is the last med that i had not tried.Been through all the others along with many combinations. they slowed the disease, for sure, as I went 13 years with no major problems. but it still got me.
     
    hope this helps 
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