CD as an Imune Deficiency - Dr. Behr Video

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Regular Member

Date Joined Dec 2008
Total Posts : 61
   Posted 4/19/2010 9:08 PM (GMT -6)   
Dr. Marcel Behr speaks about Crohn's as an immune deficiency, and Mycobacterium paratuberculosis as a potential pathogen exploiting this deficiency, specifically mutations in the NOD2/CARD15, ATG16L1 and IRGM genes, so as to enjoy a solitary life inside of macrophages found deep within mesenteric lymph nodes, eventually causing lymphangitis leading to mucosal injury.

Post Edited By Moderator (Nanners) : 4/20/2010 7:39:24 AM (GMT-6)

Veteran Member

Date Joined Apr 2006
Total Posts : 1884
   Posted 4/20/2010 4:42 PM (GMT -6)   
EXCELLENT, THANKS. Was up until 2 AM watching the multiple ten minute videos - have to find time to see the rest today.
He does an incredible job of weaving together evidence-based research. I was already aware that recent research suggested Chronies have a weaker immune system, which means traditional meds, mostly immunosuppresants, might be focused on the wrong problem. He discusses such findings and builds a case, step by step, weaving one research study into another. He finds, for instance, that the NOD2 genetic mutation does not mean a defective response to all bacteria, but to particular bacteria.  And then identifies which bacteria.  
He seems fairly humble, admitting the limits of the research done to date, but in my opinion this guy deserves a prize, as the work he has done, especially recently, eclipses the work of the traditional Old Guard, Dr. Present, Hanauer (yes, even Hanauer), et al, who don't seem to have the faintest understanding of what our intestinal flora is doing.  
Daughter (22) Dx'd Crohn's 3/06. Misdiagnosed for two years, including by top pediatric Crohn's specialist as stress. No symptoms for the past three years. March '09 colonoscopy showed stricture gone but two spots of inflammation in TI. Used LDN to taper off Entocort last fall. (Was on Entocort since April 06.) Never had D. 4.5 mg LDN, SCD multivit, homemade yogurt, 5000IU vit D3, 1000 mg calcium, 27-54 mg iron, monthly B12 shots, daily oral B12 1000, 10mg zinc. SCD diet modified years ago to include potatoes and rice. 

Regular Member

Date Joined Jan 2009
Total Posts : 45
   Posted 4/20/2010 11:11 PM (GMT -6)   
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