Breastfeeding, Mesalamine, and Reye's Syndrome

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kshelef
New Member


Date Joined Apr 2010
Total Posts : 2
   Posted 4/24/2010 10:40 AM (GMT -7)   
Hi,

I'm 30 weeks pregnant for the first time, have CD, and would really like to breastfeed. I've been on Pentasa (4g/day) for a couple of years now to keep the CD under control. I've been talking with my GI and future pediatrician about breastfeeding on Pentasa, but they are concerned about the possibility of Reye's syndrome if our baby gets a viral infection, because mesalamine is a 5-ASA. In other words, mesalamine is chemically very similar to aspirin, which you are definitely not supposed to give to babies. Has anyone else dealt with this concern? For those of you who have breastfed while taking mesalamine, what did your doctors say about the possibility of Reye's syndrome? Or has anyone changed medications from mesalamine to something else in order to breastfeed, and if so, which medication?

Thank you SO much in advance for your help!

Stef17
Veteran Member


Date Joined Feb 2003
Total Posts : 1811
   Posted 4/24/2010 3:09 PM (GMT -7)   
Congrats on your pregnancy! You're almost there!  If you read this link: http://neonatal.ttuhsc.edu/discus/messages/53/877.html?1262908994 you will see what studies have been done on mesalamine and mothers' milk. From what I read it doesn't seem that your baby would be at any greater risk for Reye's syndrome. Dr. Hale says most children who got it were 11-13 years old, no infants had it.
 
I took Asacol (5-ASA) while breastfeeding all 3 of my children and none of them have had any problems with Reyes or even GI symptoms. I was on 1600mg 2x's/day.
 
Hope this helps you a bit. I know what a big decision it is. From what the data shows, it sounds like you can breastfeed without any problem. Let me know if I can help you with any other info.
 
Stef

inflamed
Veteran Member


Date Joined Nov 2005
Total Posts : 1340
   Posted 4/25/2010 12:18 PM (GMT -7)   
I breastfed my daughter 15+ months no problem on Pentasa. I wasn't on the full dose, but there was no concern either way. I'm expecting #2 two weeks before you. I will breast feed on Pentasa again (I'm taking less now though). Read the Dr. Hale link from Stef. My ped, GI, and Lactation Consultants all did their research and agreed it was safe. The one week I stopped taking it, I had a CD accident. I was fine when I stayed on it and so was my daughter. If you are really concerned, time your dose. After a month my daughter would do decent stretches at night, so I would take a dose then. If it would make you more comfortable, you can have your spouse give one bottle at night to give you a longer stretch of sleep w/o feeding and time for the meds to go through. I pumped every morning, but one bottle of formula doesn't hurt either. The bonus with this is extra sleep and you can blame caution about the med. ;)

Congrats on your pregnancy. Do what you have to do to both take care of yourself and breastfeed. Both are important post partum. I really think breastfeeding helped regulate the hormones to keep me from having a post partum flare. It's also just a great experience.
Mom to a healthy Pentasa baby and pregnant with #2. 5+ years remission, woo hoo!


inflamed
Veteran Member


Date Joined Nov 2005
Total Posts : 1340
   Posted 4/25/2010 12:18 PM (GMT -7)   
I breastfed my daughter 15+ months no problem on Pentasa. I wasn't on the full dose, but there was no concern either way. I'm expecting #2 two weeks before you. I will breast feed on Pentasa again (I'm taking less now though). Read the Dr. Hale link from Stef. My ped, GI, and Lactation Consultants all did their research and agreed it was safe. The one week I stopped taking it, I had a CD accident. I was fine when I stayed on it and so was my daughter. If you are really concerned, time your dose. After a month my daughter would do decent stretches at night, so I would take a dose then. If it would make you more comfortable, you can have your spouse give one bottle at night to give you a longer stretch of sleep w/o feeding and time for the meds to go through. I pumped every morning, but one bottle of formula doesn't hurt either. The bonus with this is extra sleep and you can blame caution about the med. ;)

Congrats on your pregnancy. Do what you have to do to both take care of yourself and breastfeed. Both are important post partum. I really think breastfeeding helped regulate the hormones to keep me from having a post partum flare. It's also just a great experience.
Mom to a healthy Pentasa baby and pregnant with #2. 5+ years remission, woo hoo!


sgirl
Regular Member


Date Joined Jul 2009
Total Posts : 417
   Posted 4/25/2010 3:15 PM (GMT -7)   
ditto with stef and inflamed. All our dr's were fine with it and so was I. after i was dx with crohns my gi put me on imuran too as well as pentasa (was an lialda before) and I had to stop breastfeeding because of the imuran, but if I felt ok with it I could have taken it at night and dumped first morning milk. you could do something similar if you're concerned.
Diagnosed with UC in February 2009.
Diagnosed with Crohn's Colitis December 2009.
Flaring since October 2008
Possible Rheumatoid Arthritis

Medication: Pentasa 6x daily, Imuran 50 mg, multivitamin, Vit B12 1 g, omeprazole. Sulfasalazine

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