PPAR-Gamma, Diabetes Drugs, conjugated linoleic acid (CLA)

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Veteran Member

Date Joined May 2009
Total Posts : 703
   Posted 4/28/2010 2:18 AM (GMT -6)   
All new to me.
Somebody said...
Using drugs or diet to boost a protein [PPAR-gamma] to restore the body's natural defenses to gut infections may offer a new way to treat currently incurable bowel diseases such as Crohn's disease, European scientists said on Monday.


GlaxoSmithKline's diabetes drug Avandia, known generically as rosiglitazone, has been shown to restore gut defenses through PPAR-gamma activation.


Samples taken from the colons of humans diagnosed with Crohn's disease also show reduced levels of the antimicrobial peptides, or defenses, regulated by the PPAR-gamma protein, they wrote.

Chamaillard said foods or diets containing conjugated linoleic acid (CLA) can also boost PPAR-gamma activity and have been shown to improve colitis and colitis-associated cancer.

CLA is primarily found in milk and meat products.

Cimzia, Asacol

New Member

Date Joined Feb 2012
Total Posts : 1
   Posted 2/9/2012 1:02 PM (GMT -6)   
I don't think that's 100% true. It might help a bit, but I don't think it's the cure to these diseases. I don't believe that much in chemicals, I think the answer must be in the natural world.
Let's say for example, Avandia has been taken off the market, avandia used to be one of the most important diabetes drugs then they discovered it caused too many side effects. Here's one of the reasons why natural is better - http://www.sucanondiabetes.com/what-is-a-nutraceutical/
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