I developed antibodies maybe 6 months in and had to increase the frequency of the dosage. That maybe helped for a few months and then I could tell it wasn't working very well. A year in, I started having allergic reactions and stopped taking it.
Crohn's Disease, Acid Reflux/Gastritis, Hashimoto's Thyroiditis, Endometriosis, Arthritis, Depression/Anxiety. Too many meds to list them all. =)