How do you know when Humira is no longer working?

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

JAB
Regular Member


Date Joined Nov 2003
Total Posts : 351
   Posted 5/24/2010 9:07 AM (GMT -7)   
Hi Everyone!
So last fall I was officially prescribed Humira. I tell you for first several months it was the wonder drug. To put it simply, I had my life back. It took care of a fistula that I had and calmed the inflammation in my gut. My menu increased dramatically and I was happy to oblige.
 
With in the last couple months I've noticed the occasional bloating when larger meals are eaten. I've also had D on a regular basis. I suspect that either the inflammation is back or I've got some blockage due to scar material. Initially the Humira took care of this but now I think it's back.
 
Last Friday I actually had a fever with severe chills kick in. It dissipated by the next day but it was pretty debilitating for about 24 hours. Last night I had night sweats to an extreme.
 
Needless to say I've got an appointment for  CT Enterography and C DIFF and eventually a scope. Fun Stuff.
I have to say that my gut does feel inflammed but it's not like the medicine has totally run it's course because I would be doubled over in pain.
 
Before the fever the doctor was considering upping the dosage since I only take 1 shot every other week. If the fever has something to do with my body fighting the Humira I don't see why it would be good to increase the dosage.
 
Just wondering what everyone else's thoughts were on whether the Humira was losing it's effectiveness or whether my body was finally identifying the Humira as a foreign agent and creating antibodies.
 
The good thing is that I still eat a fairly decent list of plain items...before Humira I was allocated to tunafish and soup. 
 
No more tacos. cry
 
Thanks for your input.
 
JAB 

Rider Fan
Veteran Member


Date Joined May 2008
Total Posts : 1445
   Posted 5/24/2010 11:04 AM (GMT -7)   
I'm not sure if there is an actual test to see if you have antibodies to Humira. Good question.

Many people find that they need to take a shot every week to maintain remission...
33 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. Proferrin iron pills.

Reduced gluten and dairy.


Go Saskatchewan Roughriders!


Homeboy
Veteran Member


Date Joined Dec 2005
Total Posts : 637
   Posted 5/24/2010 11:16 AM (GMT -7)   
Every week here, maybe 2-3 weeks now at this dose, started in Aug 2009.

ZenaWP
Veteran Member


Date Joined Aug 2007
Total Posts : 884
   Posted 5/24/2010 12:20 PM (GMT -7)   
I don't understand everyone else getting Humira weekly, as both my GI and rheumy said they can't get it approved more than once every 2 weeks.  I thought I noticed the Humira not being as effective after about a year and it's just because I noticed more stomach pains on a daily basis and had to take a lot more stomach spasm medicine.  I switched to Cimzia (which they also can't get approved more than what is recommended, even though other people are getting it more), but it seems I'm flaring now, so I guess I'll switch back to Humira and see if it will work.  Seems most meds work for about a year for me and then I have to switch it up. 
Crohn's Disease, Acid Reflux/Gastritis, Hashimoto's Thyroiditis, Endometriosis, Arthritis, Depression/Anxiety.  Too many meds to list them all.  =) 


JAB
Regular Member


Date Joined Nov 2003
Total Posts : 351
   Posted 5/24/2010 12:49 PM (GMT -7)   

Thank all for the response. Rider I'm under the impression that you are weekly as well? I think I've heard, more then not, that people tend to find remission with weekly shots as opposed to the bi-weekly.  I hope that this is just the case. I didn't know that there was an issue with getting covered for weekly shots. My doctor indicated that we might up the doseage to weekly which sounds like he has done it before in other cases. Hmmmmm.

Homeboy, what happened that the increased dosage was deemed necessary?

 

 

Thanks again for any insight.

 

JAB


Post Edited (JAB) : 5/24/2010 1:52:59 PM (GMT-6)


Ne Ne
Regular Member


Date Joined Apr 2008
Total Posts : 243
   Posted 5/24/2010 1:10 PM (GMT -7)   
I take weekly shots, it keeps everything stable. I took bi-weekly for three or four months and noticed I could feel the shot wear off. I've been on it for two years now. I still get a few small flairs, but for the most part I don't want to go off, and start back up with everything (pain, blotting, D, ....)



Dawn turn yeah
49 Female
Dx June 07 Crohn's take asacol 2x3 a day ,lotrel for HBP , omeprezole for stomach , potassium , calcium & Vit D , lomotil for lose stools , tramadol for pain , started humira in Feb 08 on 1 shot a week, vit-B 12 shots , crestor,off crestor,now pravastatin, pristiq, abilify,
Dx Bipolar May 08


Homeboy
Veteran Member


Date Joined Dec 2005
Total Posts : 637
   Posted 5/24/2010 3:37 PM (GMT -7)   
I just noticed it was not really working.  I am not real sure if it is working now at once a week, but it does seem to be doing something.
 
I get Humira directly from the company, all my g.i had to do was write me a prescription for once a week, and I faxed that to the folks at Humira.  The next week, fedex showed up with my shipment.

ivy6
Elite Member


Date Joined Sep 2005
Total Posts : 10404
   Posted 5/24/2010 3:41 PM (GMT -7)   
Would it be possible to "support" yourself with another med, like Methotrexate or Imuran or pred, to boost the effectiveness of the Humira? Or are you on those meds already?
Co-Moderator Crohn's Forum.

Medications for Crohn's ~~ Diet and Nutritional Therapy for Crohn's ~~ Dealing with Abscesses and Fistulae ~~


Rider Fan
Veteran Member


Date Joined May 2008
Total Posts : 1445
   Posted 5/24/2010 5:09 PM (GMT -7)   
I do bi-weekly JAB. But my GI said he wouldn't hesitate to get me on weekly if I needed it. I also know someone personally who's done weekly shots for years.
33 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. Proferrin iron pills.

Reduced gluten and dairy.


Go Saskatchewan Roughriders!


JAB
Regular Member


Date Joined Nov 2003
Total Posts : 351
   Posted 5/25/2010 4:02 PM (GMT -7)   
Thanks again for the replies.
Right now I'm getting ready to go have an xray done of my abdomen to see if I have blockage. I'm pretty sure I do. The doc did some bloodwork the other day and noted that my iron was low so he put me on an iron supp. (ferrex?). Started and stopped the supplement yesterday. Serious constipation...had to call off work today. I don't remember the last time I had that much pain. I was throwing up as well. Not good.

I'm so depressed right now.
Sorry I just had to put into words the way I feel right now. This disease is so taxing I can't take it sometimes. I was on a peak with the Humira and now I'm right back in the valley of the toilet. cry

I consider myself pretty tough considering what I've been thru over the last 12 years but I find myself breaking down more often lately. I just want to find that peak again.

Anyway, time to go. Ivy I think the doc wants to combo me up with Imuran. Of course if we find blockage that could lead me down another wonderful path. Ugh.

John

JAB
New Topic Post Reply Printable Version
Forum Information
Currently it is Saturday, December 10, 2016 3:33 PM (GMT -7)
There are a total of 2,736,058 posts in 301,351 threads.
View Active Threads


Who's Online
This forum has 151448 registered members. Please welcome our newest member, Twingirldc.
305 Guest(s), 12 Registered Member(s) are currently online.  Details
imagardener2, Dsimms, NM12, Michael_T, astroman, Atomium7, jdm99, Twingirldc, ks1905, joavila92, Poppie, lapilot


Follow HealingWell.com on Facebook  Follow HealingWell.com on Twitter  Follow HealingWell.com on Pinterest
Advertisement
Advertisement

©1996-2016 HealingWell.com LLC  All rights reserved.

Advertise | Privacy Policy & Disclaimer