Medication Alert Proton Pump Inhibitors at risk for women.

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Grandpato2
Veteran Member


Date Joined Dec 2009
Total Posts : 681
   Posted 5/26/2010 11:18 PM (GMT -7)   
 Proton pump inhibitors --  These include dexlansoprazole (Dexilant), esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec, Zegerid), pantoprazole (Protonix) and rabeprazole (Aciphex) are linked in 2 new studies of women to cause an increased risk of fractures and a greater than 70%increase in the risk of infection from C. difficile. It has been reported today by Canada's Global National TV that these studies were published this week by the Journal Archives of Internal Medicine.
 Again just as we get a drug that works really well we now have serious complications to consider while using them. Men pay attention just because only women were considered in these studies as best as I can tell, no doubt we'll be at risk as well. Sorry for having to passing on this information. I'm on Nexium and have been for over a year at least. Rob


Male, 54 years old with Crohn's since 15 years old, diagnosed at age 46. Terminal ileum resected 2002. 5 months of remission. Crohn's has now been active since early 2003. Had a gall bladder removed Nov. of 2009. Currently on Remicade every 8 weeks, Nexium, Iron, B-12 injection every 4 weeks,5-asa Asacol, Morphine Sulfate as needed for pain. Cymbalta for long term pain control. 5-asa Salofalk, Entecort, Imuran and Prednisone in the past.


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 5/27/2010 6:11 AM (GMT -7)   
Well then I am going to have broken bones, because I am not stopping my PPI's. I would be too miserable without them. I will just continue taking my extra calcium and Vit D to protect my bones. JMHO
Gail*Nanners* Co-Moderator for Crohns Disease 
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

ronyan
New Member


Date Joined Nov 2006
Total Posts : 14
   Posted 5/27/2010 7:18 AM (GMT -7)   
I'm a young man age 23 with osteoporosis. I was on PPI's for 5+ years after my diagnosis of Crohn's in 2003. Personally, I think that these drugs have played a role in worsening the condition of my bones. I have a complicated history so I figure it's a combination of different factors. Now I'm wondering if it might be better for me to just get surgery for my hiatal hernia and stay away from PPI's as much as possible.

lamb61
Veteran Member


Date Joined Jan 2005
Total Posts : 1718
   Posted 5/27/2010 7:40 AM (GMT -7)   
I guess I'll be asking my PCP for a dexa scan soon. I've been on Nexium for 4 years now.

Sigh.....
 


beave
Veteran Member


Date Joined Mar 2007
Total Posts : 1091
   Posted 5/27/2010 11:25 AM (GMT -7)   
I think the media is blowing this out of proportion.

Yes, the study showed an increase fracture risk with long-term or high-dose use of PPIs, but the increase in risk was *small*, and that's getting overlooked in all the hysteria.

The C diff risk increase, while much greater, applies to hospitalized patients, so that is of much more concern - but for a limited number of people.

As with any med, there are potential side effects, and it's a cost/benefit decision to be made between the patient and doctor.

Becky77
Veteran Member


Date Joined Dec 2005
Total Posts : 1768
   Posted 5/27/2010 2:26 PM (GMT -7)   
I agree with Nanners...I'd be miserable without them. I've had a DEXA and will continue my Vit D and calcuim!
Becky

32 yr old female-dx with Crohn's in '97 after emergency resection and appendectomy, 2nd resection '05, Bilateral pulmonary emboli 10/09
Currently on Humira, Omeprazole, Effexor, Seroquel, Calcium, Vit D
Coumadin stopped 3/15/10!!!!


spookyh
Veteran Member


Date Joined Oct 2008
Total Posts : 1342
   Posted 5/27/2010 4:29 PM (GMT -7)   
I was anxious to get off Protonix since it can cause a bacterial overgrowth in the stomach and small intestine. Since it's bad for bones, I'm doubly glad I'm off it. I have osteoporosis in my hips, and don't need to make it worse.
35 years old, Crohn's disease for 15 of them
Resection of ileocecal valve on 09/22/09
Current Meds: LDN, Pentasa, Effexor XR
Supplements: 3 kinds of Fish Oil, Multi-Vitamin, Vitamin D, Calcium, CoQ10, Enzymes
SCD since 12/01/08 - eating Stage 3 foods


spookyh
Veteran Member


Date Joined Oct 2008
Total Posts : 1342
   Posted 5/27/2010 8:36 PM (GMT -7)   
beave said...
I think the media is blowing this out of proportion.

Yes, the study showed an increase fracture risk with long-term or high-dose use of PPIs, but the increase in risk was *small*, and that's getting overlooked in all the hysteria.

The C diff risk increase, while much greater, applies to hospitalized patients, so that is of much more concern - but for a limited number of people.

As with any med, there are potential side effects, and it's a cost/benefit decision to be made between the patient and doctor.


They say C diff is becoming much more widespread now, partly due to hospital workers wearing their work clothes/scrubs when they go out to lunch, go to the grocery store after work, etc. What they use to wipe down eating areas in eating joints isn't enough to kill C diff. Here's a link to one article about it: http://online.wsj.com/article/SB123137245971962641.html

Also, you can get C diff any time you take antibiotics. See http://www.cdiffsupport.com/aboutcdiff.html
35 years old, Crohn's disease for 15 of them
Resection of ileocecal valve on 09/22/09
Current Meds: LDN, Pentasa, Effexor XR
Supplements: 3 kinds of Fish Oil, Multi-Vitamin, Vitamin D, Calcium, CoQ10, Enzymes
SCD since 12/01/08 - eating Stage 3 foods

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