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medieval_peasant
Regular Member


Date Joined Mar 2009
Total Posts : 52
   Posted 6/3/2010 6:26 PM (GMT -7)   
Is there anyone on the forum who has failed Humira and had to go on Natalizumab?
25 year old 
college student trying to get a degree in philosophy
Diagnosed Jan. 2008 with Crohns disease.  Been on solumedrol, flagyl, Pentasa, Rowasa, Prednisone, Humira.
 
Currently on Pentasa and Humira.  Started Humira 4-8-10.
 


sr5599
Veteran Member


Date Joined Aug 2007
Total Posts : 1202
   Posted 6/4/2010 11:50 AM (GMT -7)   
I was on Tysabri for 6 months after failing Remicade and Humira. I did have a response, but I was nervous about the risk (being a single mom) and was having a hard time stopping the steroids I was taking when I started Tysabri. The TOUCH program will not allow a patient to continue on steroids beyond 3 months (I think it was). So, I made the choice to discontinue Tysabri. Ironically, I am starting to re-consider and asked my GI's office yesterday if they would prescribe it. If my MTX doesn't kick in by the 6 month marker (1.5-2 months from now) I might just drop them all and try Tysabri again.

I always felt like the risk was carried later on in the therapy, not within the first few months (to see if I even responded to the drug). They are dropping the risk of PML from 1/1000 to something like 7/10,000 now. (I got that from a CCFA webcast on weighing the risk vs benefit of the medications. It's still posted on their site if you want to listen.)

Good luck with your decision...
1 fistula, crohn's colitis, limited to large intestine
Compounded budesonide 3mg/daily, Cimzia, MTX . Dx Osteoporosis 10/08 started Forteo 1/27/09


Rider Fan
Veteran Member


Date Joined May 2008
Total Posts : 1445
   Posted 6/4/2010 6:42 PM (GMT -7)   
There was another guy on here who went into remission on Tysabri. He was doing so well the company asked him to speak to a group of people about it.
33 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. Proferrin iron pills.

Reduced gluten and dairy.


Go Saskatchewan Roughriders!


Bane
Veteran Member


Date Joined May 2007
Total Posts : 589
   Posted 6/4/2010 10:53 PM (GMT -7)   
I'm about to try Vedolizumab, which is similar to Natalizumab. No sign of PML in any of the hundreds of other trial patients.

I'm looking forward to it, as nothing else has worked for very long.
Diagnosed with Crohn's late December 2004. Narrowly avoiding a full-blown flare on Azathioprine (50mg daily).

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