Humira - Does it Work and If So, How Long?

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DeathStalker
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Date Joined Jun 2010
Total Posts : 4
   Posted 6/26/2010 9:58 AM (GMT -7)   
I took my first four doses of Humira this past Thursday. My doctor said that it has been very effective in many of his patients and from what I've read, it has less side-effects than Remicade.

Anyway, I was wondering if it has worked for many people here and if so, how long did it take to kick in? Also, I am currently on the following medications: 6MP, Apriso (Asacol), topical cortizone, and two probiotics (Align & Saccharomyces boulardii). Any information on Humira would be greatly appreciated. Thanks, CC

Aimee =)
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Date Joined Jun 2004
Total Posts : 1020
   Posted 6/26/2010 11:45 AM (GMT -7)   
Worked very well for me; within 2 weeks of the initial dose I saw a huge change in my health. I was on it 2 years before it wore off - and it was a fantastic 2 years. Competely symptom free! Hope it does the same for you.

DeathStalker
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Date Joined Jun 2010
Total Posts : 4
   Posted 6/26/2010 3:37 PM (GMT -7)   
That's good news Aimee. I was on 6MP for 6 six years - it had put me in complete remission before it wore off this past December. That's why I'm taking the next step now with Humira. Out of curiosity, when it did wear off, what did you do? From what I know, these TNF blockers are the last treatment option once everything else has failed. No way do I want to go the surgery route unless I have no other options.

Also, how often were you using Humira, once a week or every other week? I've heard some people say that had to start using it weekly because it was losing it's effectiveness. Thanks again for your reply,

CC

cupcakespinkgal
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Date Joined Jun 2010
Total Posts : 1277
   Posted 6/26/2010 3:51 PM (GMT -7)   
Humira did not work for me. My doctor kept saying give it more time and I ended up having 2 flares while on it trying to give it time. I also had a lot of side effects I didn't have with Remicade.

What is interesting, I did very well on Remicade for years, no side effects and had complete remission for 4 or 5 years. But my friend had no luck with Remicade and is doing great on Humira. She has been on Humira 2 years now and has no problems. Not sure if it is a coincidence or not!

Good luck, I know for a lot of patients it has really helped and it has helped my friend a lot.
Diagnosed with Crohn's in 1998, father has UC we were diagnosed at the same age.

Currently on 15 mg Prednisone, 4g Sulfasalzine, VSL#3, B complex, Calcium, Magnesium, D3 and Passion Flower. Previously on Remicade, just stopped Humira after 9 months, wasn't working.

No surgeries so far.


DeathStalker
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Date Joined Jun 2010
Total Posts : 4
   Posted 6/26/2010 9:18 PM (GMT -7)   
From what I've read, it does sound like Remicade works for some while Humira works for others. I do think that is strange. Today was a very good day but yesterday, I had a flare up in the afternoon. No real rhyme or reason to it. I just hope the Humira works. Too early to tell at this point but I'm keeping my fingers crossed.

Wolfie40
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Date Joined Dec 2008
Total Posts : 947
   Posted 6/27/2010 5:54 AM (GMT -7)   
Been on it 6 months now, let's hope it continues to work.
Diagnosed with Crohns in 2001
First and hopefully last Ileocecectomy 2/18/2009

Medications:Humira,  Asacol, FolicAcid,  Multivitamin, 1000mg Calcium, Vitamin D, Probiotics, Pepcid Complete, Questran,  Monthly B-12 injections.

Living a Great life with my Wife and my two Chocolate Labs
Hunter & Hailey.
I love them dearly.


Carol
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Date Joined Mar 2003
Total Posts : 21
   Posted 6/27/2010 9:41 AM (GMT -7)   
I've been on Humira for 2-1/2 years and have had no flares or side effects. Before taking Humira I had 3 surgeries and many hospitalizations for flares.

DeathStalker
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Date Joined Jun 2010
Total Posts : 4
   Posted 6/27/2010 1:42 PM (GMT -7)   
Are you guys also taking an immunomodulator drug as well with the Humira? I'm on 6MP and I was hoping to stop it once I started the Humira but my doctor wants me to continue taking it because he says that 6mp combined with Humira, works better.

tulipg17
Regular Member


Date Joined Jun 2010
Total Posts : 113
   Posted 6/27/2010 6:59 PM (GMT -7)   
My Dr said it takes 3 months to kick in fully, and I've just hit the 3 month mark. It's definitely helped with my joint pain and at first I thought it was working for Crohn's disease in general but I landed in the hospital a month ago despite being on it, and I have felt generally ill ever since then. I don't think it's sufficient thus far, but I know I need to give it more time. I have had some side effects though.

JAB
Regular Member


Date Joined Nov 2003
Total Posts : 351
   Posted 6/28/2010 8:13 AM (GMT -7)   
I'm still on Humira and just recently bumped it up to once a week due to it's ineffectiveness. When i first started it back in Sept/Oct. it took about a month to kick in. The next few months were bliss. I mean it....they were beautiful. I was my old self. No gut problems, my diet was what a normal person eats, my true personality came back.
 
Then a couple months ago I started having problems again. Went and had a CT Enterography and determined that I had a number of fistulas and other wonderful things going on. So now I'm back on the doctor's vist circuit trying to find an answer. Surgery or remicade. I have a second opinion coming up. I'm hoping we try the Remicade before we go down the other route.
 
JAB

ZenaWP
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Date Joined Aug 2007
Total Posts : 884
   Posted 6/28/2010 12:58 PM (GMT -7)   
Humira kept my Crohn's in remission for the year I was on it, but I continued to have bad arthritis flares, so we ended up switching to Cimzia.  After a year on that, I have just asked to and have switched back to Humira.  Neither take care of my arthritis enough, but I had a lot less stomach pain on Humira.  It seemed to me to take a month or two to start working and it seemed to not work as well after about a year (thus the first switch).  Many people take it weekly, but according to my GI and rheumy both, they can't get it approved more than bi-weekly (I really don't understand this).  I will be asking my GI about this for the third time when I see him in August.  I hope it works for you!!

Crohn's Disease, Acid Reflux/Gastritis, Hashimoto's Thyroiditis, Endometriosis, Arthritis, Depression/Anxiety.  Too many meds to list them all.  =) 


staci100
Regular Member


Date Joined Mar 2006
Total Posts : 111
   Posted 6/28/2010 1:58 PM (GMT -7)   
It took exactly 6 weeks to kick in for me and was great up until a month ago. I got Shingles and they somewhat took over my body.....ended up in the hospital due to my immune system being so suppressed by the Humira nd Immuran. Don't mean to scare anyone but it scared me. They took me off of those two drugs and left me on Asacol and CD has kicked back in full force. The Humira worked great during the time I was on it.
34>
Diagnosed with CD 1993



Currently taking Asacol, B-12, Folic Acid, Probiotic


Aimee =)
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Date Joined Jun 2004
Total Posts : 1020
   Posted 6/28/2010 9:54 PM (GMT -7)   
Deathstalker -

We bumped to weekly injections once we saw signs it was wearing off. That helped for awhile. I moved to Cimzia after the Humira failed but I had too much damage. We did surgery and now I'm just on 6MP (though my disease is active again, just 35 days after surgery or so). GI says Cimzia is still an option again since I responded well to it but we're waiting to see if the 6MP will kick this stuff into remission. So, you could always try Cimzia (I did Remicade, than Humira, than Cimzia).

I started with every other week then moved to weekly.

Hope that helps!

kmfdm
Regular Member


Date Joined Jun 2008
Total Posts : 78
   Posted 6/29/2010 1:28 AM (GMT -7)   
I have been on Humira for 2 years now but do not take any other meds except for vitamins.  I suggest you give it time in order to feel better and perhaps stop the other meds that never seemed to work before. 
 

kmfdm
Regular Member


Date Joined Jun 2008
Total Posts : 78
   Posted 6/29/2010 1:37 AM (GMT -7)   
I also have shingles and of course arthitis. I have never heard of Cimzia. Humira seems to be slowly stopping it's effectness bi-weekly. Perhaps I should try weekly but I don't think it will be covered. If there are any other recommendations please let me know. I recently was hospitalized for what they thought was C-Dif which is a common bacteria in hospitals. I think the Humira is starting to become immune to my system.

Rider Fan
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Date Joined May 2008
Total Posts : 1445
   Posted 6/29/2010 8:19 AM (GMT -7)   
Aimee =) said...
Deathstalker -

We bumped to weekly injections once we saw signs it was wearing off. That helped for awhile. I moved to Cimzia after the Humira failed but I had too much damage. We did surgery and now I'm just on 6MP (though my disease is active again, just 35 days after surgery or so). GI says Cimzia is still an option again since I responded well to it but we're waiting to see if the 6MP will kick this stuff into remission. So, you could always try Cimzia (I did Remicade, than Humira, than Cimzia).

I started with every other week then moved to weekly.

Hope that helps!


Oh no! I'm sorry it came back so quickly. Hang in there, I'm sure the 6MP will kick in shortly.
33 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. Proferrin iron pills.

Reduced gluten and dairy.


Go Saskatchewan Roughriders!


Aimee =)
Veteran Member


Date Joined Jun 2004
Total Posts : 1020
   Posted 6/29/2010 9:38 AM (GMT -7)   
kmfdm said...
I also have shingles and of course arthitis. I have never heard of Cimzia. Humira seems to be slowly stopping it's effectness bi-weekly. Perhaps I should try weekly but I don't think it will be covered. If there are any other recommendations please let me know. I recently was hospitalized for what they thought was C-Dif which is a common bacteria in hospitals. I think the Humira is starting to become immune to my system.
 
Sorry - I can't seem to respond to a quote - won't let me out of the box when I try to reply. Weird. Anyways, talk to your GI about bumping dosage. I had a PITA insurance at the time and had no issues getting the added doses approved. My GI just submitted the reasoning (which at the time was bumped drug or surgery) and they approved it without an issue. It's worth a try!
 
There are lots of threads about Cimzia if you search; it's similar to Humira in that you inject it at home and is a TNF blocker like Remicade and Humira. Also used for RA.

JonJon
Regular Member


Date Joined Jun 2004
Total Posts : 59
   Posted 7/6/2010 1:37 PM (GMT -7)   
I have been on Humira for 5+ years now. I take it weekly. I was a drug study patient for Abbott before the FDA approved it for CD.

It does burn, but it has worked very well for me. I have only had to have 1 surgery since and that was strictures before I started the Humira.

I also take Imuran too. There are a few more new drugs out there now, but at the time I stated Humira I was up against the wall. I had tried everything to no avail.

The best thing is to have trust in your doctors. And don't leave anything out. Thats what your paying them for. I truley believe my doctor has my best interest at heart and he is a very caring man. My surgeon is awesome too!
 
 
                            
 
 
                          Happiness is having extra toilet paper!
                     
                                    

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