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grayeyedblonde
Regular Member


Date Joined Jul 2008
Total Posts : 383
   Posted 6/28/2010 11:57 AM (GMT -7)   
I am starting my 3rd month of Humira, but I'm not sure if its working.
 
After my open surgery a year ago, I continued to have D and I developed another fistula, but was not having any pain. My D was constant, averaging between 8-12/day. I was taking up to 3 immodium/day to try and keep it in check and wld still have 5-6 BM's per day, usually of a pudding type consistency. If I didn't take immodium, it was mostly water. I was also gassy, bloated and having the major gurgling going on.
 
After the first 4 loading doses, I was able to go off the immodium, stools dropped to about 5 per day and other than being tired, I felt good. 2 weeks later I took the additional 2 doses and was fine for the first week, then started having D again on a regular basis. This past month (the 2nd month of being on it) I take 1 dose every other week. I get no relief from the D at all, and have had to go back on the immodium taking it 1-2 times a day again. I am again gassy and bloated, and every time I eat, I can feel the food gurgling through.  I am also exhausted, especially the first week after taking the Humira. Not having any pain, I am not losing weight ( in fact, I feel like I'm gaining) and I'm not nauseaus, just will have a general 'not feeling well' feeling a couple times a week.
 
I know that Humira can take 3 months or more to kick in, but how come I felt good the first month and it has been going downhill since? Do you think it may have stopped working for me? I haven't called the Dr. yet cause I know he will just tell me to give it more time, but I guess I'm questioning if I'm even flaring. My Dr. was at first concerned after my surgery because I was continuing to have D, but when I explained to him that over the past 15 years that I rarely DON'T have D, just not as many episodes, he seemed to relax. I'm getting frustrated and I know I'm one of those people who will just "deal" with it, so I guess I'm just asking if this may be normal, or should I go back and tell him that it's just not working out. Asacol and Apriso both made my D 10x worse, so I don't seem to tolerate the 5-ASA's.
 
Opinions? Suggestions? Comments?
 
Thanks.
Dx'd w/ Crohn's in 1979 at age 13. Bad flare 2008 but no health insurance so I dealt with it. Colonoscopy in July 2009 caused a perforated colon, emergency bowel resection. 2 fistula's, perianal and perivaginal.

Humira, probiotic, a multivitamin, calcium, magnesium, zinc, and fish oil. I also take Tramadol 50 mg and Klonopin (for anxiety) as needed.

Life may not be the party we hoped for, but while we are here we might as well dance!


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 6/28/2010 12:16 PM (GMT -7)   
It could be possible that you have a bacterial overgrowth going on. Since I have had my resections I tend to get them more frequently now. They are easily treated with a 10 day course of Cipro. Might be something to discuss with your doctor. Hugs~
Gail*Nanners* Co-Moderator for Crohns Disease 
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Wolfie40
Veteran Member


Date Joined Dec 2008
Total Posts : 947
   Posted 6/28/2010 4:14 PM (GMT -7)   
I take Questran everyday cuz of my surgery removing the Ileum. Thats where your body absorbs bile or something like that and the Questran binds it so you don't have "D". I never really had "D" prior to surgery, but once they removed it I seemed to have it along with burning and itching. Doc said to go on Questran and now everything is fine. If I miss a dose or two I do get some "D".
The Humira has been working for me and you need to give it more time. I have gained weight since being on it also.
I hope you feel better soon.
Diagnosed with Crohns in 2001
First and hopefully last Ileocecectomy 2/18/2009

Medications:Humira,  Asacol, FolicAcid,  Multivitamin, 1000mg Calcium, Vitamin D, Probiotics, Pepcid Complete, Questran,  Monthly B-12 injections.

Living a Great life with my Wife and my two Chocolate Labs
Hunter & Hailey.
I love them dearly.


CrohnieToo
Veteran Member


Date Joined May 2003
Total Posts : 9448
   Posted 6/28/2010 4:48 PM (GMT -7)   
I second Nanner's suggestion of bacterial overgrowth in the small intestine. I've gone thru that before. More times than I care to count. For a while, maybe a year, I had to resort to alternating two antibiotics the first 10 days of every month (as well as a good probiotic).

Since I also have COPD we were somewhat concerned about using the big guns such as Cipro and then running into a COPD exacerbation that was resistant to Cipro or one of the other big guns so we opted to try a couple of the older antibiotics to see if we could get a favorable response. Tetracycline and Amoxicillin worked for me.

I'm currently encountering my classic symptoms of bacterial overgrowth after not having any problem w/it for several years and most likely will be starting Tet or Moxi by the end of this week or beginning of the next.
My computer says I need to upgrade my brain to be compatible with its new software.


grayeyedblonde
Regular Member


Date Joined Jul 2008
Total Posts : 383
   Posted 6/28/2010 8:29 PM (GMT -7)   
Thank you all for your replies. I just googled bacterial overgrowth and it fits my symptoms to a T. My Dr. said if I felt like I was catching something to let him know immediately and he would call me in some antibiotics since I don't have a primary Dr. I will try calling him tomorrow and see what he says.

Thanks again!
Dx'd w/ Crohn's in 1979 at age 13. Bad flare 2008 but no health insurance so I dealt with it. Colonoscopy in July 2009 caused a perforated colon, emergency bowel resection. 2 fistula's, perianal and perivaginal.

Humira, probiotic, a multivitamin, calcium, magnesium, zinc, and fish oil. I also take Tramadol 50 mg and Klonopin (for anxiety) as needed.

Life may not be the party we hoped for, but while we are here we might as well dance!

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