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Not2Spunky
Regular Member


Date Joined Feb 2008
Total Posts : 165
   Posted 7/1/2010 4:39 PM (GMT -7)   
Are these two the same meds? I had read that Imuran turns into 6MP in the body is this so? I work for a Dr in a Family Practie Dept and my GP (not the Dr I work for) told me that if I was started on 6MP I would not be able to room patients with a high fever or very sick. That would be the majority of our practice. Do I need to worry about that?
Thank You, KayC
 RIP my beloved Chihuahua: Roxy
DX with CD of the TI in 2004 by colonoscpy biopsy, with partical obstructions x 3. Anemic, constant elevated ESR & WBC. Constant abd. pain and fatique.    
Meds: Vit B-12 shots monthly, zinc, multi vit, Vit E, Pentasa.    


NiceCupOfTea
Veteran Member


Date Joined Jan 2010
Total Posts : 8561
   Posted 7/1/2010 5:29 PM (GMT -7)   
They end up the same; Imuran gets broken down into 6MP in the body. But there's something about that extra step which ensures the two drugs work differently - I don't know how, it was a long time ago that I read it. But it's possible for one drug to work where one doesn't, or for one to cause a bad reaction where the other one doesn't. So effectively they are two different, if similar, meds.

I'm rather dubious about what your GP said. A minority of people cannot tolerate 6MP/Imuran and have to come off it, because it lowers their white blood cells dangerously - that's what the regular blood tests in the beginning monitor. But once it's established that you can tolerate 6MP I'm fairly certain there is no increased risk of infection at the doses Crohn's patients typically take it at. (Lower than cancer and transplant patients.)

I'd try to get a second opinion on that one.

tooth
Regular Member


Date Joined Jun 2010
Total Posts : 337
   Posted 7/1/2010 5:53 PM (GMT -7)   
Honestly, I don't think you have to worry about getting sick from patients with fevers and colds. Dosages for Crohn's patients are low and usually keep WBC within normal levels. When my WBC dropped once while I was on Imuran, my doctor decreased the dosage until my WBC went back up.

I've been using Imuran for 8 years now and can only remember getting the flu once and maybe a couple of colds. And I have live in dorms and spent 4 years working on patients in my dental school without much trouble at all. Though you might want to talk your boss and see what his take is...I think your GP might be a little too overzealous about what he's telling you...
Diagnosed 2002 at 18. Remission for about 7 years. Getting back into the swing of things at 26.

75mg Imuran, 750mg Balsalazide 3x day, Tapering Pred.

Maybe flaring...maybe not?


notsosicklygirl
Forum Moderator


Date Joined Dec 2008
Total Posts : 14165
   Posted 7/1/2010 6:13 PM (GMT -7)   
My doctor recommended 6mp over Imuran because she said it is less likely to cause side effects. I didn't ask for any more details. Not sure why this is the case or if I even understood her correctly.
March 07: DIagnosed with Mild Proctitis - Canasa as needed.
August 08 - December 08: FLARE & Anemic - Started Asacol!!
January 09 - December 09: REMISSION!! Asacol (9) + Canasa 1g AM/PM
December 09 - January 10: FLARE!! Asacol + Prednisone + Canasa
February 10 - April 10: Colazal + Prednisone + Canasa
May 10 - June 10: Lialda + Cort Enema + Prednisone
Current: Mild / Moderate Active Pancolitis: Prednisone, 6mp, klonopin FEELING OKAY!!


Not2Spunky
Regular Member


Date Joined Feb 2008
Total Posts : 165
   Posted 7/1/2010 9:19 PM (GMT -7)   
Good replys, Thank You all.
 RIP my beloved Chihuahua: Roxy
DX with CD of the TI in 2004 by colonoscpy biopsy, with partical obstructions x 3. Anemic, constant elevated ESR & WBC. Constant abd. pain and fatique.    
Meds: Vit B-12 shots monthly, zinc, multi vit, Vit E, Pentasa.    


Grandpato2
Veteran Member


Date Joined Dec 2009
Total Posts : 681
   Posted 7/2/2010 1:04 AM (GMT -7)   
Please consider that a cold or flu is one thing but consider other serious infectuous diseases you might be exposed to. You may need to ask your office Dr. what kind of patients you might be serving?
Male, 55 years old with Crohn's since 15 years old, diagnosed at age 46. Terminal ileum resected 2002. 5 months of remission. Crohn's has now been active since May, 2003. Had a gall bladder removed Nov. of 2009. Currently on Remicade every 8 weeks, Nexium, Iron, B-12 injection every 4 weeks, Morphine Sulfate as needed for pain. Cymbalta for long term pain control. In the past, 5-asa Salofalk, Asacol, Entocort,  Imuran and Prednisone.


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 7/2/2010 7:48 AM (GMT -7)   
I had problems with Imuran, it made me TOO nauseous. But I switched to 6mp no problem and had way less side effects. Hope that helps a little.
Gail*Nanners* Co-Moderator for Crohns Disease 
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*
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